PMID- 36294530 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221030 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 11 IP - 20 DP - 2022 Oct 21 TI - Efficacy of Dupilumab on Different Phenotypes of Adult with Moderate-to-Severe Atopic Dermatitis in Taiwan: A Real-World Study. LID - 10.3390/jcm11206209 [doi] LID - 6209 AB - To determine phenotype-related dupilumab response in adult patients with atopic dermatitis (AD), this multicenter, retrospective study included 111 adults with moderate-to-severe AD in Taiwan, with median age of 31.5 years (18-87) and 71 (64.0%) males. Patients received dupilumab 300 mg per two to three weeks up to 12 months. We found a significant improvement after 4 and 16 weeks of treatment in all patients for all the assessed scores, including eczema area and severity index (EASI) improvement >/=50% (EASI-50) and 75% (EASI-75), EASI reaching minimal clinically important difference (MCID), and Investigator's Global Assessment (IGA) improvement >/=2. Importantly, prior to asthma, early AD onset and 3-week drug intervals were significantly associated with a high proportion of EASI-75 at month 12, while prurigo and lichenoid phenotypes were associated with a lower proportion of EASI-75 at month 12. However, the majority of adverse events were mild in severity. In conclusion, our study results identify phenotype-related dupilumab response at month 12 in adults with moderate-to-severe AD, and we suggest that treatment should not be discontinued until reaching a satisfactory clinical response. FAU - Yang, Chin-Yi AU - Yang CY AD - Department of Dermatology, New Taipei Municipal TuCheng Hospital, New Taipei City 236, Taiwan. AD - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. AD - Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. FAU - Lai, Po-Ju AU - Lai PJ AD - Department of Dermatology, Chung Shan Medical University Hospital, Taichung 402, Taiwan. AD - Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. FAU - Chen, Chun-Bing AU - Chen CB AUID- ORCID: 0000-0002-7378-4235 AD - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. AD - Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - Whole-Genome Research Core Laboratory of Human Diseases, Keelung Chang Gung Memorial Hospital, Keelung 204, Taiwan. AD - Genomic Medicine Core Laboratory, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - Immune-Oncology Center of Excellence, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen 361028, China. AD - School of Medicine, National Tsing Hua University, Hsinchu 300044, Taiwan. FAU - Chan, Tom C AU - Chan TC AD - Department of Dermatology, National Taiwan University Hospital, Taipei 100, Taiwan. AD - Department of Dermatology, National Taiwan University College of Medicine, Taipei 100, Taiwan. FAU - Hui, Rosaline Chung-Yee AU - Hui RC AD - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. AD - Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - Whole-Genome Research Core Laboratory of Human Diseases, Keelung Chang Gung Memorial Hospital, Keelung 204, Taiwan. AD - Genomic Medicine Core Laboratory, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - Immune-Oncology Center of Excellence, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Keelung Chang Gung Memorial Hospital, Keelung 204, Taiwan. FAU - Huang, Yu-Huei AU - Huang YH AD - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. AD - Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. FAU - Tseng, Han-Chi AU - Tseng HC AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. AD - Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan. AD - Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. FAU - Lin, Shang-Hung AU - Lin SH AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. AD - Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan. AD - Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. FAU - Lu, Chun-Wei AU - Lu CW AUID- ORCID: 0000-0002-9341-4012 AD - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. AD - Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - Whole-Genome Research Core Laboratory of Human Diseases, Keelung Chang Gung Memorial Hospital, Keelung 204, Taiwan. AD - Genomic Medicine Core Laboratory, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - Immune-Oncology Center of Excellence, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. FAU - Lee, Hua-En AU - Lee HE AD - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. FAU - Lin, Jing-Yi AU - Lin JY AD - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. AD - Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. FAU - Chi, Min-Hui AU - Chi MH AD - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. AD - Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - Whole-Genome Research Core Laboratory of Human Diseases, Keelung Chang Gung Memorial Hospital, Keelung 204, Taiwan. AD - Department of Dermatology, National Taiwan University College of Medicine, Taipei 100, Taiwan. AD - Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei 106, Taiwan. FAU - Tsai, Ming-Feng AU - Tsai MF AUID- ORCID: 0000-0002-6185-6270 AD - Division of Plastic Surgery, Department of Surgery, Mackay Memorial Hospital, Taipei 104, Taiwan. AD - Department of Medicine, MacKay Medical College, New Taipei 252, Taiwan. AD - Graduate Institute of Biomedical Informatics, Collage of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan. FAU - Hwang, Yih-Shiou AU - Hwang YS AUID- ORCID: 0000-0003-2744-3234 AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. AD - Department of Ophthalmology, Linkou Medical Center, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - Department of Ophthalmology, Jen-Ai Hospital Dali Branch, Taichung 412, Taiwan. AD - Department of Ophthalmology, Xiamen Chang Gung Memorial Hospital, Xiamen 361028, China. FAU - Wang, Chuang-Wei AU - Wang CW AUID- ORCID: 0000-0002-7921-4129 AD - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. AD - Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - Whole-Genome Research Core Laboratory of Human Diseases, Keelung Chang Gung Memorial Hospital, Keelung 204, Taiwan. AD - Genomic Medicine Core Laboratory, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - Immune-Oncology Center of Excellence, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. FAU - Chu, Chia-Yu AU - Chu CY AUID- ORCID: 0000-0002-9370-3279 AD - Department of Dermatology, National Taiwan University Hospital, Taipei 100, Taiwan. AD - Department of Dermatology, National Taiwan University College of Medicine, Taipei 100, Taiwan. FAU - Chung, Wen-Hung AU - Chung WH AD - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. AD - Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - Whole-Genome Research Core Laboratory of Human Diseases, Keelung Chang Gung Memorial Hospital, Keelung 204, Taiwan. AD - Genomic Medicine Core Laboratory, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - Immune-Oncology Center of Excellence, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. AD - Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen 361028, China. LA - eng PT - Journal Article DEP - 20221021 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC9605350 OTO - NOTNLM OT - atopic dermatitis OT - biomarker OT - dupilumab OT - eczema phenotype OT - efficacy COIS- The authors declare no conflict of interest. EDAT- 2022/10/28 06:00 MHDA- 2022/10/28 06:01 PMCR- 2022/10/21 CRDT- 2022/10/27 01:31 PHST- 2022/09/13 00:00 [received] PHST- 2022/09/27 00:00 [revised] PHST- 2022/10/05 00:00 [accepted] PHST- 2022/10/27 01:31 [entrez] PHST- 2022/10/28 06:00 [pubmed] PHST- 2022/10/28 06:01 [medline] PHST- 2022/10/21 00:00 [pmc-release] AID - jcm11206209 [pii] AID - jcm-11-06209 [pii] AID - 10.3390/jcm11206209 [doi] PST - epublish SO - J Clin Med. 2022 Oct 21;11(20):6209. doi: 10.3390/jcm11206209.