PMID- 36293512
OWN - NLM
STAT- MEDLINE
DCOM- 20221028
LR  - 20221030
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 20
DP  - 2022 Oct 21
TI  - Inflammation in Pulmonary Hypertension and Edema Induced by Hypobaric Hypoxia 
      Exposure.
LID - 10.3390/ijms232012656 [doi]
LID - 12656
AB  - Exposure to high altitudes generates a decrease in the partial pressure of 
      oxygen, triggering a hypobaric hypoxic condition. This condition produces 
      pathophysiologic alterations in an organism. In the lung, one of the principal 
      responses to hypoxia is the development of hypoxic pulmonary vasoconstriction 
      (HPV), which improves gas exchange. However, when HPV is exacerbated, it induces 
      high-altitude pulmonary hypertension (HAPH). Another important illness in 
      hypobaric hypoxia is high-altitude pulmonary edema (HAPE), which occurs under 
      acute exposure. Several studies have shown that inflammatory processes are 
      activated in high-altitude illnesses, highlighting the importance of the 
      crosstalk between hypoxia and inflammation. The aim of this review is to 
      determine the inflammatory pathways involved in hypobaric hypoxia, to investigate 
      the key role of inflammation in lung pathologies, such as HAPH and HAPE, and to 
      summarize different anti-inflammatory treatment approaches for these 
      high-altitude illnesses. In conclusion, both HAPE and HAPH show an increase in 
      inflammatory cell infiltration (macrophages and neutrophils), cytokine levels 
      (IL-6, TNF-alpha and IL-1beta), chemokine levels (MCP-1), and cell adhesion molecule 
      levels (ICAM-1 and VCAM-1), and anti-inflammatory treatments (decreasing all 
      inflammatory components mentioned above) seem to be promising mitigation 
      strategies for treating lung pathologies associated with high-altitude exposure.
FAU - El Alam, Samia
AU  - El Alam S
AD  - Institute of Health Studies, Arturo Prat University, Iquique 1100000, Chile.
AD  - Institute DECIPHER, German-Chilean Institute for Research on Pulmonary Hypoxia 
      and Its Health Sequelae, Hamburg (Germany) and Iquique (Chile), Avenida Arturo 
      Prat 2120, Iquique 1110939, Chile.
FAU - Pena, Eduardo
AU  - Pena E
AUID- ORCID: 0000-0003-2664-1722
AD  - Institute of Health Studies, Arturo Prat University, Iquique 1100000, Chile.
AD  - Institute DECIPHER, German-Chilean Institute for Research on Pulmonary Hypoxia 
      and Its Health Sequelae, Hamburg (Germany) and Iquique (Chile), Avenida Arturo 
      Prat 2120, Iquique 1110939, Chile.
FAU - Aguilera, Diego
AU  - Aguilera D
AD  - Institute of Health Studies, Arturo Prat University, Iquique 1100000, Chile.
FAU - Siques, Patricia
AU  - Siques P
AUID- ORCID: 0000-0002-4963-195X
AD  - Institute of Health Studies, Arturo Prat University, Iquique 1100000, Chile.
AD  - Institute DECIPHER, German-Chilean Institute for Research on Pulmonary Hypoxia 
      and Its Health Sequelae, Hamburg (Germany) and Iquique (Chile), Avenida Arturo 
      Prat 2120, Iquique 1110939, Chile.
FAU - Brito, Julio
AU  - Brito J
AUID- ORCID: 0000-0002-0050-8774
AD  - Institute of Health Studies, Arturo Prat University, Iquique 1100000, Chile.
AD  - Institute DECIPHER, German-Chilean Institute for Research on Pulmonary Hypoxia 
      and Its Health Sequelae, Hamburg (Germany) and Iquique (Chile), Avenida Arturo 
      Prat 2120, Iquique 1110939, Chile.
LA  - eng
GR  - BIP-400187737-0/FIC GORE-TARAPACA/
PT  - Journal Article
PT  - Review
DEP - 20221021
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Interleukin-6)
RN  - 0 (Cytokines)
RN  - S88TT14065 (Oxygen)
RN  - Pulmonary edema of mountaineers
SB  - IM
MH  - Humans
MH  - *Hypertension, Pulmonary/metabolism
MH  - Intercellular Adhesion Molecule-1
MH  - Altitude
MH  - *Pulmonary Edema/pathology
MH  - Vascular Cell Adhesion Molecule-1
MH  - Tumor Necrosis Factor-alpha
MH  - Interleukin-6
MH  - *Papillomavirus Infections/complications
MH  - *Altitude Sickness/metabolism
MH  - Hypoxia/metabolism
MH  - Edema/complications
MH  - Cytokines
MH  - Inflammation/complications
MH  - Oxygen
PMC - PMC9604159
OTO - NOTNLM
OT  - high altitude
OT  - hypoxia
OT  - inflammation
OT  - pulmonary edema
OT  - pulmonary hypertension
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/28 06:00
MHDA- 2022/10/29 06:00
PMCR- 2022/10/21
CRDT- 2022/10/27 01:24
PHST- 2022/06/28 00:00 [received]
PHST- 2022/08/03 00:00 [revised]
PHST- 2022/08/06 00:00 [accepted]
PHST- 2022/10/27 01:24 [entrez]
PHST- 2022/10/28 06:00 [pubmed]
PHST- 2022/10/29 06:00 [medline]
PHST- 2022/10/21 00:00 [pmc-release]
AID - ijms232012656 [pii]
AID - ijms-23-12656 [pii]
AID - 10.3390/ijms232012656 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Oct 21;23(20):12656. doi: 10.3390/ijms232012656.