PMID- 36300974
OWN - NLM
STAT- MEDLINE
DCOM- 20221104
LR  - 20221104
IS  - 1533-4406 (Electronic)
IS  - 0028-4793 (Linking)
VI  - 387
IP  - 17
DP  - 2022 Oct 27
TI  - Neonatal Docosahexaenoic Acid in Preterm Infants and Intelligence at 5 Years.
PG  - 1579-1588
LID - 10.1056/NEJMoa2206868 [doi]
AB  - BACKGROUND: Docosahexaenoic acid (DHA) is a component of neural tissue. Because 
      its accretion into the brain is greatest during the final trimester of pregnancy, 
      infants born before 29 weeks' gestation do not receive the normal supply of DHA. 
      The effect of this deficiency on subsequent cognitive development is not well 
      understood. METHODS: We assessed general intelligence at 5 years in children who 
      had been enrolled in a trial of neonatal DHA supplementation to prevent 
      bronchopulmonary dysplasia. In the previous trial, infants born before 29 weeks' 
      gestation had been randomly assigned in a 1:1 ratio to receive an enteral 
      emulsion that provided 60 mg of DHA per kilogram of body weight per day or a 
      control emulsion from the first 3 days of enteral feeds until 36 weeks of 
      postmenstrual age or discharge home, whichever occurred first. Children from 5 of 
      the 13 centers in the original trial were invited to undergo assessment with the 
      Wechsler Preschool and Primary Scale of Intelligence (WPPSI) at 5 years of 
      corrected age. The primary outcome was the full-scale intelligence quotient 
      (FSIQ) score. Secondary outcomes included the components of WPPSI. RESULTS: A 
      total of 1273 infants underwent randomization in the original trial; of the 656 
      surviving children who had undergone randomization at the centers included in 
      this follow-up study, 480 (73%) had an FSIQ score available - 241 in the DHA 
      group and 239 in the control group. After imputation of missing data, the mean 
      (+/-SD) FSIQ scores were 95.4+/-17.3 in the DHA group and 91.9+/-19.1 in the control 
      group (adjusted difference, 3.45; 95% confidence interval, 0.38 to 6.53; 
      P = 0.03). The results for secondary outcomes generally did not support that 
      obtained for the primary outcome. Adverse events were similar in the two groups. 
      CONCLUSIONS: In infants born before 29 weeks' gestation who had been enrolled in 
      a trial to assess the effect of DHA supplementation on bronchopulmonary 
      dysplasia, the use of an enteral DHA emulsion until 36 weeks of postmenstrual age 
      was associated with modestly higher FSIQ scores at 5 years of age than control 
      feeding. (Funded by the Australian National Health and Medical Research Council 
      and Nu-Mega Ingredients; N3RO Australian New Zealand Clinical Trials Registry 
      number, ACTRN12612000503820.).
CI  - Copyright (c) 2022 Massachusetts Medical Society.
FAU - Gould, Jacqueline F
AU  - Gould JF
AD  - From SAHMRI Women and Kids, South Australian Health and Medical Research 
      Institute (J.F.G., M.M., R.A.G., T.R.S., A.J.M., K.P.B., J.M.B., C.T.C.), the 
      Schools of Medicine (J.F.G., M.M., A.J.M., K.P.B., C.T.C.), Psychology (J.F.G.), 
      Agriculture, Food, and Wine (R.A.G.), and Public Health (T.R.S.), University of 
      Adelaide, and the Department of Neonatal Medicine, Women's and Children's 
      Hospital (A.J.M.), Adelaide, SA, Newborn Research, Royal Women's Hospital 
      (J.L.Y.C., P.G.D., L.W.D.), the Murdoch Children's Research Institute (P.J.A., 
      J.L.Y.C., P.G.D., L.W.D.), and the Departments of Obstetrics and Gynaecology 
      (J.L.Y.C., P.G.D., L.W.D.) and Paediatrics (L.W.D.), University of Melbourne, the 
      School of Psychological Sciences, Monash University (P.J.A.), and the Department 
      of Paediatrics, Mercy Hospital for Women (G.F.O.), Melbourne, VIC, King Edward 
      Memorial Hospital, Subiaco, WA (M.S.), Newborn Medicine, Centre for Neonatal 
      Research and Education, University of Western Australia, Perth, WA (M.S., K.S.), 
      and the Neonatal Intensive Care Unit, John Hunter Children's Hospital, New 
      Lambton Heights, NSW (J.T.) - all in Australia.
