PMID- 36291329 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230308 IS - 2076-3425 (Print) IS - 2076-3425 (Electronic) IS - 2076-3425 (Linking) VI - 12 IP - 10 DP - 2022 Oct 16 TI - Adherence and Reactogenicity to Vaccines against SARS-COV-2 in 285 Patients with Neuropathy: A Multicentric Study. LID - 10.3390/brainsci12101396 [doi] LID - 1396 AB - Background: The safety of the new vaccines against SARS-CoV-2 have already been shown, although data on patients with polyneuropathy are still lacking. The aim of this study is to evaluate the adherence to SARS-CoV-2 vaccination, as well as the reactogenicity to those vaccines in patients affected by neuropathy. Methods: A multicentric and web-based cross-sectional survey was conducted among patients affected by neuropathy from part of South Italy. Results: Out of 285 responders, n = 268 were included in the final analysis and n = 258 of them (96.3%) were fully vaccinated. Adherence to vaccination was higher in patients with hereditary neuropathies compared to others, while it was lower in patients with anti-MAG neuropathy (all p < 0.05). The overall prevalence of adverse events (AEs) was 61.2% and its occurrence was not associated with neuropathy type. Being female and of younger age were factors associated with higher risk of AEs, while having an inflammatory neuropathy and steroids assumption were associated with a lower risk (all p < 0.05). Younger age, having had an AE, and COVID-19 before vaccination were factors associated with symptoms worsening after vaccination (all p < 0.05). (4) Conclusions: Patients with neuropathy showed a high level of adherence to COVID-19 vaccination. Safety of vaccines in patients with neuropathies was comparable to the general population and it was more favorable in those with inflammatory neuropathy. FAU - Iacono, Salvatore AU - Iacono S AUID- ORCID: 0000-0003-0035-5859 AD - Neurology Unit, Department of Biomedicine, Neuroscience, and Advanced Diagnostics (BiND), University of Palermo, 90129 Palermo, Italy. FAU - Di Stefano, Vincenzo AU - Di Stefano V AUID- ORCID: 0000-0001-9805-1655 AD - Neurology Unit, Department of Biomedicine, Neuroscience, and Advanced Diagnostics (BiND), University of Palermo, 90129 Palermo, Italy. FAU - Alonge, Paolo AU - Alonge P AD - Neurology Unit, Department of Biomedicine, Neuroscience, and Advanced Diagnostics (BiND), University of Palermo, 90129 Palermo, Italy. FAU - Vinciguerra, Claudia AU - Vinciguerra C AD - Neurology Unit, University Hospital "San Giovanni di Dio e Ruggi D'Aragona", 84131 Salerno, Italy. FAU - Milella, Giammarco AU - Milella G AUID- ORCID: 0000-0002-7612-382X AD - Neurology Unit, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro", 70124 Bari, Italy. FAU - Caputo, Francesca AU - Caputo F AUID- ORCID: 0000-0002-6734-0523 AD - Neurology Unit, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro", 70124 Bari, Italy. FAU - Lasorella, Piergiorgio AU - Lasorella P AD - Neurology Unit, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro", 70124 Bari, Italy. FAU - Neto, Gabriele AU - Neto G AD - Neurology Unit, Department of Biomedicine, Neuroscience, and Advanced Diagnostics (BiND), University of Palermo, 90129 Palermo, Italy. FAU - Pignolo, Antonia AU - Pignolo A AUID- ORCID: 0000-0002-8883-5701 AD - Neurology Unit, Department of Biomedicine, Neuroscience, and Advanced Diagnostics (BiND), University of Palermo, 90129 Palermo, Italy. FAU - Torrente, Angelo AU - Torrente A AUID- ORCID: 0000-0002-0585-8351 AD - Neurology Unit, Department of Biomedicine, Neuroscience, and Advanced Diagnostics (BiND), University of Palermo, 90129 Palermo, Italy. FAU - Lupica, Antonino AU - Lupica A AUID- ORCID: 0000-0003-1499-9460 AD - Neurology Unit, Department of Biomedicine, Neuroscience, and Advanced Diagnostics (BiND), University of Palermo, 90129 Palermo, Italy. FAU - Ajdinaj, Paola AU - Ajdinaj P AUID- ORCID: 0000-0002-8173-1723 AD - Department of Neurology, SS Annunziata Hospital, 66100 Chieti, Italy. FAU - Firenze, Alberto AU - Firenze A AD - Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Speialities, University of Palermo, 90127 Palermo, Italy. FAU - Tozza, Stefano AU - Tozza S AUID- ORCID: 0000-0002-9672-4577 AD - Department of Neuroscience, Reproductive and Odontostomatology Science, University of Naples Federico II, 80131 Napoli, Italy. FAU - Manganelli, Fiore AU - Manganelli F AD - Department of Neuroscience, Reproductive and Odontostomatology Science, University of Naples Federico II, 80131 Napoli, Italy. FAU - Di Muzio, Antonio AU - Di Muzio A AD - Department of Neurology, SS Annunziata Hospital, 66100 Chieti, Italy. FAU - Piscosquito, Giuseppe AU - Piscosquito G AD - Neurology Unit, University Hospital "San Giovanni di Dio e Ruggi D'Aragona", 84131 Salerno, Italy. FAU - Brighina, Filippo AU - Brighina F AD - Neurology Unit, Department of Biomedicine, Neuroscience, and Advanced Diagnostics (BiND), University of Palermo, 90129 Palermo, Italy. LA - eng PT - Journal Article DEP - 20221016 PL - Switzerland TA - Brain Sci JT - Brain sciences JID - 101598646 PMC - PMC9599423 OTO - NOTNLM OT - CIDP OT - COVID-19 vaccines OT - SARS-CoV-2 infection OT - autoimmune neuropathy OT - hereditary neuropathy OT - neuropathy OT - reactogenicity OT - vaccine hesitancy OT - vaccine safety COIS- The authors declare no conflict of interest. EDAT- 2022/10/28 06:00 MHDA- 2022/10/28 06:01 PMCR- 2022/10/16 CRDT- 2022/10/27 01:11 PHST- 2022/09/21 00:00 [received] PHST- 2022/10/08 00:00 [revised] PHST- 2022/10/11 00:00 [accepted] PHST- 2022/10/27 01:11 [entrez] PHST- 2022/10/28 06:00 [pubmed] PHST- 2022/10/28 06:01 [medline] PHST- 2022/10/16 00:00 [pmc-release] AID - brainsci12101396 [pii] AID - brainsci-12-01396 [pii] AID - 10.3390/brainsci12101396 [doi] PST - epublish SO - Brain Sci. 2022 Oct 16;12(10):1396. doi: 10.3390/brainsci12101396.