PMID- 36292092
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221030
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 12
IP  - 10
DP  - 2022 Oct 3
TI  - Performance Score (T2D)-A New Perspective in the Assessment of Six-Minute Walking 
      Tests in Pulmonary Rehabilitation.
LID - 10.3390/diagnostics12102402 [doi]
LID - 2402
AB  - Because absolute changes in outcomes are difficult to interpret and the minimal 
      clinically important difference (MCID) is not suitable to address this challenge, 
      a novel method of classifying outcomes by relating changes to baseline values is 
      warranted. We used the "performance score" (T2D), which reflects individual 
      performance, enabling us to consider the functional status at the beginning of 
      rehabilitation without dealing with the problems of mathematical coupling or 
      regression effects, as encountered in ANCOVA. To illustrate the T2D, we 
      retrospectively analyzed changes in the six-minute walking test (6MWT) in COPD 
      patients undergoing outpatient pulmonary rehabilitation and compared the results 
      with absolute differences related to a predetermined MCID. We evaluated a total 
      of 575 COPD patients with a mean age of 61.4 +/- 9.2 years. 6MWT improved 
      significantly, with a mean change of 32.3 +/- 71.2. A total of 105/311 participants 
      who had reached the MCID were still classified as "below average" by the T2D. 
      Conversely, 76/264 patients who had not reached the MCID were classified as 
      "above average". This new performance measure accounts for the patient's current 
      status and for changes over time, potentially representing a simple and 
      user-friendly tool that can be used to quantify a patient's performance and 
      response to rehabilitation.
FAU - Wagner, Barbara
AU  - Wagner B
AUID- ORCID: 0000-0002-1239-6538
AD  - Department of Physical Medicine, Rehabilitation and Occupational Medicine, 
      Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
FAU - Zdravkovic, Andrej
AU  - Zdravkovic A
AD  - Department of Physical Medicine, Rehabilitation and Occupational Medicine, 
      Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
FAU - Pirchl, Michael
AU  - Pirchl M
AD  - Ludwig Boltzmann Institute for Rehabilitation Research, Kurbadstrasse 14, 1100 
      Vienna, Austria.
FAU - Puhan, Milo A
AU  - Puhan MA
AD  - Epidemiology, Biostatistics and Prevention Institute, University of Zurich, 
      Hirschengraben 84, 8001 Zurich, Switzerland.
FAU - Zwick, Ralf Harun
AU  - Zwick RH
AD  - Ludwig Boltzmann Institute for Rehabilitation Research, Kurbadstrasse 14, 1100 
      Vienna, Austria.
AD  - Therme Wien Med, Kurbadstrasse 14, 1100 Vienna, Austria.
FAU - Grote, Vincent
AU  - Grote V
AUID- ORCID: 0000-0002-4421-2449
AD  - Department of Physical Medicine, Rehabilitation and Occupational Medicine, 
      Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
AD  - Ludwig Boltzmann Institute for Rehabilitation Research, Kurbadstrasse 14, 1100 
      Vienna, Austria.
FAU - Crevenna, Richard
AU  - Crevenna R
AD  - Department of Physical Medicine, Rehabilitation and Occupational Medicine, 
      Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
FAU - Fischer, Michael J
AU  - Fischer MJ
AUID- ORCID: 0000-0002-6345-0813
AD  - Ludwig Boltzmann Institute for Rehabilitation Research, Kurbadstrasse 14, 1100 
      Vienna, Austria.
AD  - Vamed Rehabilitation Center Kitzbuhel, Hornweg 32, 6370 Kitzbuhel, Austria.
AD  - Hannover Medical School MHH, Clinic for Rehabilitation Medicine, 
      Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
LA  - eng
PT  - Journal Article
DEP - 20221003
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC9601141
OTO - NOTNLM
OT  - COPD
OT  - exercise capacity
OT  - outcome measure
OT  - pulmonary rehabilitation
OT  - six-minute walking test
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/28 06:00
MHDA- 2022/10/28 06:01
PMCR- 2022/10/03
CRDT- 2022/10/27 01:16
PHST- 2022/08/15 00:00 [received]
PHST- 2022/09/21 00:00 [revised]
PHST- 2022/09/28 00:00 [accepted]
PHST- 2022/10/27 01:16 [entrez]
PHST- 2022/10/28 06:00 [pubmed]
PHST- 2022/10/28 06:01 [medline]
PHST- 2022/10/03 00:00 [pmc-release]
AID - diagnostics12102402 [pii]
AID - diagnostics-12-02402 [pii]
AID - 10.3390/diagnostics12102402 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2022 Oct 3;12(10):2402. doi: 10.3390/diagnostics12102402.