PMID- 36306511
OWN - NLM
STAT- MEDLINE
DCOM- 20221101
LR  - 20221101
IS  - 1945-0257 (Electronic)
IS  - 1945-0257 (Linking)
VI  - 26
IP  - 10
DP  - 2022 Oct
TI  - The Association Between the PTPN22 C1858T Variant and Vasculitis: A Meta-analysis 
      Update with Trial Sequential Analysis.
PG  - 492-500
LID - 10.1089/gtmb.2022.0119 [doi]
AB  - Objective: The present study was designed to determine whether the protein 
      tyrosine phosphatase non-receptor 22 (PTPN22) C1858T variant is associated with 
      susceptibility to vasculitis. Methods: A meta-analysis was conducted to evaluate 
      the association between the PTPN22 C1858T variant and vasculitis. A trial 
      sequential analysis was performed to evaluate the robustness of the 
      meta-analysis. Results: A total of 17 studies were included in this meta-analysis 
      which revealed a highly significant association between the PTPN22 T allele and 
      vasculitis of multiple types (odds ratio [OR] = 4.850, 95% confidence interval 
      [CI] = 3.043-7.729, p < 0.001). Meta-analysis by vasculitis type showed an 
      association between the T allele and risk of giant cell arteritis (GCA) and 
      antineutrophil cytoplasmic antibody-associated vasculitis (AAV) (OR = 7.505, 95% 
      CI = 3.605-15.62, p < 0.001; OR = 6.121, 95% CI = 3.216-11.65, p < 0.001). The 
      meta-analysis also indicated an association between the T allele and Takayasu's 
      arteritis, but not between the T allele and Behcet's disease or Henoch-Schonlein 
      purpura. TSA indicated that the observed association is conclusive with the 
      existing evidence. Conclusions: This meta-analysis confirms that the PTPN22 
      C1858T variant is associated with susceptibility to GCA and AAV.
FAU - Lee, Young Ho
AU  - Lee YH
AUID- ORCID: 0000-0003-4213-1909
AD  - Division of Rheumatology, Korea University Anam Hospital, Seoul, Korea.
FAU - Song, Gwan Gyu
AU  - Song GG
AD  - Division of Rheumatology, Korea University Anam Hospital, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
RN  - EC 3.1.3.48 (PTPN22 protein, human)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 22)
SB  - IM
MH  - Humans
MH  - *Genetic Predisposition to Disease/genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Alleles
MH  - Odds Ratio
MH  - *Vasculitis/genetics
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 22/genetics
OTO - NOTNLM
OT  - meta-analysis
OT  - protein tyrosine phosphatase nonreceptor 22
OT  - variant
OT  - vasculitis
EDAT- 2022/10/29 06:00
MHDA- 2022/11/02 06:00
CRDT- 2022/10/28 16:42
PHST- 2022/10/28 16:42 [entrez]
PHST- 2022/10/29 06:00 [pubmed]
PHST- 2022/11/02 06:00 [medline]
AID - 10.1089/gtmb.2022.0119 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2022 Oct;26(10):492-500. doi: 10.1089/gtmb.2022.0119.