PMID- 36305946 OWN - NLM STAT- MEDLINE DCOM- 20230202 LR - 20230506 IS - 1432-1335 (Electronic) IS - 0171-5216 (Linking) VI - 149 IP - 1 DP - 2023 Jan TI - Long non-coding RNAs involved in retinoblastoma. PG - 401-421 LID - 10.1007/s00432-022-04398-z [doi] AB - INTRODUCTION: Retinoblastoma (RB) is the most common childhood tumor that can occur in the retina and develop in a sporadic or heritable form. Although various traditional treatment options have been used for patients with RB, identifying novel strategies for childhood cancers is necessary. MATERIAL AND METHODS: Recently, molecular-based targeted therapies have opened a greater therapeutic window for RB. Long non-coding RNAs (lncRNAs) presented a potential role as a biomarker for the detection of RB in various stages. CONCLUSION: LncRNAs by targeting several miRNA/transcription factors play critical roles in the stimulation or suppression of RB. In this review, we summarized recent progress on the functions of tumor suppressors or oncogenes lncRNAs in RB. CI - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Nasrolahi, Ava AU - Nasrolahi A AD - Infectious Ophthalmologic Research Center, Imam Khomeini Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. FAU - Azizidoost, Shirin AU - Azizidoost S AD - Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. FAU - Radoszkiewicz, Klaudia AU - Radoszkiewicz K AD - Translational Platform for Regenerative Medicine, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland. FAU - Najafi, Sajad AU - Najafi S AD - Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Ghaedrahmati, Farhoodeh AU - Ghaedrahmati F AD - Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Sheykhi-Sabzehpoush, Mohadeseh AU - Sheykhi-Sabzehpoush M AD - Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. FAU - Poodineh, Jafar AU - Poodineh J AD - Department of Clinical Biochemistry, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran. FAU - Hajizadeh, Maryam AU - Hajizadeh M AD - Infectious Ophthalmologic Research Center, Imam Khomeini Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. AD - Department of Ophthalmology, Imam Khomeini Hospital, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. FAU - Anbiyaiee, Amir AU - Anbiyaiee A AD - Department of Surgery, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. FAU - Farzaneh, Maryam AU - Farzaneh M AD - Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. farzaneh-m@ajums.ac.ir. FAU - Feghhi, Mostafa AU - Feghhi M AD - Infectious Ophthalmologic Research Center, Imam Khomeini Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. mfeghhi@ajums.ac.ir. AD - Department of Ophthalmology, Imam Khomeini Hospital, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. mfeghhi@ajums.ac.ir. LA - eng PT - Journal Article PT - Review DEP - 20221028 PL - Germany TA - J Cancer Res Clin Oncol JT - Journal of cancer research and clinical oncology JID - 7902060 RN - 0 (RNA, Long Noncoding) RN - 0 (MicroRNAs) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Child MH - *Retinoblastoma/genetics/pathology MH - *RNA, Long Noncoding/genetics MH - *MicroRNAs/genetics MH - Biomarkers MH - *Retinal Neoplasms/genetics/pathology OTO - NOTNLM OT - Biomarker OT - Long non-coding RNA OT - Oncogene OT - Retinoblastoma OT - Tumor suppressor EDAT- 2022/10/29 06:00 MHDA- 2023/02/03 06:00 CRDT- 2022/10/28 11:24 PHST- 2022/09/12 00:00 [received] PHST- 2022/10/05 00:00 [accepted] PHST- 2022/10/29 06:00 [pubmed] PHST- 2023/02/03 06:00 [medline] PHST- 2022/10/28 11:24 [entrez] AID - 10.1007/s00432-022-04398-z [pii] AID - 10.1007/s00432-022-04398-z [doi] PST - ppublish SO - J Cancer Res Clin Oncol. 2023 Jan;149(1):401-421. doi: 10.1007/s00432-022-04398-z. Epub 2022 Oct 28.