FAU - Makrides, Maria
AU  - Makrides M
AD  - From SAHMRI Women and Kids, South Australian Health and Medical Research 
      Institute (J.F.G., M.M., R.A.G., T.R.S., A.J.M., K.P.B., J.M.B., C.T.C.), the 
      Schools of Medicine (J.F.G., M.M., A.J.M., K.P.B., C.T.C.), Psychology (J.F.G.), 
      Agriculture, Food, and Wine (R.A.G.), and Public Health (T.R.S.), University of 
      Adelaide, and the Department of Neonatal Medicine, Women's and Children's 
      Hospital (A.J.M.), Adelaide, SA, Newborn Research, Royal Women's Hospital 
      (J.L.Y.C., P.G.D., L.W.D.), the Murdoch Children's Research Institute (P.J.A., 
      J.L.Y.C., P.G.D., L.W.D.), and the Departments of Obstetrics and Gynaecology 
      (J.L.Y.C., P.G.D., L.W.D.) and Paediatrics (L.W.D.), University of Melbourne, the 
      School of Psychological Sciences, Monash University (P.J.A.), and the Department 
      of Paediatrics, Mercy Hospital for Women (G.F.O.), Melbourne, VIC, King Edward 
      Memorial Hospital, Subiaco, WA (M.S.), Newborn Medicine, Centre for Neonatal 
      Research and Education, University of Western Australia, Perth, WA (M.S., K.S.), 
      and the Neonatal Intensive Care Unit, John Hunter Children's Hospital, New 
      Lambton Heights, NSW (J.T.) - all in Australia.
FAU - Gibson, Robert A
AU  - Gibson RA
AD  - From SAHMRI Women and Kids, South Australian Health and Medical Research 
      Institute (J.F.G., M.M., R.A.G., T.R.S., A.J.M., K.P.B., J.M.B., C.T.C.), the 
      Schools of Medicine (J.F.G., M.M., A.J.M., K.P.B., C.T.C.), Psychology (J.F.G.), 
      Agriculture, Food, and Wine (R.A.G.), and Public Health (T.R.S.), University of 
      Adelaide, and the Department of Neonatal Medicine, Women's and Children's 
      Hospital (A.J.M.), Adelaide, SA, Newborn Research, Royal Women's Hospital 
      (J.L.Y.C., P.G.D., L.W.D.), the Murdoch Children's Research Institute (P.J.A., 
      J.L.Y.C., P.G.D., L.W.D.), and the Departments of Obstetrics and Gynaecology 
      (J.L.Y.C., P.G.D., L.W.D.) and Paediatrics (L.W.D.), University of Melbourne, the 
      School of Psychological Sciences, Monash University (P.J.A.), and the Department 
      of Paediatrics, Mercy Hospital for Women (G.F.O.), Melbourne, VIC, King Edward 
      Memorial Hospital, Subiaco, WA (M.S.), Newborn Medicine, Centre for Neonatal 
      Research and Education, University of Western Australia, Perth, WA (M.S., K.S.), 
      and the Neonatal Intensive Care Unit, John Hunter Children's Hospital, New 
      Lambton Heights, NSW (J.T.) - all in Australia.
FAU - Sullivan, Thomas R
AU  - Sullivan TR
AD  - From SAHMRI Women and Kids, South Australian Health and Medical Research 
      Institute (J.F.G., M.M., R.A.G., T.R.S., A.J.M., K.P.B., J.M.B., C.T.C.), the 
      Schools of Medicine (J.F.G., M.M., A.J.M., K.P.B., C.T.C.), Psychology (J.F.G.), 
      Agriculture, Food, and Wine (R.A.G.), and Public Health (T.R.S.), University of 
      Adelaide, and the Department of Neonatal Medicine, Women's and Children's 
      Hospital (A.J.M.), Adelaide, SA, Newborn Research, Royal Women's Hospital 
      (J.L.Y.C., P.G.D., L.W.D.), the Murdoch Children's Research Institute (P.J.A., 
      J.L.Y.C., P.G.D., L.W.D.), and the Departments of Obstetrics and Gynaecology 
      (J.L.Y.C., P.G.D., L.W.D.) and Paediatrics (L.W.D.), University of Melbourne, the 
      School of Psychological Sciences, Monash University (P.J.A.), and the Department 
      of Paediatrics, Mercy Hospital for Women (G.F.O.), Melbourne, VIC, King Edward 
      Memorial Hospital, Subiaco, WA (M.S.), Newborn Medicine, Centre for Neonatal 
      Research and Education, University of Western Australia, Perth, WA (M.S., K.S.), 
      and the Neonatal Intensive Care Unit, John Hunter Children's Hospital, New 
      Lambton Heights, NSW (J.T.) - all in Australia.
