PMID- 3629126
OWN - NLM
STAT- MEDLINE
DCOM- 19870928
LR  - 20041117
IS  - 0035-6344 (Print)
IS  - 0035-6344 (Linking)
VI  - 57
IP  - 1
DP  - 1987 Jan-Feb
TI  - Experimental allergic encephalomyelitis, a model of demyelination in central 
      nervous system (CNS).
PG  - 27-32
AB  - Different forms of experimental allergic encephalomyelitis were obtained in 31 
      guinea pigs. Four groups of animals were studied: 7 adult Hartley guinea pigs 
      (Group 1), 12 adult Hartley guinea pigs (Group 2), 6 juvenile strain 2 guinea 
      pigs (Group 3), 6 juvenile strain 13 guinea pigs (Group 4). The increment of the 
      antigenic load induced different disease courses in the animals. The different 
      disease courses were attributed to differential inactivation of the cell-mediated 
      response to the injected antigens. The intraneural injection of serum withdrawn 
      from guinea pigs affected by EAE induced demyelination in the optic nerve fibers 
      of healthy rats. Areas of demyelination with naked axons were evident 30 days 
      following the injection when Visual Evoked Potential (VEP) delays were of as much 
      as 27 msec. Our experiments demonstrated the activity of EAE sera (probably 
      antiGal-Cer antibodies) on the myelin sheats of nervous fibers.
FAU - Gambi, D
AU  - Gambi D
FAU - Onofrj, M
AU  - Onofrj M
FAU - Di Trapani, G
AU  - Di Trapani G
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Riv Neurol
JT  - Rivista di neurologia
JID - 0413740
RN  - 0 (Antibodies, Neoplasm)
SB  - IM
MH  - Animals
MH  - Antibodies, Neoplasm/*immunology
MH  - Antigen-Antibody Reactions
MH  - Encephalomyelitis, Autoimmune, 
      Experimental/complications/*immunology/pathology/physiopathology
MH  - Evoked Potentials, Visual
MH  - Guinea Pigs
MH  - Immunity, Cellular
MH  - Myelin Sheath/*immunology
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
PST - ppublish
SO  - Riv Neurol. 1987 Jan-Feb;57(1):27-32.