PMID- 36297746
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221030
IS  - 2223-7747 (Print)
IS  - 2223-7747 (Electronic)
IS  - 2223-7747 (Linking)
VI  - 11
IP  - 20
DP  - 2022 Oct 14
TI  - Recent Updates on Phytoconstituent Alpha-Glucosidase Inhibitors: An Approach 
      towards the Treatment of Type Two Diabetes.
LID - 10.3390/plants11202722 [doi]
LID - 2722
AB  - Diabetes is a common metabolic disorder marked by unusually high plasma glucose 
      levels, which can lead to serious consequences such as retinopathy, diabetic 
      neuropathy and cardiovascular disease. One of the most efficient ways to reduce 
      postprandial hyperglycemia (PPHG) in diabetes mellitus, especially 
      insulin-independent diabetes mellitus, is to lower the amount of glucose that is 
      absorbed by inhibiting carbohydrate hydrolyzing enzymes in the digestive system, 
      such as alpha-glucosidase and alpha-amylase. alpha-Glucosidase is a crucial enzyme that 
      catalyzes the final stage of carbohydrate digestion. As a result, alpha-glucosidase 
      inhibitors can slow D-glucose release from complex carbohydrates and delay 
      glucose absorption, resulting in lower postprandial plasma glucose levels and 
      control of PPHG. Many attempts have been made in recent years to uncover 
      efficient alpha-glucosidase inhibitors from natural sources to build a physiologic 
      functional diet or lead compound for diabetes treatment. Many phytoconstituent 
      alpha-glucosidase inhibitors have been identified from plants, including alkaloids, 
      flavonoids, anthocyanins, terpenoids, phenolic compounds, glycosides and others. 
      The current review focuses on the most recent updates on different 
      traditional/medicinal plant extracts and isolated compounds' biological activity 
      that can help in the development of potent therapeutic medications with greater 
      efficacy and safety for the treatment of type 2 diabetes or to avoid PPHG. For 
      this purpose, we provide a summary of the latest scientific literature findings 
      on plant extracts as well as plant-derived bioactive compounds as potential 
      alpha-glucosidase inhibitors with hypoglycemic effects. Moreover, the review 
      elucidates structural insights of the key drug target, alpha-glucosidase enzymes, and 
      its interaction with different inhibitors.
FAU - Kashtoh, Hamdy
AU  - Kashtoh H
AD  - Department of Biotechnology, Yeungnam University, Gyeongsan 38541, Korea.
FAU - Baek, Kwang-Hyun
AU  - Baek KH
AD  - Department of Biotechnology, Yeungnam University, Gyeongsan 38541, Korea.
LA  - eng
GR  - NRF-2021R1F1A1060297/National Research Foundation of Korea/
PT  - Journal Article
PT  - Review
DEP - 20221014
PL  - Switzerland
TA  - Plants (Basel)
JT  - Plants (Basel, Switzerland)
JID - 101596181
PMC - PMC9612090
OTO - NOTNLM
OT  - natural compounds
OT  - postprandial hyperglycemia
OT  - type 2 diabetes
OT  - alpha-glucosidase
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/28 06:00
MHDA- 2022/10/28 06:01
PMCR- 2022/10/14
CRDT- 2022/10/27 01:52
PHST- 2022/09/15 00:00 [received]
PHST- 2022/10/07 00:00 [revised]
PHST- 2022/10/11 00:00 [accepted]
PHST- 2022/10/27 01:52 [entrez]
PHST- 2022/10/28 06:00 [pubmed]
PHST- 2022/10/28 06:01 [medline]
PHST- 2022/10/14 00:00 [pmc-release]
AID - plants11202722 [pii]
AID - plants-11-02722 [pii]
AID - 10.3390/plants11202722 [doi]
PST - epublish
SO  - Plants (Basel). 2022 Oct 14;11(20):2722. doi: 10.3390/plants11202722.