PMID- 36301873
OWN - NLM
STAT- MEDLINE
DCOM- 20221031
LR  - 20221031
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 17
IP  - 10
DP  - 2022
TI  - Comparison of arterial and venous allograft bypass in chronic limb-threatening 
      ischemia.
PG  - e0275628
LID - 10.1371/journal.pone.0275628 [doi]
LID - e0275628
AB  - INTRODUCTION: Femoro-popliteal bypass with autologous vascular graft is a key 
      revascularization method in chronic limb-threatening ischemia (CLTI). However, 
      the lack of suitable autologous conduit may occur in 15-45% of the patients, 
      necessitating the implantation of prosthetic or allogen grafts. Only little data 
      is available on the outcome of allograft use in CLTI. AIMS: Our objective were to 
      evaluate the long term results of infrainguinal allograft bypass surgery in 
      patients with chronic limb-threatening ischemia (CLTI) and compare the results of 
      arterial and venous allografts. METHODS: Single center, retrospective study 
      analysing the outcomes of infrainguinal allograft bypass surgery in patients with 
      CLTI between January 2007 and December 2017. RESULTS: During a 11-year period, 
      134 infrainguinal allograft bypasses were performed for CLTI [91 males (67.9%)]. 
      Great saphenous vein (GSV) was implanted in 100 cases, superficial femoral artery 
      (SFA) was implanted in 34 cases. Early postoperative complications appeared in 
      16.4% of cases and perioperative mortality (<30 days) was 1.4%. Primary patency 
      at one, three and five years was 59%, 44% and 41%, respectively, while secondary 
      patency was 60%, 45% and 41%, respectively. Primary patency of the SFA allografts 
      was significantly higher than GSV allografts (1 year: SFA: 84% vs. GSV: 51% p = 
      0,001; 3 years: SFA: 76% vs. GSV: 32% p = 0,001; 5 years: SFA: 71% vs. GSV: 30% p 
      = 0.001). Both primary and secondary patency of SFA allograft implanted in 
      below-knee position were significantly higher than GSV bypasses (p = 0.0006; p = 
      0.0005, respectively). Limb salvage at one, three and five years following 
      surgery was 74%, 64% and 62%, respectively. Long-term survival was 53% at 5 
      years. CONCLUSION: Allograft implantation is a suitable method for limb salvage 
      in CLTI. The patency of arterial allograft is better than venous allograft 
      patency, especially in below-knee position during infrainguinal allograft bypass 
      surgery.
FAU - Garbaisz, David
AU  - Garbaisz D
AD  - Department of Vascular and Endovascular Surgery, Heart and Vascular Center, 
      Semmelweis University, Budapest, Hungary.
FAU - Osztrogonacz, Peter
AU  - Osztrogonacz P
AD  - Department of Vascular and Endovascular Surgery, Heart and Vascular Center, 
      Semmelweis University, Budapest, Hungary.
FAU - Boros, Andras Mihaly
AU  - Boros AM
AD  - Department of Cardiology, Heart and Vascular Center, Semmelweis University, 
      Budapest, Hungary.
FAU - Hidi, Laszlo
AU  - Hidi L
AUID- ORCID: 0000-0003-4128-0523
AD  - Department of Vascular and Endovascular Surgery, Heart and Vascular Center, 
      Semmelweis University, Budapest, Hungary.
FAU - Sotonyi, Peter
AU  - Sotonyi P
AUID- ORCID: 0000-0002-2216-4298
AD  - Department of Vascular and Endovascular Surgery, Heart and Vascular Center, 
      Semmelweis University, Budapest, Hungary.
FAU - Szeberin, Zoltan
AU  - Szeberin Z
AD  - Department of Vascular and Endovascular Surgery, Heart and Vascular Center, 
      Semmelweis University, Budapest, Hungary.
LA  - eng
PT  - Journal Article
DEP - 20221027
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Male
MH  - Humans
MH  - *Ischemia
MH  - Vascular Patency
MH  - Chronic Limb-Threatening Ischemia
MH  - Retrospective Studies
MH  - Saphenous Vein/surgery
MH  - Limb Salvage
MH  - Allografts
MH  - Treatment Outcome
MH  - *Peripheral Arterial Disease
MH  - Risk Factors
PMC - PMC9612501
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/10/28 06:00
MHDA- 2022/11/01 06:00
PMCR- 2022/10/27
CRDT- 2022/10/27 13:43
PHST- 2022/02/14 00:00 [received]
PHST- 2022/09/20 00:00 [accepted]
PHST- 2022/10/27 13:43 [entrez]
PHST- 2022/10/28 06:00 [pubmed]
PHST- 2022/11/01 06:00 [medline]
PHST- 2022/10/27 00:00 [pmc-release]
AID - PONE-D-22-04564 [pii]
AID - 10.1371/journal.pone.0275628 [doi]
PST - epublish
SO  - PLoS One. 2022 Oct 27;17(10):e0275628. doi: 10.1371/journal.pone.0275628. 
      eCollection 2022.