PMID- 36301106 OWN - NLM STAT- MEDLINE DCOM- 20221118 LR - 20230103 IS - 1520-5851 (Electronic) IS - 0013-936X (Linking) VI - 56 IP - 22 DP - 2022 Nov 15 TI - Infant Exposure to PCBs and PBDEs Revealed by Hair and Human Milk Analysis: Evaluation of Hair as an Alternative Biomatrix. PG - 15912-15919 LID - 10.1021/acs.est.2c04045 [doi] AB - Human hair, as an emerging biological monitoring matrix, has begun to be used in various human exposure studies, but little research has been done on persistent organic pollutants (POPs), especially for the body burden of POPs in infants. In this study, 36 breast-fed infants in Shanghai were recruited for a study to determine their exposure to POPs, including 12 dioxin-like polychlorinated biphenyls (dl-PCBs), 6 indicator PCBs, and 8 polybrominated diphenyl ethers (PBDEs) in the inner layer (internal) and outer layer (external) of infant hair and human milk. The similarity or difference of the POP distribution pattern or concentration among these matrices was investigated, and only weak correlations (r < 0.4) were observed between the POP concentration in human milk and infant hair (internal or external). POPs in human milk have a different profile than those in infant hair, while they have stable concentration ratios (0.58-2.72), similar distribution patterns, fine Spearman's rank correlations, and tangled principal component analysis (PCA) plots in each POP family between external and internal hair samples. The result suggested that POPs in internal hair can be easily affected by those in external hair, but POPs in human milk seem to have little contribution to the POP profile in internal hair. Although infant hair cannot reflect the POPs from diet or from body burden, it can be an ideal biomatrix that estimates infant exposure to POPs from exogenous sources like house dust when considering the similar pattern of POPs and their proper accumulation period in hair. FAU - Lin, Yuanjie AU - Lin Y AUID- ORCID: 0000-0003-3572-5581 AD - Shanghai Municipal Center for Disease Control and Prevention/State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, 1380 West Zhongshan Road, Shanghai 200336, China. FAU - Feng, Chao AU - Feng C AUID- ORCID: 0000-0002-9690-6661 AD - Shanghai Municipal Center for Disease Control and Prevention/State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, 1380 West Zhongshan Road, Shanghai 200336, China. FAU - Le, Sunyang AU - Le S AD - Shanghai Municipal Center for Disease Control and Prevention/State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, 1380 West Zhongshan Road, Shanghai 200336, China. FAU - Qiu, Xinlei AU - Qiu X AD - Shanghai Municipal Center for Disease Control and Prevention/State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, 1380 West Zhongshan Road, Shanghai 200336, China. FAU - Xu, Qian AU - Xu Q AD - Shanghai Municipal Center for Disease Control and Prevention/State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, 1380 West Zhongshan Road, Shanghai 200336, China. FAU - Jin, Shuping AU - Jin S AD - Shanghai Municipal Center for Disease Control and Prevention/State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, 1380 West Zhongshan Road, Shanghai 200336, China. FAU - Fang, Yamin AU - Fang Y AD - Shanghai Municipal Center for Disease Control and Prevention/State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, 1380 West Zhongshan Road, Shanghai 200336, China. FAU - Jin, Yu'e AU - Jin Y AD - Shanghai Municipal Center for Disease Control and Prevention/State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, 1380 West Zhongshan Road, Shanghai 200336, China. FAU - Wen, Yimin AU - Wen Y AD - Shanghai Municipal Center for Disease Control and Prevention/State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, 1380 West Zhongshan Road, Shanghai 200336, China. FAU - Wang, Guoquan AU - Wang G AD - Shanghai Municipal Center for Disease Control and Prevention/State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, 1380 West Zhongshan Road, Shanghai 200336, China. FAU - Lu, Dasheng AU - Lu D AD - Shanghai Municipal Center for Disease Control and Prevention/State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, 1380 West Zhongshan Road, Shanghai 200336, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20221027 PL - United States TA - Environ Sci Technol JT - Environmental science & technology JID - 0213155 RN - DFC2HB4I0K (Polychlorinated Biphenyls) RN - 0 (Halogenated Diphenyl Ethers) RN - 0 (Environmental Pollutants) SB - IM MH - Infant MH - Humans MH - *Polychlorinated Biphenyls/analysis MH - Halogenated Diphenyl Ethers/analysis MH - Milk, Human/chemistry MH - Environmental Monitoring MH - China MH - *Environmental Pollutants/analysis MH - Hair/chemistry OTO - NOTNLM OT - PBDEs OT - PCBs OT - human biomonitoring OT - human milk OT - infant hair EDAT- 2022/10/28 06:00 MHDA- 2022/11/19 06:00 CRDT- 2022/10/27 10:15 PHST- 2022/10/28 06:00 [pubmed] PHST- 2022/11/19 06:00 [medline] PHST- 2022/10/27 10:15 [entrez] AID - 10.1021/acs.est.2c04045 [doi] PST - ppublish SO - Environ Sci Technol. 2022 Nov 15;56(22):15912-15919. doi: 10.1021/acs.est.2c04045. Epub 2022 Oct 27.