PMID- 36306619
OWN - NLM
STAT- MEDLINE
DCOM- 20221122
LR  - 20221122
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 247
DP  - 2022 Dec 1
TI  - Chemical element concentrations in cord whole blood and the risk of preterm birth 
      for pregnant women in Guangdong, China.
PG  - 114228
LID - S0147-6513(22)01068-5 [pii]
LID - 10.1016/j.ecoenv.2022.114228 [doi]
AB  - Maternal exposure to chemical elements, including essential and non-essential 
      elements, have been found to be associated with preterm births (PTB). However, 
      few studies have measured element concentrations in cord whole blood, which 
      reflects activity at the maternal-fetal interface and may be biologically 
      associated with PTBs. In this study, we determined concentrations of 21 elements 
      in cord whole blood and explored the associations between element concentrations 
      and PTB in a nested case-control study within a birth cohort in Guangdong, China. 
      Finally, 515 preterm infants and 595 full-term infants were included. We 
      performed single-element and multi-element logistic regressions to evaluate 
      linear relationships between element concentrations and PTB. According to the 
      results of single-element models, most essential elements (including K, Ca, Si, 
      Zn, Se, Sr and Fe) were negatively associated with PTB, while Cu, V, Co and Sn 
      were positively associated with PTB. Of the non-essential elements, Sb, Tl, and U 
      were positively associated with PTB, while Pb was negatively associated with PTB. 
      The multi-element model results for most elements were similar, except that the 
      association between Mg and PTB was shown to be significantly positive, and the 
      association for Cu became much larger. A possible explanation is that the effects 
      of Mg and Cu may be influenced by other elements. We performed restricted cubic 
      spline (RCS) regressions and found significantly non-linear exposure-response 
      relationships for Mg, Se, Sr, K and Sb, indicating that the effects of these 
      elements on PTB are not simply detrimental or beneficial. We also examined the 
      joint effect using a Bayesian kernel machine regression (BKMR) model and found 
      the risk of PTB decreased significantly with element mixture concentration when 
      lnC was larger than the median. Bivariate interaction analysis suggested 
      antagonistic effects of Sb on Zn and Sr, which may be attributed to Sb negating 
      the antioxidant capacity of Zn and Sr. This study provides additional evidence 
      for the effect of element exposures on PTB, and will have implications for the 
      prevention of excessive exposures or inappropriate element supplementation during 
      pregnancy.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Wang, Zhaokun
AU  - Wang Z
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Peking University, Beijing 100191, China.
FAU - Huang, Shaodan
AU  - Huang S
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Peking University, Beijing 100191, China.
FAU - Zhang, Wenlou
AU  - Zhang W
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Peking University, Beijing 100191, China.
FAU - Zeng, Xiaowen
AU  - Zeng X
AD  - Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, 
      Guangdong Provincial Engineering Technology Research Center of Environmental and 
      Health Risk Assessment, Department of Occupational and Environmental Health, 
      School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
FAU - Chu, Chu
AU  - Chu C
AD  - Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, 
      Guangdong Provincial Engineering Technology Research Center of Environmental and 
      Health Risk Assessment, Department of Occupational and Environmental Health, 
      School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
FAU - Li, Qingqing
AU  - Li Q
AD  - Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, 
      Guangdong Provincial Engineering Technology Research Center of Environmental and 
      Health Risk Assessment, Department of Occupational and Environmental Health, 
      School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
FAU - Cui, Xinxin
AU  - Cui X
AD  - Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, 
      Guangdong Provincial Engineering Technology Research Center of Environmental and 
      Health Risk Assessment, Department of Occupational and Environmental Health, 
      School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
FAU - Wu, Qizhen
AU  - Wu Q
AD  - Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, 
      Guangdong Provincial Engineering Technology Research Center of Environmental and 
      Health Risk Assessment, Department of Occupational and Environmental Health, 
      School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
FAU - Dong, Guanghui
AU  - Dong G
AD  - Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, 
      Guangdong Provincial Engineering Technology Research Center of Environmental and 
      Health Risk Assessment, Department of Occupational and Environmental Health, 
      School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
FAU - Huang, Jinbo
AU  - Huang J
AD  - Department of Gynaecology and Obstetrics, Maternal and Child Health Hospital of 
      Maoming City, Maoming 525000, China.
FAU - Liu, Liling
AU  - Liu L
AD  - Department of Reproductive Medicine and Genetics Center. The People's Hospital of 
      Guangxi Zhuang Autonomous Region, 6 Taoyuan Road, Nanning, 530016, Guangxi, 
      China.
FAU - Tan, Weihong
AU  - Tan W
AD  - Department of Reproductive Medicine and Genetics Center. The People's Hospital of 
      Guangxi Zhuang Autonomous Region, 6 Taoyuan Road, Nanning, 530016, Guangxi, 
      China.
FAU - Shang, Xuejun
AU  - Shang X
AD  - Department of Andrology, Jinling Hospital, School of Medicine, Nanjing 
      University, Nanjing, 210002, China.
FAU - Kong, Minli
AU  - Kong M
AD  - Department of Gynaecology and Obstetrics, Maternal and Child Health Hospital of 
      Maoming City, Maoming 525000, China. Electronic address: kmlgdzy1963@163.com.
FAU - Deng, Furong
AU  - Deng F
AD  - Department of Occupational and Environmental Health Sciences, School of Public 
      Health, Peking University, Beijing 100191, China. Electronic address: 
      lotus321321@126.com.
LA  - eng
PT  - Journal Article
DEP - 20221025
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
SB  - IM
MH  - Humans
MH  - Infant, Newborn
MH  - Pregnancy
MH  - Female
MH  - *Premature Birth/epidemiology
MH  - Pregnant Women
MH  - Case-Control Studies
MH  - Bayes Theorem
MH  - Infant, Premature
MH  - China/epidemiology
OTO - NOTNLM
OT  - Cord whole blood
OT  - Element exposure
OT  - Exposure-response relationship
OT  - Nested case-control study
OT  - Preterm birth (PTB)
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/10/29 06:00
MHDA- 2022/11/23 06:00
CRDT- 2022/10/28 18:19
PHST- 2022/07/03 00:00 [received]
PHST- 2022/10/21 00:00 [revised]
PHST- 2022/10/21 00:00 [accepted]
PHST- 2022/10/29 06:00 [pubmed]
PHST- 2022/11/23 06:00 [medline]
PHST- 2022/10/28 18:19 [entrez]
AID - S0147-6513(22)01068-5 [pii]
AID - 10.1016/j.ecoenv.2022.114228 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2022 Dec 1;247:114228. doi: 10.1016/j.ecoenv.2022.114228. 
      Epub 2022 Oct 25.