FAU - McPhee, Andrew J
AU  - McPhee AJ
AD  - From SAHMRI Women and Kids, South Australian Health and Medical Research 
      Institute (J.F.G., M.M., R.A.G., T.R.S., A.J.M., K.P.B., J.M.B., C.T.C.), the 
      Schools of Medicine (J.F.G., M.M., A.J.M., K.P.B., C.T.C.), Psychology (J.F.G.), 
      Agriculture, Food, and Wine (R.A.G.), and Public Health (T.R.S.), University of 
      Adelaide, and the Department of Neonatal Medicine, Women's and Children's 
      Hospital (A.J.M.), Adelaide, SA, Newborn Research, Royal Women's Hospital 
      (J.L.Y.C., P.G.D., L.W.D.), the Murdoch Children's Research Institute (P.J.A., 
      J.L.Y.C., P.G.D., L.W.D.), and the Departments of Obstetrics and Gynaecology 
      (J.L.Y.C., P.G.D., L.W.D.) and Paediatrics (L.W.D.), University of Melbourne, the 
      School of Psychological Sciences, Monash University (P.J.A.), and the Department 
      of Paediatrics, Mercy Hospital for Women (G.F.O.), Melbourne, VIC, King Edward 
      Memorial Hospital, Subiaco, WA (M.S.), Newborn Medicine, Centre for Neonatal 
      Research and Education, University of Western Australia, Perth, WA (M.S., K.S.), 
      and the Neonatal Intensive Care Unit, John Hunter Children's Hospital, New 
      Lambton Heights, NSW (J.T.) - all in Australia.
FAU - Anderson, Peter J
AU  - Anderson PJ
AD  - From SAHMRI Women and Kids, South Australian Health and Medical Research 
      Institute (J.F.G., M.M., R.A.G., T.R.S., A.J.M., K.P.B., J.M.B., C.T.C.), the 
      Schools of Medicine (J.F.G., M.M., A.J.M., K.P.B., C.T.C.), Psychology (J.F.G.), 
      Agriculture, Food, and Wine (R.A.G.), and Public Health (T.R.S.), University of 
      Adelaide, and the Department of Neonatal Medicine, Women's and Children's 
      Hospital (A.J.M.), Adelaide, SA, Newborn Research, Royal Women's Hospital 
      (J.L.Y.C., P.G.D., L.W.D.), the Murdoch Children's Research Institute (P.J.A., 
      J.L.Y.C., P.G.D., L.W.D.), and the Departments of Obstetrics and Gynaecology 
      (J.L.Y.C., P.G.D., L.W.D.) and Paediatrics (L.W.D.), University of Melbourne, the 
      School of Psychological Sciences, Monash University (P.J.A.), and the Department 
      of Paediatrics, Mercy Hospital for Women (G.F.O.), Melbourne, VIC, King Edward 
      Memorial Hospital, Subiaco, WA (M.S.), Newborn Medicine, Centre for Neonatal 
      Research and Education, University of Western Australia, Perth, WA (M.S., K.S.), 
      and the Neonatal Intensive Care Unit, John Hunter Children's Hospital, New 
      Lambton Heights, NSW (J.T.) - all in Australia.
