PMID- 36292278 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221030 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 10 IP - 10 DP - 2022 Sep 22 TI - Classification Algorithms Used in Predicting Glaucoma Progression. LID - 10.3390/healthcare10101831 [doi] LID - 1831 AB - In this paper, various machine learning algorithms were used in order to predict the evolution of open-angle glaucoma (POAG). The datasets were built containing clinical observations and objective measurements made at the Countess of Chester Hospital in the UK and at the "St. Spiridon" Hospital of Iasi, Romania. Using these datasets, different classification problems were proposed. The evaluation of glaucoma progression was conducted based on parameters such as VFI (Visual field index), MD (Mean Deviation), PSD (Pattern standard deviation), and RNFL (Retinal Nerve Fiber Layer). As classification tools, the following algorithms were used: Multilayer Perceptron, Random Forest, Random Tree, C4.5, k-Nearest Neighbors, Support Vector Machine, and Non-Nested Generalized Exemplars. The best results, with an accuracy of over 90%, were obtained with Multilayer Perceptron and Random Forest algorithms. The NNGE algorithm also proved very useful in creating a hierarchy of the input values according to their influence (weight) on the considered outputs. On the other hand, the decision tree algorithms gave us insight into the logic used in their classification, which is of practical importance in obtaining additional information regarding the rationale behind a certain rule or decision. FAU - Tarcoveanu, Filip AU - Tarcoveanu F AD - Ophthalmology Department, Faculty of Medicine, University of Medicine and Pharmacy "Gr. T. Popa" Iasi, University Street No 16, 700115 Iasi, Romania. FAU - Leon, Florin AU - Leon F AUID- ORCID: 0000-0002-1370-9145 AD - Faculty of Automatic Control and Computer Engineering, "Gheorghe Asachi" Technical University of Iasi, 27 Mangeron Street, 700050 Iasi, Romania. FAU - Curteanu, Silvia AU - Curteanu S AD - Department of Chemical Engineering, Faculty of Chemical Engineering and Environmental Protection "Cristofor Simionescu", "Gheorghe Asachi" Technical University of Iasi, 73 Mangeron Street, 700050 Iasi, Romania. FAU - Chiselita, Dorin AU - Chiselita D AD - Ophthalmology Department, Faculty of Medicine, University of Medicine and Pharmacy "Gr. T. Popa" Iasi, University Street No 16, 700115 Iasi, Romania. FAU - Bogdanici, Camelia Margareta AU - Bogdanici CM AUID- ORCID: 0000-0002-9542-7714 AD - Ophthalmology Department, Faculty of Medicine, University of Medicine and Pharmacy "Gr. T. Popa" Iasi, University Street No 16, 700115 Iasi, Romania. FAU - Anton, Nicoleta AU - Anton N AUID- ORCID: 0000-0002-4987-5049 AD - Ophthalmology Department, Faculty of Medicine, University of Medicine and Pharmacy "Gr. T. Popa" Iasi, University Street No 16, 700115 Iasi, Romania. LA - eng PT - Journal Article DEP - 20220922 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC9601916 OTO - NOTNLM OT - artificial intelligence OT - classification algorithms OT - glaucoma OT - machine learning OT - predictions COIS- The authors declare no conflict of interest. EDAT- 2022/10/28 06:00 MHDA- 2022/10/28 06:01 PMCR- 2022/09/22 CRDT- 2022/10/27 01:17 PHST- 2022/08/12 00:00 [received] PHST- 2022/09/18 00:00 [revised] PHST- 2022/09/19 00:00 [accepted] PHST- 2022/10/27 01:17 [entrez] PHST- 2022/10/28 06:00 [pubmed] PHST- 2022/10/28 06:01 [medline] PHST- 2022/09/22 00:00 [pmc-release] AID - healthcare10101831 [pii] AID - healthcare-10-01831 [pii] AID - 10.3390/healthcare10101831 [doi] PST - epublish SO - Healthcare (Basel). 2022 Sep 22;10(10):1831. doi: 10.3390/healthcare10101831.