PMID- 36304525
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221029
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 10
DP  - 2022
TI  - Long-term safety and efficacy of fecal microbiota transplantation in 74 children: 
      A single-center retrospective study.
PG  - 964154
LID - 10.3389/fped.2022.964154 [doi]
LID - 964154
AB  - BACKGROUND: Fecal microbiota transplantation (FMT) is an effective treatment for 
      intestinal and extra-intestinal disorders. Nonetheless, long-term safety and 
      efficacy remain major challenges for FMT applications. To date, few long-term 
      follow-up studies have been published on FMT in children. METHODS: Retrospective 
      reviewed the medical charts of 74 patients who underwent 508 FMT courses between 
      August 2014 and July 2019 at our medical center. All the FMT procedures followed 
      uniform standards. Baseline characteristics pre-FMT and follow-up data were 
      collected at 1, 3, 6, 12, 36, 60, and 84 months after FMT. All potential 
      influencing factors for adverse events (AEs) were analyzed and assessed using 
      regression analyses. RESULTS: A total of 70 (13.7%) short-term AEs occurred in 
      twenty-six patients (35.1%). Most AEs (88.5%) occurred within 2 days post-FMT. A 
      total of 91.4% of the AEs were self-limiting. Ulcerative colitis (UC) and within 
      four times of FMT were associated with a higher rate of AEs (p = 0.028 and p = 
      0.021, respectively). The primary clinical remission rate after FMT was as high 
      as 72.9%. Twenty-five children were followed for more than 5 years after FMT. The 
      clinical remission rates gradually decreased over time after FMT. During 
      follow-up, none of the patients developed autoimmune, metabolic, or rheumatologic 
      disorders or tumor-related diseases. However, nine children developed rhinitis, 
      five developed rhinitis, were underweight, and six developed constipation. 
      CONCLUSIONS: FMT is a safe and effective treatment for dysbiosis in children. The 
      long-term efficacy of FMT for each disease decreased over time. Moreover, 
      multiple FMTs are recommended 3 months post-FMT for recurrent diseases.
CI  - Copyright (c) 2022 Zou, Liu, Li, He, Dong, Ruan, Xu, Bai, Huang and Shu.
FAU - Zou, Biao
AU  - Zou B
AD  - Pediatric Department, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Liu, Sheng-Xuan
AU  - Liu SX
AD  - Pediatric Department, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Li, Xue-Song
AU  - Li XS
AD  - Pediatric Department, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - He, Jia-Yi
AU  - He JY
AD  - Pediatric Department, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Dong, Chen
AU  - Dong C
AD  - Pediatric Department, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Ruan, Meng-Ling
AU  - Ruan ML
AD  - Pediatric Department, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Xu, Lei
AU  - Xu L
AD  - Pediatric Department, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Bai, Tao
AU  - Bai T
AD  - Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Huang, Zhi-Hua
AU  - Huang ZH
AD  - Pediatric Department, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Shu, Sai-Nan
AU  - Shu SN
AD  - Pediatric Department, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
LA  - eng
PT  - Journal Article
DEP - 20221011
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC9595213
OTO - NOTNLM
OT  - adverse event
OT  - children
OT  - efficacy
OT  - fecal microbiota transplantation
OT  - follow-up
OT  - safety
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest. The handling editor YL is currently organizing a Research 
      Topic with the author S-NS.
EDAT- 2022/10/29 06:00
MHDA- 2022/10/29 06:01
PMCR- 2022/10/11
CRDT- 2022/10/28 02:52
PHST- 2022/06/08 00:00 [received]
PHST- 2022/08/18 00:00 [accepted]
PHST- 2022/10/28 02:52 [entrez]
PHST- 2022/10/29 06:00 [pubmed]
PHST- 2022/10/29 06:01 [medline]
PHST- 2022/10/11 00:00 [pmc-release]
AID - 10.3389/fped.2022.964154 [doi]
PST - epublish
SO  - Front Pediatr. 2022 Oct 11;10:964154. doi: 10.3389/fped.2022.964154. eCollection 
      2022.