PMID- 36294425
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 20
DP  - 2022 Oct 17
TI  - BMI Modifies Increased Mortality Risk of Post-PCI STEMI Patients with AKI.
LID - 10.3390/jcm11206104 [doi]
LID - 6104
AB  - Mortality from acute ST elevation myocardial infarction (STEMI) was significantly 
      reduced with the introduction of percutaneous catheterization intervention (PCI) 
      but remains high in patients who develop acute kidney injury (AKI). Previous 
      studies found overweight to be protective from mortality in patients suffering 
      from STEMI and AKI separately but not as they occur concurrently. This study 
      aimed to establish the relationship between AKI and mortality in STEMI patients 
      after PCI and whether body mass index (BMI) has a protective impact. Between 
      January 2008 and June 2016, two thousand one hundred and forty-one patients with 
      STEMI underwent PCI and were admitted to the Tel Aviv Medical Center Cardiac 
      Intensive Care Unit. Their demographic, laboratory, and clinical data were 
      collected and analyzed. We compared all-cause mortality in patients who developed 
      AKI after PCI for STEMI and those who did not. In total, 178 patients (10%) 
      developed AKI and had higher mortality (p < 0.001). Logistic regression analysis 
      was performed to determine the relationship between AKI, BMI, and mortality. AKI 
      was significantly associated with both 30-day and overall mortality, while BMI 
      had a significant protective effect. Survival analysis found a significant 
      difference in 30-day and overall survival between patients with and without AKI 
      with a significant protective effect of BMI on survival at 30 days. AKI presents 
      a major risk for mortality and poor survival after PCI for STEMI, yet a 
      beneficial effect of increased BMI modifies it.
FAU - Schvartz, Reut
AU  - Schvartz R
AUID- ORCID: 0000-0001-8525-9131
AD  - Department of Anesthesia Pain and Intensive Care, Tel Aviv Sourasky Medical 
      Center, Tel Aviv 62431, Israel.
FAU - Lupu, Lior
AU  - Lupu L
AUID- ORCID: 0000-0003-4873-2887
AD  - Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv 62431, 
      Israel.
FAU - Frydman, Shir
AU  - Frydman S
AD  - Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv 62431, 
      Israel.
FAU - Banai, Shmuel
AU  - Banai S
AD  - Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv 62431, 
      Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 39040, Israel.
FAU - Shacham, Yacov
AU  - Shacham Y
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 39040, Israel.
AD  - Cardiac Intensive Care Unit, Tel Aviv Sourasky Medical Center, Tel Aviv 62431, 
      Israel.
FAU - Gal-Oz, Amir
AU  - Gal-Oz A
AUID- ORCID: 0000-0002-8221-1818
AD  - Department of Anesthesia Pain and Intensive Care, Tel Aviv Sourasky Medical 
      Center, Tel Aviv 62431, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 39040, Israel.
LA  - eng
PT  - Journal Article
DEP - 20221017
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9604849
OTO - NOTNLM
OT  - AKI
OT  - PCI
OT  - STEMI
OT  - obesity paradox
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/28 06:00
MHDA- 2022/10/28 06:01
PMCR- 2022/10/17
CRDT- 2022/10/27 01:30
PHST- 2022/09/07 00:00 [received]
PHST- 2022/09/29 00:00 [revised]
PHST- 2022/10/13 00:00 [accepted]
PHST- 2022/10/27 01:30 [entrez]
PHST- 2022/10/28 06:00 [pubmed]
PHST- 2022/10/28 06:01 [medline]
PHST- 2022/10/17 00:00 [pmc-release]
AID - jcm11206104 [pii]
AID - jcm-11-06104 [pii]
AID - 10.3390/jcm11206104 [doi]
PST - epublish
SO  - J Clin Med. 2022 Oct 17;11(20):6104. doi: 10.3390/jcm11206104.