FAU - Best, Karen P
AU  - Best KP
AD  - From SAHMRI Women and Kids, South Australian Health and Medical Research 
      Institute (J.F.G., M.M., R.A.G., T.R.S., A.J.M., K.P.B., J.M.B., C.T.C.), the 
      Schools of Medicine (J.F.G., M.M., A.J.M., K.P.B., C.T.C.), Psychology (J.F.G.), 
      Agriculture, Food, and Wine (R.A.G.), and Public Health (T.R.S.), University of 
      Adelaide, and the Department of Neonatal Medicine, Women's and Children's 
      Hospital (A.J.M.), Adelaide, SA, Newborn Research, Royal Women's Hospital 
      (J.L.Y.C., P.G.D., L.W.D.), the Murdoch Children's Research Institute (P.J.A., 
      J.L.Y.C., P.G.D., L.W.D.), and the Departments of Obstetrics and Gynaecology 
      (J.L.Y.C., P.G.D., L.W.D.) and Paediatrics (L.W.D.), University of Melbourne, the 
      School of Psychological Sciences, Monash University (P.J.A.), and the Department 
      of Paediatrics, Mercy Hospital for Women (G.F.O.), Melbourne, VIC, King Edward 
      Memorial Hospital, Subiaco, WA (M.S.), Newborn Medicine, Centre for Neonatal 
      Research and Education, University of Western Australia, Perth, WA (M.S., K.S.), 
      and the Neonatal Intensive Care Unit, John Hunter Children's Hospital, New 
      Lambton Heights, NSW (J.T.) - all in Australia.
FAU - Sharp, Mary
AU  - Sharp M
AD  - From SAHMRI Women and Kids, South Australian Health and Medical Research 
      Institute (J.F.G., M.M., R.A.G., T.R.S., A.J.M., K.P.B., J.M.B., C.T.C.), the 
      Schools of Medicine (J.F.G., M.M., A.J.M., K.P.B., C.T.C.), Psychology (J.F.G.), 
      Agriculture, Food, and Wine (R.A.G.), and Public Health (T.R.S.), University of 
      Adelaide, and the Department of Neonatal Medicine, Women's and Children's 
      Hospital (A.J.M.), Adelaide, SA, Newborn Research, Royal Women's Hospital 
      (J.L.Y.C., P.G.D., L.W.D.), the Murdoch Children's Research Institute (P.J.A., 
      J.L.Y.C., P.G.D., L.W.D.), and the Departments of Obstetrics and Gynaecology 
      (J.L.Y.C., P.G.D., L.W.D.) and Paediatrics (L.W.D.), University of Melbourne, the 
      School of Psychological Sciences, Monash University (P.J.A.), and the Department 
      of Paediatrics, Mercy Hospital for Women (G.F.O.), Melbourne, VIC, King Edward 
      Memorial Hospital, Subiaco, WA (M.S.), Newborn Medicine, Centre for Neonatal 
      Research and Education, University of Western Australia, Perth, WA (M.S., K.S.), 
      and the Neonatal Intensive Care Unit, John Hunter Children's Hospital, New 
      Lambton Heights, NSW (J.T.) - all in Australia.
FAU - Cheong, Jeanie L Y
AU  - Cheong JLY
AD  - From SAHMRI Women and Kids, South Australian Health and Medical Research 
      Institute (J.F.G., M.M., R.A.G., T.R.S., A.J.M., K.P.B., J.M.B., C.T.C.), the 
      Schools of Medicine (J.F.G., M.M., A.J.M., K.P.B., C.T.C.), Psychology (J.F.G.), 
      Agriculture, Food, and Wine (R.A.G.), and Public Health (T.R.S.), University of 
      Adelaide, and the Department of Neonatal Medicine, Women's and Children's 
      Hospital (A.J.M.), Adelaide, SA, Newborn Research, Royal Women's Hospital 
      (J.L.Y.C., P.G.D., L.W.D.), the Murdoch Children's Research Institute (P.J.A., 
      J.L.Y.C., P.G.D., L.W.D.), and the Departments of Obstetrics and Gynaecology 
      (J.L.Y.C., P.G.D., L.W.D.) and Paediatrics (L.W.D.), University of Melbourne, the 
      School of Psychological Sciences, Monash University (P.J.A.), and the Department 
      of Paediatrics, Mercy Hospital for Women (G.F.O.), Melbourne, VIC, King Edward 
      Memorial Hospital, Subiaco, WA (M.S.), Newborn Medicine, Centre for Neonatal 
      Research and Education, University of Western Australia, Perth, WA (M.S., K.S.), 
      and the Neonatal Intensive Care Unit, John Hunter Children's Hospital, New 
      Lambton Heights, NSW (J.T.) - all in Australia.
