PMID- 36295797
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221102
IS  - 2218-1989 (Print)
IS  - 2218-1989 (Electronic)
IS  - 2218-1989 (Linking)
VI  - 12
IP  - 10
DP  - 2022 Sep 23
TI  - Early Life Polychlorinated Biphenyl 126 Exposure Disrupts Gut Microbiota and 
      Metabolic Homeostasis in Mice Fed with High-Fat Diet in Adulthood.
LID - 10.3390/metabo12100894 [doi]
LID - 894
AB  - Evidence supports the potential influence of persistent organic pollutants (POPs) 
      on the pathogenesis and progression of obesity and diabetes. Diet-toxicant 
      interactions appear to be important in diet-induced obesity/diabetes; however, 
      the factors influencing this interaction, especially the early life environmental 
      exposure, are unclear. Herein, we investigated the metabolic effects following 
      early life five-day exposure (24 mug/kg body weight per day) to 
      3,3',4,4',5-pentacholorobiphenyl (PCB 126) at four months after exposure in mice 
      fed with control (CTRL) or high-fat diet (HFD). Activation of aryl hydrocarbon 
      receptor (AHR) signaling as well as higher levels of liver nucleotides were 
      observed at 4 months after PCB 126 exposure in mice, independent of diet status. 
      Inflammatory responses including higher levels of serum cytokines and adipose 
      inflammatory gene expression caused by early life PCB 126 were observed only in 
      HFD-fed mice in adulthood. Notably, early life PCB 126 exposure worsened 
      HFD-induced impaired glucose homeostasis characterized by glucose intolerance and 
      elevated gluconeogenesis and tricarboxylic acid (TCA) cycle flux without 
      worsening the effects of HFD related to adiposity in adulthood. Furthermore, 
      early life PCB 126 exposure resulted in diet-dependent changes in bacterial 
      community structure and function later in life, as indicated by metagenomic and 
      metabolomic analyses. These data contribute to a more comprehensive understanding 
      of the interactions between diet and early life environmental chemical exposure.
FAU - Tian, Yuan
AU  - Tian Y
AUID- ORCID: 0000-0001-6174-3359
AD  - Department of Veterinary and Biomedical Sciences, The Pennsylvania State 
      University, University Park, PA 16802, USA.
FAU - Rimal, Bipin
AU  - Rimal B
AD  - Department of Veterinary and Biomedical Sciences, The Pennsylvania State 
      University, University Park, PA 16802, USA.
FAU - Gui, Wei
AU  - Gui W
AD  - Huck Institutes of the Life Sciences, The Pennsylvania State University, 
      University Park, PA 16802, USA.
FAU - Koo, Imhoi
AU  - Koo I
AUID- ORCID: 0000-0002-5816-0627
AD  - Department of Veterinary and Biomedical Sciences, The Pennsylvania State 
      University, University Park, PA 16802, USA.
FAU - Smith, Philip B
AU  - Smith PB
AD  - Huck Institutes of the Life Sciences, The Pennsylvania State University, 
      University Park, PA 16802, USA.
FAU - Yokoyama, Shigetoshi
AU  - Yokoyama S
AUID- ORCID: 0000-0003-4175-0548
AD  - Department of Veterinary and Biomedical Sciences, The Pennsylvania State 
      University, University Park, PA 16802, USA.
FAU - Patterson, Andrew D
AU  - Patterson AD
AUID- ORCID: 0000-0003-2073-0070
AD  - Department of Veterinary and Biomedical Sciences, The Pennsylvania State 
      University, University Park, PA 16802, USA.
LA  - eng
GR  - Project PEN047702 and Accession number 1009993/the USDA National Institute of 
      Food and Federal Appropriations/
GR  - S10 OD021750 (ADP)/NH/NIH HHS/United States
GR  - R01 ES028288/ES/NIEHS NIH HHS/United States
GR  - S10 OD021750/OD/NIH HHS/United States
GR  - R01 ES028288 (ADP)/NH/NIH HHS/United States
PT  - Journal Article
DEP - 20220923
PL  - Switzerland
TA  - Metabolites
JT  - Metabolites
JID - 101578790
PMC - PMC9609008
OTO - NOTNLM
OT  - 3,3',4,4',5-pentacholorobiphenyl
OT  - early life exposure
OT  - glucose homeostasis
OT  - gut microbiota
OT  - high-fat diet
OT  - metabolomics
OT  - obesity
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/28 06:00
MHDA- 2022/10/28 06:01
PMCR- 2022/09/23
CRDT- 2022/10/27 01:39
PHST- 2022/08/23 00:00 [received]
PHST- 2022/09/14 00:00 [revised]
PHST- 2022/09/20 00:00 [accepted]
PHST- 2022/10/27 01:39 [entrez]
PHST- 2022/10/28 06:00 [pubmed]
PHST- 2022/10/28 06:01 [medline]
PHST- 2022/09/23 00:00 [pmc-release]
AID - metabo12100894 [pii]
AID - metabolites-12-00894 [pii]
AID - 10.3390/metabo12100894 [doi]
PST - epublish
SO  - Metabolites. 2022 Sep 23;12(10):894. doi: 10.3390/metabo12100894.