PMID- 36305777
OWN - NLM
STAT- MEDLINE
DCOM- 20230515
LR  - 20230515
IS  - 2724-5772 (Electronic)
IS  - 2724-5683 (Linking)
VI  - 71
IP  - 3
DP  - 2023 Jun
TI  - Cryoablation of para-Hisian and mid-septal accessory pathways: long-term outcomes 
      of a specific stepwise cryoablation protocol.
PG  - 333-341
LID - 10.23736/S2724-5683.22.06136-1 [doi]
AB  - BACKGROUND: Although cryoablation (CA) of septally located accessory pathways 
      (APs) is an established treatment for Wolff-Parkinson-White Syndrome, its major 
      limitation is the lack of data regarding long-term follow-up (FU). The present 
      study sought to investigate long-term outcomes of a specific CA protocol 
      targeting para-Hisian (P-H) and mid-septal (M-S) APs. METHODS: Twenty-six 
      patients who previously underwent CA of PH or MS APs from 2004 to 2014, were 
      prospectively considered to receive a FU during 2021. All subjects received an 
      outpatient control visit, performing an exercise stress test and a 24-h ECG 
      Holter monitoring. RESULTS: Acute success was achieved in 22 patients (85%). One 
      case of recurrence was reported at short-term FU. Long-term FU, performed after a 
      mean time of 150+/-37 months, did not show ventricular preexcitation recurrences, 
      with a success rate of 81%, and without late adverse events. Symptoms reduction 
      (12% vs. 96%, P<.001) and lower rates of antiarrhythmic drug use (12% vs. 62%, 
      P<.001) were observed at long term-FU with respect to baseline. This clinical 
      outcome was detected also among patients who underwent unsuccessful CA at 
      baseline. CONCLUSIONS: Our CA protocol confirmed remarkable safety and efficacy 
      throughout a long-term FU. Significant clinical improvement in terms of 
      antiarrhythmic therapy discontinuation and symptoms reduction was also shown 
      among patients who experienced acute failure of CA.
FAU - Mitacchione, Gianfranco
AU  - Mitacchione G
AD  - Department of Heart and Vessels, Ospedale di Circolo e Fondazione Macchi, 
      University of Insubria, Varese, Italy - gianfrancomit@hotmail.com.
FAU - Marazzi, Raffaella
AU  - Marazzi R
AD  - Department of Heart and Vessels, Ospedale di Circolo e Fondazione Macchi, 
      University of Insubria, Varese, Italy.
FAU - Doni, Lorenzo
AU  - Doni L
AD  - Department of Heart and Vessels, Ospedale di Circolo e Fondazione Macchi, 
      University of Insubria, Varese, Italy.
FAU - Marazzato, Jacopo
AU  - Marazzato J
AD  - Department of Heart and Vessels, Ospedale di Circolo e Fondazione Macchi, 
      University of Insubria, Varese, Italy.
FAU - DE Ponti, Roberto
AU  - DE Ponti R
AD  - Department of Heart and Vessels, Ospedale di Circolo e Fondazione Macchi, 
      University of Insubria, Varese, Italy.
LA  - eng
PT  - Journal Article
DEP - 20221028
PL  - Italy
TA  - Minerva Cardiol Angiol
JT  - Minerva cardiology and angiology
JID - 101776555
RN  - 0 (Anti-Arrhythmia Agents)
SB  - IM
MH  - Humans
MH  - *Cryosurgery/adverse effects/methods
MH  - Treatment Outcome
MH  - *Accessory Atrioventricular Bundle/surgery/etiology
MH  - *Wolff-Parkinson-White Syndrome/surgery/etiology
MH  - Anti-Arrhythmia Agents
EDAT- 2022/10/29 06:00
MHDA- 2023/05/15 06:42
CRDT- 2022/10/28 10:30
PHST- 2023/05/15 06:42 [medline]
PHST- 2022/10/29 06:00 [pubmed]
PHST- 2022/10/28 10:30 [entrez]
AID - S2724-5683.22.06136-1 [pii]
AID - 10.23736/S2724-5683.22.06136-1 [doi]
PST - ppublish
SO  - Minerva Cardiol Angiol. 2023 Jun;71(3):333-341. doi: 
      10.23736/S2724-5683.22.06136-1. Epub 2022 Oct 28.