FAU - Opie, Gillian F
AU  - Opie GF
AD  - From SAHMRI Women and Kids, South Australian Health and Medical Research 
      Institute (J.F.G., M.M., R.A.G., T.R.S., A.J.M., K.P.B., J.M.B., C.T.C.), the 
      Schools of Medicine (J.F.G., M.M., A.J.M., K.P.B., C.T.C.), Psychology (J.F.G.), 
      Agriculture, Food, and Wine (R.A.G.), and Public Health (T.R.S.), University of 
      Adelaide, and the Department of Neonatal Medicine, Women's and Children's 
      Hospital (A.J.M.), Adelaide, SA, Newborn Research, Royal Women's Hospital 
      (J.L.Y.C., P.G.D., L.W.D.), the Murdoch Children's Research Institute (P.J.A., 
      J.L.Y.C., P.G.D., L.W.D.), and the Departments of Obstetrics and Gynaecology 
      (J.L.Y.C., P.G.D., L.W.D.) and Paediatrics (L.W.D.), University of Melbourne, the 
      School of Psychological Sciences, Monash University (P.J.A.), and the Department 
      of Paediatrics, Mercy Hospital for Women (G.F.O.), Melbourne, VIC, King Edward 
      Memorial Hospital, Subiaco, WA (M.S.), Newborn Medicine, Centre for Neonatal 
      Research and Education, University of Western Australia, Perth, WA (M.S., K.S.), 
      and the Neonatal Intensive Care Unit, John Hunter Children's Hospital, New 
      Lambton Heights, NSW (J.T.) - all in Australia.
FAU - Travadi, Javeed
AU  - Travadi J
AD  - From SAHMRI Women and Kids, South Australian Health and Medical Research 
      Institute (J.F.G., M.M., R.A.G., T.R.S., A.J.M., K.P.B., J.M.B., C.T.C.), the 
      Schools of Medicine (J.F.G., M.M., A.J.M., K.P.B., C.T.C.), Psychology (J.F.G.), 
      Agriculture, Food, and Wine (R.A.G.), and Public Health (T.R.S.), University of 
      Adelaide, and the Department of Neonatal Medicine, Women's and Children's 
      Hospital (A.J.M.), Adelaide, SA, Newborn Research, Royal Women's Hospital 
      (J.L.Y.C., P.G.D., L.W.D.), the Murdoch Children's Research Institute (P.J.A., 
      J.L.Y.C., P.G.D., L.W.D.), and the Departments of Obstetrics and Gynaecology 
      (J.L.Y.C., P.G.D., L.W.D.) and Paediatrics (L.W.D.), University of Melbourne, the 
      School of Psychological Sciences, Monash University (P.J.A.), and the Department 
      of Paediatrics, Mercy Hospital for Women (G.F.O.), Melbourne, VIC, King Edward 
      Memorial Hospital, Subiaco, WA (M.S.), Newborn Medicine, Centre for Neonatal 
      Research and Education, University of Western Australia, Perth, WA (M.S., K.S.), 
      and the Neonatal Intensive Care Unit, John Hunter Children's Hospital, New 
      Lambton Heights, NSW (J.T.) - all in Australia.
FAU - Bednarz, Jana M
AU  - Bednarz JM
AD  - From SAHMRI Women and Kids, South Australian Health and Medical Research 
      Institute (J.F.G., M.M., R.A.G., T.R.S., A.J.M., K.P.B., J.M.B., C.T.C.), the 
      Schools of Medicine (J.F.G., M.M., A.J.M., K.P.B., C.T.C.), Psychology (J.F.G.), 
      Agriculture, Food, and Wine (R.A.G.), and Public Health (T.R.S.), University of 
      Adelaide, and the Department of Neonatal Medicine, Women's and Children's 
      Hospital (A.J.M.), Adelaide, SA, Newborn Research, Royal Women's Hospital 
      (J.L.Y.C., P.G.D., L.W.D.), the Murdoch Children's Research Institute (P.J.A., 
      J.L.Y.C., P.G.D., L.W.D.), and the Departments of Obstetrics and Gynaecology 
      (J.L.Y.C., P.G.D., L.W.D.) and Paediatrics (L.W.D.), University of Melbourne, the 
      School of Psychological Sciences, Monash University (P.J.A.), and the Department 
      of Paediatrics, Mercy Hospital for Women (G.F.O.), Melbourne, VIC, King Edward 
      Memorial Hospital, Subiaco, WA (M.S.), Newborn Medicine, Centre for Neonatal 
      Research and Education, University of Western Australia, Perth, WA (M.S., K.S.), 
      and the Neonatal Intensive Care Unit, John Hunter Children's Hospital, New 
      Lambton Heights, NSW (J.T.) - all in Australia.
