PMID- 36290673
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221030
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 11
IP  - 10
DP  - 2022 Sep 29
TI  - Time-Course Changes in Oxidative Stress and Inflammation in the Retinas of rds 
      Mice: A Retinitis Pigmentosa Model.
LID - 10.3390/antiox11101950 [doi]
LID - 1950
AB  - (1) Background: Retinitis pigmentosa (RP) is characterized by progressive 
      photoreceptor death. A Prph2Rd2 or an rds mouse is an RP model that closely 
      reflects human RP. The objective of this study was to investigate the 
      relationship of rod and cone death with oxidative stress and inflammation in rds 
      mice. (2) Methods: The retinas of control and rds mice on postnatal days (PN) 11, 
      17, 21, 28, 35, and 42 were used. Oxidative damage to macromolecules, glutathione 
      (GSH and GSSG), GSH synthesis enzymes, glial fibrillar acidic protein (GFAP), 
      ionized calcium-binding adapter molecule 1 (Iba1), and cluster of differentiation 
      68 (CD68) was studied. (3) Results: The time sequence of oxidative stress and 
      inflammation changes in rds mice occurs as follows: (i) At PN11, there is a small 
      increase in photoreceptor death and in the microglial cells; (ii) at PN17, damage 
      to the macromolecules is observed; (iii) at PN21, the maximum photoreceptor death 
      rate is detected and there is an increase in GSH-GSSG and GFAP; (iv) at PN21, the 
      microglial cells are activated; and(v) at PN28, there is a decrease in GSH 
      synthesis enzymes. (4) Conclusions: These findings contribute to the 
      understanding of RP physiopathology and help us to understand whether oxidative 
      stress and inflammation are therapeutic targets. These findings contribute to our 
      understanding that, in RP, oxidative stress and inflammation evolution and their 
      relationship are time-dependent. In this sense, it is important to highlight that 
      both processes are potential therapeutic targets in this disease.
FAU - Canto, Antolin
AU  - Canto A
AUID- ORCID: 0000-0002-4269-3517
AD  - Department of Biomedical Sciences, Faculty of Health Sciences, Institute of 
      Biomedical Sciences, Cardenal Herrera-CEU University, CEU Universities, 46115 
      Valencia, Spain.
FAU - Martinez-Gonzalez, Javier
AU  - Martinez-Gonzalez J
AUID- ORCID: 0000-0003-2143-8338
AD  - Department of Biomedical Sciences, Faculty of Health Sciences, Institute of 
      Biomedical Sciences, Cardenal Herrera-CEU University, CEU Universities, 46115 
      Valencia, Spain.
FAU - Almansa, Inmaculada
AU  - Almansa I
AD  - Department of Biomedical Sciences, Faculty of Health Sciences, Institute of 
      Biomedical Sciences, Cardenal Herrera-CEU University, CEU Universities, 46115 
      Valencia, Spain.
FAU - Lopez-Pedrajas, Rosa
AU  - Lopez-Pedrajas R
AD  - Department of Biomedical Sciences, Faculty of Health Sciences, Institute of 
      Biomedical Sciences, Cardenal Herrera-CEU University, CEU Universities, 46115 
      Valencia, Spain.
FAU - Hernandez-Rabaza, Vicente
AU  - Hernandez-Rabaza V
AD  - Department of Biomedical Sciences, Faculty of Health Sciences, Institute of 
      Biomedical Sciences, Cardenal Herrera-CEU University, CEU Universities, 46115 
      Valencia, Spain.
FAU - Olivar, Teresa
AU  - Olivar T
AD  - Department of Biomedical Sciences, Faculty of Health Sciences, Institute of 
      Biomedical Sciences, Cardenal Herrera-CEU University, CEU Universities, 46115 
      Valencia, Spain.
FAU - Miranda, Maria
AU  - Miranda M
AD  - Department of Biomedical Sciences, Faculty of Health Sciences, Institute of 
      Biomedical Sciences, Cardenal Herrera-CEU University, CEU Universities, 46115 
      Valencia, Spain.
LA  - eng
GR  - Consolidacion de Indicadores CEU-UCH 2021-2022 INDI21/39 y Proyectos 
      Precompetitivos CEU 2020-2021 FUSP-BS-PPC19-19F1741D and the grants ACIF/199/2019 
      and FPU 20/06277/CEU Cardinal Herrera University/
PT  - Journal Article
DEP - 20220929
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC9598580
OTO - NOTNLM
OT  - 8-oxoguanine
OT  - glutathione
OT  - hydroxynonenal
OT  - inflammation
OT  - macroglia
OT  - microglia
OT  - oxidative stress
COIS- The authors declare no conflicts of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of the data; 
      in the writing of the manuscript; or in the decision to publish the results.
EDAT- 2022/10/28 06:00
MHDA- 2022/10/28 06:01
PMCR- 2022/09/29
CRDT- 2022/10/27 01:07
PHST- 2022/08/17 00:00 [received]
PHST- 2022/09/23 00:00 [revised]
PHST- 2022/09/26 00:00 [accepted]
PHST- 2022/10/27 01:07 [entrez]
PHST- 2022/10/28 06:00 [pubmed]
PHST- 2022/10/28 06:01 [medline]
PHST- 2022/09/29 00:00 [pmc-release]
AID - antiox11101950 [pii]
AID - antioxidants-11-01950 [pii]
AID - 10.3390/antiox11101950 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2022 Sep 29;11(10):1950. doi: 10.3390/antiox11101950.