PMID- 36291332
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221030
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 12
IP  - 10
DP  - 2022 Oct 17
TI  - Phase Lag Index of Resting-State EEG for Identification of Mild Cognitive 
      Impairment Patients with Type 2 Diabetes.
LID - 10.3390/brainsci12101399 [doi]
LID - 1399
AB  - Mild cognitive impairment (MCI) is one of the important comorbidities of type 2 
      diabetes mellitus (T2DM). It is critical to find appropriate methods for early 
      diagnosis and objective assessment of mild cognitive impairment patients with 
      type 2 diabetes (T2DM-MCI). Our study aimed to investigate potential early 
      alterations in phase lag index (PLI) and determine whether it can distinguish 
      between T2DM-MCI and normal controls with T2DM (T2DM-NC). EEG was recorded in 30 
      T2DM-MCI patients and 30 T2DM-NC patients. The phase lag index was computed and 
      used in a logistic regression model to discriminate between groups. The 
      correlation between the phase lag index and Montreal Cognitive Assessment (MoCA) 
      score was assessed. The alpha-band phase lag index was significantly decreased in the 
      T2DM-MCI group compared with the T2DM-NC group and showed a moderate degree of 
      classification accuracy. The MoCA score was positively correlated with the alpha-band 
      phase lag index (r = 0.4812, moderate association, p = 0.015). This work shows 
      that the functional connectivity analysis of EEG may offer an effective way to 
      track the cortical dysfunction linked to the cognitive deterioration of T2DM 
      patients, and the alpha-band phase lag index may have a role in guiding the diagnosis 
      of T2DM-MCI.
FAU - Kuang, Yuxing
AU  - Kuang Y
AD  - The Second School of Clinical Medicine, Southern Medical University, Guangzhou 
      510515, China.
AD  - Department of Rehabilitation, Affiliated Baoan Hospital of Shenzhen, Southern 
      Medical University (The People's Hospital of Baoan Shenzhen), Shenzhen 518101, 
      China.
FAU - Wu, Ziyi
AU  - Wu Z
AD  - The Second School of Clinical Medicine, Southern Medical University, Guangzhou 
      510515, China.
AD  - Department of Rehabilitation, Affiliated Baoan Hospital of Shenzhen, Southern 
      Medical University (The People's Hospital of Baoan Shenzhen), Shenzhen 518101, 
      China.
FAU - Xia, Rui
AU  - Xia R
AD  - Department of Rehabilitation, Affiliated Baoan Hospital of Shenzhen, Southern 
      Medical University (The People's Hospital of Baoan Shenzhen), Shenzhen 518101, 
      China.
FAU - Li, Xingjie
AU  - Li X
AD  - Department of Rehabilitation, Affiliated Baoan Hospital of Shenzhen, Southern 
      Medical University (The People's Hospital of Baoan Shenzhen), Shenzhen 518101, 
      China.
FAU - Liu, Jun
AU  - Liu J
AD  - Department of Rehabilitation, Affiliated Baoan Hospital of Shenzhen, Southern 
      Medical University (The People's Hospital of Baoan Shenzhen), Shenzhen 518101, 
      China.
FAU - Dai, Yalan
AU  - Dai Y
AUID- ORCID: 0000-0001-6629-7247
AD  - Department of Rehabilitation, Affiliated Baoan Hospital of Shenzhen, Southern 
      Medical University (The People's Hospital of Baoan Shenzhen), Shenzhen 518101, 
      China.
FAU - Wang, Dan
AU  - Wang D
AD  - Department of Rehabilitation, Affiliated Baoan Hospital of Shenzhen, Southern 
      Medical University (The People's Hospital of Baoan Shenzhen), Shenzhen 518101, 
      China.
FAU - Chen, Shangjie
AU  - Chen S
AD  - The Second School of Clinical Medicine, Southern Medical University, Guangzhou 
      510515, China.
AD  - Department of Rehabilitation, Affiliated Baoan Hospital of Shenzhen, Southern 
      Medical University (The People's Hospital of Baoan Shenzhen), Shenzhen 518101, 
      China.
LA  - eng
GR  - 81973922/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20221017
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC9599801
OTO - NOTNLM
OT  - diabetes
OT  - mild cognitive impairment
OT  - phase lag index
OT  - resting-state EEG
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2022/10/28 06:00
MHDA- 2022/10/28 06:01
PMCR- 2022/10/17
CRDT- 2022/10/27 01:11
PHST- 2022/09/10 00:00 [received]
PHST- 2022/10/02 00:00 [revised]
PHST- 2022/10/07 00:00 [accepted]
PHST- 2022/10/27 01:11 [entrez]
PHST- 2022/10/28 06:00 [pubmed]
PHST- 2022/10/28 06:01 [medline]
PHST- 2022/10/17 00:00 [pmc-release]
AID - brainsci12101399 [pii]
AID - brainsci-12-01399 [pii]
AID - 10.3390/brainsci12101399 [doi]
PST - epublish
SO  - Brain Sci. 2022 Oct 17;12(10):1399. doi: 10.3390/brainsci12101399.