PMID- 36290718
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221030
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 11
IP  - 10
DP  - 2022 Oct 8
TI  - The Complex Interplay between Mitochondria, ROS and Entire Cellular Metabolism.
LID - 10.3390/antiox11101995 [doi]
LID - 1995
AB  - Besides their main function for energy production in form of ATP in processes of 
      oxidative phosphorylation (OxPhos), mitochondria perform many other important 
      cellular functions and participate in various physiological processes that are 
      congregated. For example, mitochondria are considered to be one of the main 
      sources of reactive oxygen species (ROS) and therefore they actively participate 
      in the regulation of cellular redox and ROS signaling. These organelles also play 
      a crucial role in Ca(2+) signaling and homeostasis. The mitochondrial OxPhos and 
      their cellular functions are strongly cell/tissue specific and can be 
      heterogeneous even within the same cell, due to the existence of mitochondrial 
      subpopulations with distinct functional and structural properties. However, the 
      interplay between different functions of mitochondria is not fully understood. 
      The mitochondrial functions may change as a response to the changes in the 
      cellular metabolism (signaling in). On the other hand, several factors and 
      feedback signals from mitochondria may influence the entire cell physiology 
      (signaling out). Numerous interactions between mitochondria and the rest of cell, 
      various cytoskeletal proteins, endoplasmic reticulum (ER) and other cellular 
      elements have been demonstrated, and these interactions could actively 
      participate in the regulation of mitochondrial and cellular metabolism. This 
      review highlights the important role of the interplay between mitochondrial and 
      entire cell physiology, including signaling from and to mitochondria.
FAU - Kuznetsov, Andrey V
AU  - Kuznetsov AV
AD  - Department of Pediatrics I, Medical University of Innsbruck, A-6020 Innsbruck, 
      Austria.
FAU - Margreiter, Raimund
AU  - Margreiter R
AD  - Department of Visceral, Transplant and Thoracic Surgery, Medical University of 
      Innsbruck, A-6020 Innsbruck, Austria.
FAU - Ausserlechner, Michael J
AU  - Ausserlechner MJ
AUID- ORCID: 0000-0002-1015-2302
AD  - Department of Pediatrics I, Medical University of Innsbruck, A-6020 Innsbruck, 
      Austria.
FAU - Hagenbuchner, Judith
AU  - Hagenbuchner J
AUID- ORCID: 0000-0003-1396-3407
AD  - Department of Pediatrics II, Medical University of Innsbruck, A-6020 Innsbruck, 
      Austria.
LA  - eng
GR  - I3089-B28/FWF Austrian Science Fund/
PT  - Journal Article
PT  - Review
DEP - 20221008
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC9598390
OTO - NOTNLM
OT  - ROS
OT  - calcium
OT  - cellular metabolism
OT  - mitochondria
OT  - mitochondrial function/morphology
OT  - mitochondrial interactions
OT  - redox state
OT  - signaling
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/10/28 06:00
MHDA- 2022/10/28 06:01
PMCR- 2022/10/08
CRDT- 2022/10/27 01:07
PHST- 2022/08/11 00:00 [received]
PHST- 2022/09/26 00:00 [revised]
PHST- 2022/09/27 00:00 [accepted]
PHST- 2022/10/27 01:07 [entrez]
PHST- 2022/10/28 06:00 [pubmed]
PHST- 2022/10/28 06:01 [medline]
PHST- 2022/10/08 00:00 [pmc-release]
AID - antiox11101995 [pii]
AID - antioxidants-11-01995 [pii]
AID - 10.3390/antiox11101995 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2022 Oct 8;11(10):1995. doi: 10.3390/antiox11101995.