FAU - Davis, Peter G
AU  - Davis PG
AD  - From SAHMRI Women and Kids, South Australian Health and Medical Research 
      Institute (J.F.G., M.M., R.A.G., T.R.S., A.J.M., K.P.B., J.M.B., C.T.C.), the 
      Schools of Medicine (J.F.G., M.M., A.J.M., K.P.B., C.T.C.), Psychology (J.F.G.), 
      Agriculture, Food, and Wine (R.A.G.), and Public Health (T.R.S.), University of 
      Adelaide, and the Department of Neonatal Medicine, Women's and Children's 
      Hospital (A.J.M.), Adelaide, SA, Newborn Research, Royal Women's Hospital 
      (J.L.Y.C., P.G.D., L.W.D.), the Murdoch Children's Research Institute (P.J.A., 
      J.L.Y.C., P.G.D., L.W.D.), and the Departments of Obstetrics and Gynaecology 
      (J.L.Y.C., P.G.D., L.W.D.) and Paediatrics (L.W.D.), University of Melbourne, the 
      School of Psychological Sciences, Monash University (P.J.A.), and the Department 
      of Paediatrics, Mercy Hospital for Women (G.F.O.), Melbourne, VIC, King Edward 
      Memorial Hospital, Subiaco, WA (M.S.), Newborn Medicine, Centre for Neonatal 
      Research and Education, University of Western Australia, Perth, WA (M.S., K.S.), 
      and the Neonatal Intensive Care Unit, John Hunter Children's Hospital, New 
      Lambton Heights, NSW (J.T.) - all in Australia.
FAU - Simmer, Karen
AU  - Simmer K
AD  - From SAHMRI Women and Kids, South Australian Health and Medical Research 
      Institute (J.F.G., M.M., R.A.G., T.R.S., A.J.M., K.P.B., J.M.B., C.T.C.), the 
      Schools of Medicine (J.F.G., M.M., A.J.M., K.P.B., C.T.C.), Psychology (J.F.G.), 
      Agriculture, Food, and Wine (R.A.G.), and Public Health (T.R.S.), University of 
      Adelaide, and the Department of Neonatal Medicine, Women's and Children's 
      Hospital (A.J.M.), Adelaide, SA, Newborn Research, Royal Women's Hospital 
      (J.L.Y.C., P.G.D., L.W.D.), the Murdoch Children's Research Institute (P.J.A., 
      J.L.Y.C., P.G.D., L.W.D.), and the Departments of Obstetrics and Gynaecology 
      (J.L.Y.C., P.G.D., L.W.D.) and Paediatrics (L.W.D.), University of Melbourne, the 
      School of Psychological Sciences, Monash University (P.J.A.), and the Department 
      of Paediatrics, Mercy Hospital for Women (G.F.O.), Melbourne, VIC, King Edward 
      Memorial Hospital, Subiaco, WA (M.S.), Newborn Medicine, Centre for Neonatal 
      Research and Education, University of Western Australia, Perth, WA (M.S., K.S.), 
      and the Neonatal Intensive Care Unit, John Hunter Children's Hospital, New 
      Lambton Heights, NSW (J.T.) - all in Australia.
