PMID- 36308028
OWN - NLM
STAT- MEDLINE
DCOM- 20230224
LR  - 20230224
IS  - 1939-6376 (Electronic)
IS  - 1939-6368 (Linking)
VI  - 69
IP  - 1
DP  - 2023 Feb
TI  - Hyperhomocysteinemia in men and women of married couples with reproductive 
      disorders. What is the difference?
PG  - 75-85
LID - 10.1080/19396368.2022.2124896 [doi]
AB  - Hyperhomocysteinemia (HHcy) is an autosomal recessive inherited metabolic disease 
      caused by variations in folate metabolism genes, characterized by impaired 
      methionine metabolism and accumulation of homocysteine (Hcy) in the blood serum. 
      It was shown that men usually have higher plasma Hcy levels than women, but have 
      not yet assessed the leading factors of these differences, which is important for 
      the development of personalized protocols for the prevention of folate metabolism 
      disorders in couples with reproductive disorders. This study aimed to analyze the 
      effect of intergenic and gene-factor interactions on the risk of developing HHcy 
      in men and women of married couples with reproductive disorders. In our study 
      were involved 206 married Caucasian couples (206 males and 206 females) from 
      central regions of Ukraine with early pregnancy losses in the anamnesis. We found 
      that the incidence of HHcy in men was significantly higher than in women. Gender 
      differences in folic acid and vitamin B12 levels were identified. The best 
      predictors of HHcy in men (MTRR (A66G), MTHFR (C677T), MTR (A2756G), vitamin B12 
      level) and in women (MTHFR (C677T), MTR (A2756G), vitamin B12 level) were 
      selected by binary logistic regression. There was no significant difference in 
      the distribution of genotypes by the studied gene variants when comparing men and 
      women with HHcy. Our findings demonstrate that there is a gender difference in 
      the development of HHcy. This difference is caused by intergenic interaction and 
      by environmental factors, in particular, nutrition and vitamins consumption.
FAU - Rossokha, Zoia
AU  - Rossokha Z
AUID- ORCID: 0000-0002-4767-7364
AD  - Department of genetic diagnostics, State Institute of Genetic and Regenerative 
      Medicine National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.
AD  - State Institution "Reference-Centre for Molecular Diagnostic of Public Health 
      Ministry of Ukraine", Kyiv, Ukraine.
FAU - Fishchuk, Liliya
AU  - Fishchuk L
AUID- ORCID: 0000-0001-9999-7389
AD  - Department of genetic diagnostics, State Institute of Genetic and Regenerative 
      Medicine National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.
AD  - State Institution "Reference-Centre for Molecular Diagnostic of Public Health 
      Ministry of Ukraine", Kyiv, Ukraine.
FAU - Vorobei, Liudmyla
AU  - Vorobei L
AUID- ORCID: 0000-0002-8969-228X
AD  - Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine.
FAU - Medvedieva, Nataliia
AU  - Medvedieva N
AUID- ORCID: 0000-0002-8005-7220
AD  - State Institution "Reference-Centre for Molecular Diagnostic of Public Health 
      Ministry of Ukraine", Kyiv, Ukraine.
FAU - Popova, Olena
AU  - Popova O
AUID- ORCID: 0000-0002-8298-858X
AD  - State Institution "Reference-Centre for Molecular Diagnostic of Public Health 
      Ministry of Ukraine", Kyiv, Ukraine.
FAU - Vershyhora, Viktoriia
AU  - Vershyhora V
AUID- ORCID: 0000-0003-0220-2573
AD  - State Institution "Reference-Centre for Molecular Diagnostic of Public Health 
      Ministry of Ukraine", Kyiv, Ukraine.
FAU - Sheyko, Larysa
AU  - Sheyko L
AUID- ORCID: 0000-0001-9004-9307
AD  - Department of genetic diagnostics, State Institute of Genetic and Regenerative 
      Medicine National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.
AD  - Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine.
FAU - Brisevac, Ljudmila
AU  - Brisevac L
AUID- ORCID: 0000-0002-5200-1852
AD  - Department of genetic diagnostics, State Institute of Genetic and Regenerative 
      Medicine National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.
AD  - Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine.
FAU - Stroy, Dmytro
AU  - Stroy D
AUID- ORCID: 0000-0002-4329-4796
AD  - Department of genetic diagnostics, State Institute of Genetic and Regenerative 
      Medicine National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.
FAU - Gorovenko, Nataliia
AU  - Gorovenko N
AUID- ORCID: 0000-0003-4227-7166
AD  - Department of genetic diagnostics, State Institute of Genetic and Regenerative 
      Medicine National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.
AD  - Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine.
LA  - eng
PT  - Journal Article
DEP - 20221028
PL  - England
TA  - Syst Biol Reprod Med
JT  - Systems biology in reproductive medicine
JID - 101464963
RN  - 935E97BOY8 (Folic Acid)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Male
MH  - Pregnancy
MH  - Humans
MH  - Female
MH  - *Hyperhomocysteinemia/genetics
MH  - Genotype
MH  - Folic Acid
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/genetics
MH  - Reproduction
MH  - Vitamin B 12
OTO - NOTNLM
OT  - Hyperhomocysteinemia
OT  - folate cycle
OT  - gender
OT  - gene
OT  - reproductive disorders
EDAT- 2022/10/30 06:00
MHDA- 2023/02/25 06:00
CRDT- 2022/10/29 03:02
PHST- 2022/10/30 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2022/10/29 03:02 [entrez]
AID - 10.1080/19396368.2022.2124896 [doi]
PST - ppublish
SO  - Syst Biol Reprod Med. 2023 Feb;69(1):75-85. doi: 10.1080/19396368.2022.2124896. 
      Epub 2022 Oct 28.