PMID- 36296129
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221030
IS  - 2072-666X (Print)
IS  - 2072-666X (Electronic)
IS  - 2072-666X (Linking)
VI  - 13
IP  - 10
DP  - 2022 Oct 19
TI  - Design of Improved Flow-Focusing Microchannel with Constricted Continuous Phase 
      Inlet and Study of Fluid Flow Characteristics.
LID - 10.3390/mi13101776 [doi]
LID - 1776
AB  - This paper proposed an improved flow-focusing microchannel with a constricted 
      continuous phase inlet to increase microbubble generation frequency and reduce 
      microbubbles' diameter. The design variables were obtained by Latin hypercube 
      sampling, and the radial basis function (RBF) surrogate model was used to 
      establish the relationship between the objective function (microbubble diameter 
      and generation frequency) and the design variables. Moreover, the optimized 
      design of the nondominated sorting genetic algorithm II (NSGA-II) algorithm was 
      carried out. Finally, the optimization results were verified by numerical 
      simulations and compared with those of traditional microchannels. The results 
      showed that dripping and squeezing regimes existed in the two microchannels. The 
      constricted continuous phase inlet enhanced the flow-focusing effect of the 
      improved microchannel. The diameter of microbubbles obtained from the improved 
      microchannel was reduced from 2.8141 to 1.6949 mum, and the generation frequency 
      was increased from 64.077 to 175.438 kHz at the same capillary numbers (Ca) 
      compared with the traditional microchannel. According to the fitted linear 
      function, it is known that the slope of decreasing microbubble diameter with 
      increasing Ca number and the slope of increasing generation frequency with 
      increasing Ca number are greater in the improved microchannel compared with those 
      in the traditional microchannel.
FAU - Wang, Zhaohui
AU  - Wang Z
AD  - Key Laboratory of Metallurgical Equipment and Control Technology of Ministry of 
      Education, Wuhan University of Science and Technology, Wuhan 430081, China.
FAU - Ding, Weibing
AU  - Ding W
AD  - Key Laboratory of Metallurgical Equipment and Control Technology of Ministry of 
      Education, Wuhan University of Science and Technology, Wuhan 430081, China.
FAU - Fan, Yiwei
AU  - Fan Y
AD  - Key Laboratory of Metallurgical Equipment and Control Technology of Ministry of 
      Education, Wuhan University of Science and Technology, Wuhan 430081, China.
FAU - Wang, Jian
AU  - Wang J
AD  - Key Laboratory of Metallurgical Equipment and Control Technology of Ministry of 
      Education, Wuhan University of Science and Technology, Wuhan 430081, China.
FAU - Chen, Jie
AU  - Chen J
AD  - The State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang 
      University, Hangzhou 310027, China.
FAU - Wang, Hongxia
AU  - Wang H
AD  - College of Mechanical Engineering, Hubei University of Automotive Technology, 
      Shiyan 442002, China.
LA  - eng
GR  - No. 51875419/National Natural Science Foundation of China/
GR  - GZKF-202122/Open Foundation of the State Key Laboratory of Fluid Power and 
      Mechatronic Systems/
GR  - 2021CFB495/Natural Science Foundation of Hubei Province/
GR  - 2015233/Hubei Higher Education Research Project/
PT  - Journal Article
DEP - 20221019
PL  - Switzerland
TA  - Micromachines (Basel)
JT  - Micromachines
JID - 101640903
PMC - PMC9609089
OTO - NOTNLM
OT  - RBF model
OT  - flow characteristics
OT  - flow-focusing microchannel
OT  - microbubbles
OT  - optimal design
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/28 06:00
MHDA- 2022/10/28 06:01
PMCR- 2022/10/19
CRDT- 2022/10/27 01:41
PHST- 2022/09/09 00:00 [received]
PHST- 2022/10/07 00:00 [revised]
PHST- 2022/10/17 00:00 [accepted]
PHST- 2022/10/27 01:41 [entrez]
PHST- 2022/10/28 06:00 [pubmed]
PHST- 2022/10/28 06:01 [medline]
PHST- 2022/10/19 00:00 [pmc-release]
AID - mi13101776 [pii]
AID - micromachines-13-01776 [pii]
AID - 10.3390/mi13101776 [doi]
PST - epublish
SO  - Micromachines (Basel). 2022 Oct 19;13(10):1776. doi: 10.3390/mi13101776.