PMID- 36300597
OWN - NLM
STAT- MEDLINE
DCOM- 20230419
LR  - 20230428
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Linking)
VI  - 33
IP  - 8
DP  - 2023 Apr 4
TI  - Individualized morphometric similarity predicts body mass index and food approach 
      behavior in school-age children.
PG  - 4794-4805
LID - 10.1093/cercor/bhac380 [doi]
AB  - Childhood obesity is associated with alterations in brain structure. Previous 
      studies generally used a single structural index to characterize the relationship 
      between body mass index(BMI) and brain structure, which could not describe the 
      alterations of structural covariance between brain regions. To cover this 
      research gap, this study utilized two independent datasets with brain structure 
      profiles and BMI of 155 school-aged children. Connectome-based predictive 
      modeling(CPM) was used to explore whether children's BMI is reliably predictable 
      by the novel individualized morphometric similarity network(MSN). We revealed the 
      MSN can predict the BMI in school-age children with good generalizability to 
      unseen dataset. Moreover, these revealed significant brain structure covariant 
      networks can further predict children's food approach behavior. The positive 
      predictive networks mainly incorporated connections between the frontoparietal 
      network(FPN) and the visual network(VN), between the FPN and the limbic 
      network(LN), between the default mode network(DMN) and the LN. The negative 
      predictive network primarily incorporated connections between the FPN and DMN. 
      These results suggested that the incomplete integration of the high-order brain 
      networks and the decreased dedifferentiation of the high-order networks to the 
      primary reward networks can be considered as a core structural basis of the 
      imbalance between inhibitory control and reward processing in childhood obesity.
CI  - (c) The Author(s) 2022. Published by Oxford University Press. All rights reserved. 
      For permissions, please e-mail: journals.permissions@oup.com.
FAU - Wang, Yulin
AU  - Wang Y
AUID- ORCID: 0000-0002-5320-3421
AD  - Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, 
      Chongqing, 400715, China.
AD  - Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of 
      Psychology, Southwest University, Chongqing, 400715, China.
FAU - Dong, Debo
AU  - Dong D
AD  - Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of 
      Psychology, Southwest University, Chongqing, 400715, China.
AD  - Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research 
      Centre Julich, Julich, Germany.
FAU - Chen, Ximei
AU  - Chen X
AD  - Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of 
      Psychology, Southwest University, Chongqing, 400715, China.
FAU - Gao, Xiao
AU  - Gao X
AD  - Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of 
      Psychology, Southwest University, Chongqing, 400715, China.
FAU - Liu, Yong
AU  - Liu Y
AD  - Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of 
      Psychology, Southwest University, Chongqing, 400715, China.
FAU - Xiao, Mingyue
AU  - Xiao M
AD  - Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of 
      Psychology, Southwest University, Chongqing, 400715, China.
FAU - Guo, Cheng
AU  - Guo C
AD  - Research Center of Mental Health Education, Faculty of Psychology, Southwest 
      University, Chongqing, 400715, Germany.
FAU - Chen, Hong
AU  - Chen H
AD  - Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of 
      Psychology, Southwest University, Chongqing, 400715, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
SB  - IM
MH  - Humans
MH  - Child
MH  - Body Mass Index
MH  - *Pediatric Obesity
MH  - Brain/diagnostic imaging
MH  - *Connectome
MH  - Food
MH  - Magnetic Resonance Imaging
OTO - NOTNLM
OT  - BMI
OT  - CPM
OT  - Childhood obesity
OT  - Individualized morphometric similarity
OT  - food approach
EDAT- 2022/10/28 06:00
MHDA- 2023/04/19 06:41
CRDT- 2022/10/27 06:42
PHST- 2022/07/19 00:00 [received]
PHST- 2022/08/20 00:00 [revised]
PHST- 2022/08/22 00:00 [accepted]
PHST- 2023/04/19 06:41 [medline]
PHST- 2022/10/28 06:00 [pubmed]
PHST- 2022/10/27 06:42 [entrez]
AID - 6774652 [pii]
AID - 10.1093/cercor/bhac380 [doi]
PST - ppublish
SO  - Cereb Cortex. 2023 Apr 4;33(8):4794-4805. doi: 10.1093/cercor/bhac380.