FAU - Doyle, Lex W
AU  - Doyle LW
AUID- ORCID: 0000-0002-7667-7312
AD  - From SAHMRI Women and Kids, South Australian Health and Medical Research 
      Institute (J.F.G., M.M., R.A.G., T.R.S., A.J.M., K.P.B., J.M.B., C.T.C.), the 
      Schools of Medicine (J.F.G., M.M., A.J.M., K.P.B., C.T.C.), Psychology (J.F.G.), 
      Agriculture, Food, and Wine (R.A.G.), and Public Health (T.R.S.), University of 
      Adelaide, and the Department of Neonatal Medicine, Women's and Children's 
      Hospital (A.J.M.), Adelaide, SA, Newborn Research, Royal Women's Hospital 
      (J.L.Y.C., P.G.D., L.W.D.), the Murdoch Children's Research Institute (P.J.A., 
      J.L.Y.C., P.G.D., L.W.D.), and the Departments of Obstetrics and Gynaecology 
      (J.L.Y.C., P.G.D., L.W.D.) and Paediatrics (L.W.D.), University of Melbourne, the 
      School of Psychological Sciences, Monash University (P.J.A.), and the Department 
      of Paediatrics, Mercy Hospital for Women (G.F.O.), Melbourne, VIC, King Edward 
      Memorial Hospital, Subiaco, WA (M.S.), Newborn Medicine, Centre for Neonatal 
      Research and Education, University of Western Australia, Perth, WA (M.S., K.S.), 
      and the Neonatal Intensive Care Unit, John Hunter Children's Hospital, New 
      Lambton Heights, NSW (J.T.) - all in Australia.
FAU - Collins, Carmel T
AU  - Collins CT
AUID- ORCID: 0000-0003-3308-9948
AD  - From SAHMRI Women and Kids, South Australian Health and Medical Research 
      Institute (J.F.G., M.M., R.A.G., T.R.S., A.J.M., K.P.B., J.M.B., C.T.C.), the 
      Schools of Medicine (J.F.G., M.M., A.J.M., K.P.B., C.T.C.), Psychology (J.F.G.), 
      Agriculture, Food, and Wine (R.A.G.), and Public Health (T.R.S.), University of 
      Adelaide, and the Department of Neonatal Medicine, Women's and Children's 
      Hospital (A.J.M.), Adelaide, SA, Newborn Research, Royal Women's Hospital 
      (J.L.Y.C., P.G.D., L.W.D.), the Murdoch Children's Research Institute (P.J.A., 
      J.L.Y.C., P.G.D., L.W.D.), and the Departments of Obstetrics and Gynaecology 
      (J.L.Y.C., P.G.D., L.W.D.) and Paediatrics (L.W.D.), University of Melbourne, the 
      School of Psychological Sciences, Monash University (P.J.A.), and the Department 
      of Paediatrics, Mercy Hospital for Women (G.F.O.), Melbourne, VIC, King Edward 
      Memorial Hospital, Subiaco, WA (M.S.), Newborn Medicine, Centre for Neonatal 
      Research and Education, University of Western Australia, Perth, WA (M.S., K.S.), 
      and the Neonatal Intensive Care Unit, John Hunter Children's Hospital, New 
      Lambton Heights, NSW (J.T.) - all in Australia.
LA  - eng
SI  - ANZCTR/ACTRN12612000503820
GR  - 1022112/National Health and Medical Research Council/
GR  - 1146806/National Health and Medical Research Council/
GR  - Centre for Research Excellence GNT1135155/National Health and Medical Research 
      Council/
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - 0 (Emulsions)
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Australia
MH  - *Bronchopulmonary Dysplasia/prevention & control
MH  - Dietary Supplements/adverse effects
MH  - *Docosahexaenoic Acids/deficiency/pharmacology/therapeutic use
MH  - Emulsions
MH  - Follow-Up Studies
MH  - *Infant, Premature/growth & development
MH  - *Intelligence/drug effects
MH  - Enteral Nutrition
MH  - Wechsler Scales
MH  - *Cognition/drug effects
EDAT- 2022/10/28 06:00
MHDA- 2022/11/01 06:00
CRDT- 2022/10/27 09:22
PHST- 2022/10/27 09:22 [entrez]
PHST- 2022/10/28 06:00 [pubmed]
PHST- 2022/11/01 06:00 [medline]
AID - 10.1056/NEJMoa2206868 [doi]
PST - ppublish
SO  - N Engl J Med. 2022 Oct 27;387(17):1579-1588. doi: 10.1056/NEJMoa2206868.