PMID- 36294906
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221030
IS  - 2075-1729 (Print)
IS  - 2075-1729 (Electronic)
IS  - 2075-1729 (Linking)
VI  - 12
IP  - 10
DP  - 2022 Sep 21
TI  - Status Epilepticus in Post-Transplantation Hyperammonemia Involves Careful 
      Metabolic Management.
LID - 10.3390/life12101471 [doi]
LID - 1471
AB  - Hyperammonemia is a condition that may result after solid organ transplantation, 
      particularly lung transplantation. However, it is very uncommon for this 
      presentation to occur more than 30 days post-transplantation. Hyperammonemia and 
      the resulting encephalopathy typically manifest with altered sensorium, a 
      clinical situation which is not often included in the differential diagnosis of 
      presumed nonconvulsive status epilepticus (NCSE). Seizures are common among this 
      subset of patients with hyperammonemia and may be refractory to traditional 
      treatments. Evidence of elevated intracranial pressure by invasive monitoring and 
      neuroimaging findings of diffuse cerebral edema are commonly reported. Here we 
      examine the therapeutic importance of identifying the specific cause of 
      hyperammonemic encephalopathy, a condition which may result in status epilepticus 
      and ultimately cerebral edema or even brain death.
FAU - Puram, Vikram Venkata
AU  - Puram VV
AD  - Department of Internal Medicine, Stanford University, Stanford, CA 94304, USA.
AD  - Department of Neurology, University of Minnesota, Minneapolis, MN 55414, USA.
FAU - Berry, Brent
AU  - Berry B
AD  - Department of Neurology, University of Minnesota, Minneapolis, MN 55414, USA.
FAU - Ghannam, Malik
AU  - Ghannam M
AD  - Department of Neurology, University of Minnesota, Minneapolis, MN 55414, USA.
AD  - Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA 
      52242, USA.
FAU - Furuya, Yuka
AU  - Furuya Y
AD  - Department of Pulmonary Medicine, Allergy Critical Care and Sleep Medicine, 
      University of Minnesota, Minneapolis, MN 55414, USA.
LA  - eng
PT  - Case Reports
DEP - 20220921
PL  - Switzerland
TA  - Life (Basel)
JT  - Life (Basel, Switzerland)
JID - 101580444
PMC - PMC9605162
OTO - NOTNLM
OT  - encephalopathy
OT  - lung transplantation
OT  - post-transplantation hyperammonemia
OT  - status epilepticus
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/28 06:00
MHDA- 2022/10/28 06:01
PMCR- 2022/09/21
CRDT- 2022/10/27 01:33
PHST- 2022/07/13 00:00 [received]
PHST- 2022/08/29 00:00 [revised]
PHST- 2022/09/12 00:00 [accepted]
PHST- 2022/10/27 01:33 [entrez]
PHST- 2022/10/28 06:00 [pubmed]
PHST- 2022/10/28 06:01 [medline]
PHST- 2022/09/21 00:00 [pmc-release]
AID - life12101471 [pii]
AID - life-12-01471 [pii]
AID - 10.3390/life12101471 [doi]
PST - epublish
SO  - Life (Basel). 2022 Sep 21;12(10):1471. doi: 10.3390/life12101471.