PMID- 36297095
OWN - NLM
STAT- MEDLINE
DCOM- 20221028
LR  - 20240306
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 20
DP  - 2022 Oct 20
TI  - The Association between Circulating Branched Chain Amino Acids and the Temporal 
      Risk of Developing Type 2 Diabetes Mellitus: A Systematic Review & Meta-Analysis.
LID - 10.3390/nu14204411 [doi]
LID - 4411
AB  - Introduction: Recent studies have concluded that elevated circulating branched 
      chain amino acids (BCAA) are associated with the pathogenesis of type 2 diabetes 
      mellitus (T2DM) and obesity. However, the development of this association over 
      time and the quantification of the strength of this association for individual 
      BCAAs prior to T2DM diagnosis remains unexplored. Methods: A systematic search 
      was conducted using the Healthcare Databases Advance Search (HDAS) via the 
      National Institute for Health and Care Excellence (NICE) website. The data 
      sources included EMBASE, MEDLINE and PubMed for all papers from inception until 
      November 2021. Nine studies were identified in this systematic review and 
      meta-analysis. Stratification was based on follow-up times (0-6, 6-12 and 12 or 
      more years) and controlling of body mass index (BMI) through the specific 
      assessment of overweight cohorts was also undertaken. Results: The meta-analysis 
      revealed a statistically significant positive association between BCAA 
      concentrations and the development of T2DM, with valine OR = 2.08 (95% CI = 
      2.04-2.12, p < 0.00001), leucine OR = 2.25 (95% CI = 1.76-2.87, p < 0.00001) and 
      isoleucine OR = 2.12, 95% CI = 2.00-2.25, p < 0.00001. In addition, we 
      demonstrated a positive consistent temporal association between circulating BCAA 
      levels and the risk of developing T2DM with differentials in the respective 
      follow-up times of 0-6 years, 6-12 years and >/=12 years follow-up for valine (OR = 
      2.08, 1.86 and 2.14, p < 0.05 each), leucine (OR = 2.10, 2.25 and 2.16, p < 0.05 
      each) and isoleucine (OR = 2.12, 1.90 and 2.16, p < 0.05 each) demonstrated. 
      Conclusion: Plasma BCAA concentrations are associated with T2DM incidence across 
      all temporal subgroups. We suggest the potential utility of BCAAs as an early 
      biomarker for T2DM irrespective of follow-up time.
FAU - Ramzan, Imran
AU  - Ramzan I
AD  - Clinical, Metabolic and Molecular Physiology Research Group, MRC-Versus Arthritis 
      Centre for Musculoskeletal Ageing Research, Royal Derby Hospital Centre, 
      University of Nottingham, Derby DE22 6DT, UK.
AD  - National Institute for Health Research (NIHR), Nottingham Biomedical Research 
      Centre, Nottingham NG7 2UH, UK.
FAU - Ardavani, Arash
AU  - Ardavani A
AD  - Clinical, Metabolic and Molecular Physiology Research Group, MRC-Versus Arthritis 
      Centre for Musculoskeletal Ageing Research, Royal Derby Hospital Centre, 
      University of Nottingham, Derby DE22 6DT, UK.
AD  - National Institute for Health Research (NIHR), Nottingham Biomedical Research 
      Centre, Nottingham NG7 2UH, UK.
FAU - Vanweert, Froukje
AU  - Vanweert F
AUID- ORCID: 0000-0002-0005-8523
AD  - Department of Nutrition and Movement Sciences, NUTRIM, School of Nutrition and 
      Translational Research in Metabolism, Maastricht University, 6229 ER Maastricht, 
      The Netherlands.
FAU - Mellett, Aisling
AU  - Mellett A
AD  - Clinical, Metabolic and Molecular Physiology Research Group, MRC-Versus Arthritis 
      Centre for Musculoskeletal Ageing Research, Royal Derby Hospital Centre, 
      University of Nottingham, Derby DE22 6DT, UK.
AD  - School of Agriculture and Food Science, Agriculture and Food Science Centre, 
      University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.
FAU - Atherton, Philip J
AU  - Atherton PJ
AUID- ORCID: 0000-0002-7286-046X
AD  - Clinical, Metabolic and Molecular Physiology Research Group, MRC-Versus Arthritis 
      Centre for Musculoskeletal Ageing Research, Royal Derby Hospital Centre, 
      University of Nottingham, Derby DE22 6DT, UK.
AD  - National Institute for Health Research (NIHR), Nottingham Biomedical Research 
      Centre, Nottingham NG7 2UH, UK.
FAU - Idris, Iskandar
AU  - Idris I
AD  - Clinical, Metabolic and Molecular Physiology Research Group, MRC-Versus Arthritis 
      Centre for Musculoskeletal Ageing Research, Royal Derby Hospital Centre, 
      University of Nottingham, Derby DE22 6DT, UK.
AD  - National Institute for Health Research (NIHR), Nottingham Biomedical Research 
      Centre, Nottingham NG7 2UH, UK.
LA  - eng
GR  - MR/P021220/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20221020
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Amino Acids, Branched-Chain)
RN  - 04Y7590D77 (Isoleucine)
RN  - GMW67QNF9C (Leucine)
RN  - 0 (Biomarkers)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Humans
MH  - *Amino Acids, Branched-Chain
MH  - *Diabetes Mellitus, Type 2/diagnosis/epidemiology/etiology
MH  - Isoleucine
MH  - Leucine
MH  - Biomarkers
MH  - Valine
PMC - PMC9610746
OTO - NOTNLM
OT  - BCAA
OT  - BMI
OT  - T2DM
OT  - branch chain amino acid
OT  - insulin resistance
OT  - isoleucine
OT  - leucine
OT  - obese
OT  - obesity
OT  - overweight
OT  - type 2 diabetes mellitus
OT  - valine
COIS- Ramzan I: No disclosures. Ardavani A: No disclosures. Vanweert F: No disclosures. 
      Mellett A: No disclosures. Atherton PJ: No disclosures. Idris I: No disclosures.
EDAT- 2022/10/28 06:00
MHDA- 2022/10/29 06:00
PMCR- 2022/10/20
CRDT- 2022/10/27 01:48
PHST- 2022/09/05 00:00 [received]
PHST- 2022/10/11 00:00 [revised]
PHST- 2022/10/11 00:00 [accepted]
PHST- 2022/10/27 01:48 [entrez]
PHST- 2022/10/28 06:00 [pubmed]
PHST- 2022/10/29 06:00 [medline]
PHST- 2022/10/20 00:00 [pmc-release]
AID - nu14204411 [pii]
AID - nutrients-14-04411 [pii]
AID - 10.3390/nu14204411 [doi]
PST - epublish
SO  - Nutrients. 2022 Oct 20;14(20):4411. doi: 10.3390/nu14204411.