PMID- 3629596
OWN - NLM
STAT- MEDLINE
DCOM- 19871016
LR  - 20190727
IS  - 0041-008X (Print)
IS  - 0041-008X (Linking)
VI  - 90
IP  - 2
DP  - 1987 Sep 15
TI  - Teratogenicity of three polychlorinated dibenzofurans in C57BL/6N mice.
PG  - 206-16
AB  - Polychlorinated dibenzofurans (PCDFs) are widespread environmental contaminants 
      which have been detected in human tissues and implicated in several poisoning 
      incidents. Their toxic effects are similar to those observed with other related 
      halogenated aromatic hydrocarbons such as TCDD. The teratogenic effects of three 
      PCDFs, 1,2,3,7,8-pentachlorodibenzofuran (1-PeCDF), 
      2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF), and 
      1,2,3,4,7,8-hexachlorodibenzofuran (HCDF), were assessed in C57BL/6N mice. 
      Pregnant mice were exposed on Gestation Days 10-13 to 10 ml corn oil/kg 
      containing PCDFs. The dams were killed on Gestation Day 18 and maternal and fetal 
      toxicity were assessed. All three compounds were highly teratogenic, with very 
      steep and parallel dose-response curves for the two diagnostic indicators of 
      dioxin-like teratogenicity, hydronephrosis, and cleft palate. 4-PeCDF was the 
      most teratogenic with an ED50 of 36 micrograms/kg for cleft palate and 7 
      micrograms/kg for hydronephrosis. 4-PeCDF was approximately 4 times as potent as 
      1-PeCDF and 10 times as potent as HCDF. The teratogenic responses occurred at a 
      dose below that where any obvious maternal or fetal toxicity was detected. Thus, 
      these three compounds cause teratogenic responses similar to those seen with TCDD 
      but are only 1/10 to 1/100 as potent.
FAU - Birnbaum, L S
AU  - Birnbaum LS
FAU - Harris, M W
AU  - Harris MW
FAU - Barnhart, E R
AU  - Barnhart ER
FAU - Morrissey, R E
AU  - Morrissey RE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Benzofurans)
RN  - 0 (Dibenzofurans, Polychlorinated)
RN  - 0 (Polychlorinated Dibenzodioxins)
SB  - IM
MH  - Abnormalities, Drug-Induced/*etiology
MH  - Animals
MH  - Benzofurans/*toxicity
MH  - Body Weight/drug effects
MH  - Cleft Palate/chemically induced
MH  - Dibenzofurans, Polychlorinated
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Hydronephrosis/chemically induced
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Polychlorinated Dibenzodioxins/toxicity
MH  - Pregnancy
EDAT- 1987/09/15 00:00
MHDA- 1987/09/15 00:01
CRDT- 1987/09/15 00:00
PHST- 1987/09/15 00:00 [pubmed]
PHST- 1987/09/15 00:01 [medline]
PHST- 1987/09/15 00:00 [entrez]
AID - 10.1016/0041-008x(87)90328-0 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 1987 Sep 15;90(2):206-16. doi: 
      10.1016/0041-008x(87)90328-0.