PMID- 36294499 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230308 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 11 IP - 20 DP - 2022 Oct 19 TI - Safety, Feasibility and Technical Considerations from a Prospective, Observational Study-CIREL: Irinotecan-TACE for CRLM in 152 Patients. LID - 10.3390/jcm11206178 [doi] LID - 6178 AB - CIREL, a prospective, Europe-wide, observational study aimed to assess the real-world feasibility and tolerability of irinotecan-based transarterial chemoembolization (LP-irinotecan TACE) for unresectable colorectal cancer liver metastases with regard to the treatment plan and adverse events (AEs). CIREL enrolled 152 eligible patients (>/=18 years) with liver-only or dominant metastases treated with LP-irinotecan TACE following a multidisciplinary tumor board decision. Data were prospectively collected for baseline, the number of planned and performed sessions, and technical information and safety according to CTCAE 4.03/5.0. Results from 351 analyzed treatment sessions showed technical success for 99% of sessions, and 121 patients (79%) completed all planned sessions. Further, 60% of sessions were performed using opioids, 4% intra-arterial anesthetics, and 25% both. Additionally, 60% of patients experienced at least one peri-interventional AE of any grade; 8% of grade 3-4. Occurrence of AEs was related to larger liver-involvement (p < 0.001), bi-lobar disease (p = 0.002), and larger beads (p < 0.001). Using corticosteroids together with antiemetics showed reduced and lower grade vomiting (p = 0.01). LP-irinotecan TACE was tolerated well and had a high proportion of completed treatment plans. This minimally invasive locoregional treatment can be used together with concomitant systemic therapy or ablation. FAU - Helmberger, Thomas AU - Helmberger T AD - Institut fur Radiologie, Neuroradiologie und Minimal-Invasive Therapie, Munchen Klinik Bogenhausen, Englschalkinger Str. 77, 81925 Munchen, Germany. FAU - Lucatelli, Pierleone AU - Lucatelli P AUID- ORCID: 0000-0002-7448-1404 AD - Vascular and Interventional Radiology Unit, Department of Radiological Oncological and Anatomopathological Sciences, Sapienza University of Rome, 00161 Roma, Italy. FAU - Pereira, Philippe L AU - Pereira PL AD - SLK-Kliniken Heilbronn GmbH, Zentrum fur Radiologie, Minimal-invasive Therapien und Nuklearmedizin, Am Gesundbrunnen 20-26, 74078 Heilbronn, Germany. FAU - Gjoreski, Aleksandar AU - Gjoreski A AD - Diagnostic and Interventional Radiology, General City Hospital "8th September", 1000 Skopje, North Macedonia. FAU - Jovanoska, Ivona AU - Jovanoska I AD - Diagnostic and Interventional Radiology, General City Hospital "8th September", 1000 Skopje, North Macedonia. FAU - Bansaghi, Zoltan AU - Bansaghi Z AD - Medical Imaging Center, Semmelweis University, 1082 Budapest, Hungary. FAU - Spiliopoulos, Stavros AU - Spiliopoulos S AUID- ORCID: 0000-0003-1860-0568 AD - Interventional Radiology Unit, 2nd Department of Radiology, School of Medicine, National and Kapodistrian University of Athens, Rimini 1, 124 62 Athens, Greece. FAU - Carchesio, Francesca AU - Carchesio F AD - Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, UOC di Radiologia Diagnostica ed Interventistica Generale, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00168 Rome, Italy. FAU - Arnold, Dirk AU - Arnold D AD - Asklepios Tumorzentrum Hamburg, AK Altona, 22763 Hamburg, Germany. FAU - Baierl, Andreas AU - Baierl A AD - Department of Statistics and Operations Research, University of Vienna, 1010 Vienna, Austria. FAU - Zeka, Bleranda AU - Zeka B AD - Clinical Research Department, Cardiovascular and Interventional Radiological Society of Europe, Neutorgasse 9, 1010 Vienna, Austria. FAU - Kaufmann, Nathalie C AU - Kaufmann NC AD - Clinical Research Department, Cardiovascular and Interventional Radiological Society of Europe, Neutorgasse 9, 1010 Vienna, Austria. FAU - Taieb, Julien AU - Taieb J AUID- ORCID: 0000-0002-9955-4753 AD - Assistance Publique Hopitaux de Paris, Service d'Hepatogastroenterologie et d'Oncologie Digestive, Hopital Europeen Georges Pompidou, Universite Paris Descartes, Sorbonne Paris-Cite, 75015 Paris, France. FAU - Iezzi, Roberto AU - Iezzi R AUID- ORCID: 0000-0002-2791-481X AD - Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, UOC di Radiologia Diagnostica ed Interventistica Generale, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00168 Rome, Italy. AD - Istituto di Radiodiagnostica, Universita Cattolica del Sacro Cuore, 00168 Rome, Italy. LA - eng GR - Unrestricted scientific grant/Terumo (Belgium)/ PT - Journal Article DEP - 20221019 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC9604674 OTO - NOTNLM OT - CRLM OT - DEBIRI OT - TACE OT - irinotecan OT - mCRC COIS- P.L. Pereira reports the receipt of grants from Siemens Healthineers, Terumo, BTG and Biocompatibles, the receipt of honoraria from Terumo, Sirtex, Angiodynamics, Medtronic, Pharmacept and Guerbet, as well as study grants from BMS, MSD, GSK and Terumo and travel support from Bayer. T. Helmberger received speaker honoraria from SIRTEX Medical Europe. D. Arnold received consulting fees and speaker honoraria from TERUMO, Boston Scientific, SIRTEX Medical Europe and Biocompatibles. J. Taieb reports receiving honoraria from Merck, Roche, Amgen, Lilly, Sanofi, Samsung, MSD, Servier, Celgene, Pierre Fabre; consulting or advisory Role for Roche, Merck KGaA, Amgen, Lilly, MSD, Servier, Pierre Fabre, Sanofi, Samsung; speakers' Bureau for Servier, Amgen, Roche, Sanofi, Merck, Lilly, Pierre Fabre. P. Lucatelli, A. Gjoreski, I. Jovanoska, A. Baierl, R. Iezzi, F. Carchesio, Z. Bansaghi, S. Spiliopoulos, Zeka, and N. Kaufmann report no conflict of interest. EDAT- 2022/10/28 06:00 MHDA- 2022/10/28 06:01 PMCR- 2022/10/19 CRDT- 2022/10/27 01:31 PHST- 2022/09/16 00:00 [received] PHST- 2022/10/15 00:00 [revised] PHST- 2022/10/16 00:00 [accepted] PHST- 2022/10/27 01:31 [entrez] PHST- 2022/10/28 06:00 [pubmed] PHST- 2022/10/28 06:01 [medline] PHST- 2022/10/19 00:00 [pmc-release] AID - jcm11206178 [pii] AID - jcm-11-06178 [pii] AID - 10.3390/jcm11206178 [doi] PST - epublish SO - J Clin Med. 2022 Oct 19;11(20):6178. doi: 10.3390/jcm11206178.