PMID- 36305577
OWN - NLM
STAT- MEDLINE
DCOM- 20230207
LR  - 20240202
IS  - 1550-9397 (Electronic)
IS  - 1550-9389 (Print)
IS  - 1550-9389 (Linking)
VI  - 19
IP  - 2
DP  - 2023 Feb 1
TI  - Clinical and neurophysiological characteristics of 89 patients with narcolepsy 
      and cataplexy from the Russian Narcolepsy Network.
PG  - 355-359
LID - 10.5664/jcsm.10340 [doi]
AB  - STUDY OBJECTIVES: The first reports of narcolepsy with cataplexy in Russia were 
      made by Mankovsky (The pathogenesis of narcolepsy (the case of epidemic 
      encephalitis with cataplexy) published in the Sovremennaya psihonevrologia) in 
      1925. The largest series of patients (n = 110) was reported by A. Vein (doctoral 
      thesis: Hypersomnia Syndrome) in 1964. However, until today, narcolepsy remained 
      relatively unknown in Russia. The aim of this study is to report clinical and 
      polysomnography (PSG)/multiple sleep latency test (MSLT) results in the Russian 
      population and compare them with the European Narcolepsy Network (EU-NN) data (n 
      = 1099) reported. METHODS: Eleven sleep centers from Russia agreed to participate 
      and completed a questionnaire including 58 questions concerning demographic, 
      clinical, PSG, and MSLT data. RESULTS: There were 89 patients with a mean age of 
      35.6 +/- 16.9 years (+/- here and further indicates standard deviation), 58% males, 
      and 42% females. Narcolepsy started at a mean age of 25.6 +/- 14.6 years (range 
      5-74 years). The mean Epworth Sleepiness Scale score was 18.4 +/- 3.5 points 
      (range: 11-24). Sleep paralysis was reported by 59.1%, and hallucinations by 82% 
      of patients. In MSLT, >/= 2 sleep-onset REM (rapid eye movement) periods (SOREMPs) 
      were found in 81.6%. No center provided human leukocyte antigen (HLA) or cerebral 
      spinal fluid hypocretin data. CONCLUSIONS: Clinical and neurophysiological data 
      from this first study of the Russian Narcolepsy Network suggest a similar profile 
      to the recently reported EU-NN data. The more severe and higher percentage of 
      patients with cataplexy and presenting with both excessive daytime sleepiness and 
      cataplexy may reflect low awareness of narcolepsy in Russia. CLINICAL TRIAL 
      REGISTRATION: Registry: ClinicalTrials.gov; URL: 
      https://clinicaltrials.gov/ct2/show/NCT05375890; Name: Clinical and 
      Neurophysiological Characteristics of Narcolepsy; Identifier: NCT05375890. 
      CITATION: Kuts A, Poluektov M, Zakharov A, et al. Clinical and neurophysiological 
      characteristics of 89 patients with narcolepsy and cataplexy from the Russian 
      Narcolepsy Network. J Clin Sleep Med. 2023;19(2):355-359.
CI  - (c) 2023 American Academy of Sleep Medicine.
FAU - Kuts, Alexander
AU  - Kuts A
AD  - Sechenov University, Moscow, Russia.
FAU - Poluektov, Michael
AU  - Poluektov M
AD  - Sechenov University, Moscow, Russia.
FAU - Zakharov, Alexander
AU  - Zakharov A
AD  - Department of Neurology and Neurosurgery, Samara State Medical University, 
      Samara, Russia.
AD  - Samara State Medical University, Research Institute of Neurosciences, Samara, 
      Russia.
FAU - Govzman, Vlada
AU  - Govzman V
AD  - Clinical Hospital "RZD-Medicine", Khabarovsk, Russia.
FAU - Ponomareva, Irina
AU  - Ponomareva I
AD  - Regional Clinical Hospital No. 3, Chelyabinsk, Russia.
FAU - Yakupov, Eduard
AU  - Yakupov E
AD  - Kazan State Medical University, Kazan, Russia.
FAU - Zavalko, Irina
AU  - Zavalko I
AD  - Research Center of Neurology, Moscow, Russia.
FAU - Tikhomirova, Olga
AU  - Tikhomirova O
AD  - Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia, 
      Saint-Petersburg, Russia.
FAU - Sviryaev, Yurii
AU  - Sviryaev Y
AD  - Almazov National Medical Research Centre, Saint-Petersburg, Russia.
FAU - Yakovlev, Alexey
AU  - Yakovlev A
AD  - Novosibirsk State Medical University, Novosibirsk, Russia.
FAU - Polyakov, Alexander
AU  - Polyakov A
AD  - V.M. Bekhterev National Research Medical Center for Psychiatry and Neurology, 
      Saint-Petersburg, Russia.
FAU - Melnikov, Alexander
AU  - Melnikov A
AD  - FSBI NMRCO FMBA Russia, Moscow, Russia.
FAU - Bassetti, Claudio L A
AU  - Bassetti CLA
AD  - Sechenov University, Moscow, Russia.
AD  - University Hospital (Inselspital), Bern, Switzerland.
LA  - eng
SI  - ClinicalTrials.gov/NCT05375890
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - J Clin Sleep Med
JT  - Journal of clinical sleep medicine : JCSM : official publication of the American 
      Academy of Sleep Medicine
JID - 101231977
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Young Adult
MH  - *Cataplexy/complications
MH  - *Disorders of Excessive Somnolence
MH  - *Narcolepsy/complications/diagnosis
MH  - Sleep
MH  - Sleep, REM/physiology
PMC - PMC9892735
OTO - NOTNLM
OT  - MSLT
OT  - PSG
OT  - Russia
OT  - cataplexy
OT  - excessive daytime sleepiness
OT  - narcolepsy
COIS- All authors have seen and approved the manuscript. Work for this study was 
      performed at Sechenov University, Moscow. The authors report no conflicts of 
      interest.
EDAT- 2022/10/29 06:00
MHDA- 2023/02/04 06:00
PMCR- 2024/02/01
CRDT- 2022/10/28 07:52
PHST- 2022/10/29 06:00 [pubmed]
PHST- 2023/02/04 06:00 [medline]
PHST- 2022/10/28 07:52 [entrez]
PHST- 2024/02/01 00:00 [pmc-release]
AID - jcsm.10340 [pii]
AID - JC2200260 [pii]
AID - 10.5664/jcsm.10340 [doi]
PST - ppublish
SO  - J Clin Sleep Med. 2023 Feb 1;19(2):355-359. doi: 10.5664/jcsm.10340.