PMID- 36308548
OWN - NLM
STAT- MEDLINE
DCOM- 20221114
LR  - 20230119
IS  - 1435-1463 (Electronic)
IS  - 0300-9564 (Print)
IS  - 0300-9564 (Linking)
VI  - 129
IP  - 12
DP  - 2022 Dec
TI  - Corticobasal syndrome and Parkinson's disease at the beginning: asymmetrical 
      patterns of MRI and Blink Reflex for early diagnosis.
PG  - 1427-1433
LID - 10.1007/s00702-022-02557-7 [doi]
AB  - Differential diagnosis between Parkinson's disease (PD) and corticobasal syndrome 
      (CBS) could be challenging at the early stage, due to the asymmetric onset of 
      both diseases. Despite the clinical overlap, the anatomical circuits involved in 
      these disorders are different. We evaluated R2 Blink Reflex Recovery Cycle 
      (R2BRRC) and cortical thickness (CTh) in drug-naive PD and CBS patients for 
      characterizing pathophysiological mechanisms underlying these conditions. 
      Patients with a clinically probable diagnosis of PD and possible CBS were 
      recruited. R2BRRC was evaluated bilaterally at interstimulus intervals (ISIs) of 
      100-150-200-300-400-500-750 ms. Asymmetry index (AI) of R2BRRC for each ISI was 
      computed. Patients underwent a structural brain MRI and hemisphere CTh and AI of 
      MRI was calculated. Fourteen drug-naive PD patients and 10 patients with early 
      CBS diagnosis were enrolled. R2BRRC of PD patients showed an increased brainstem 
      excitability for less affected side (LAS) stimulation at ISIs of 100 and 150 ms 
      (p < 0.001) compared to most affected side (MAS), whereas no differences between 
      LAS and MAS were found in CBS. AI of R2BRRC at ISI-100 ms showed significant 
      difference, being higher in PD. CTh analysis showed significant differences 
      between groups in hemisphere cortical volume contralateral to MAS, and, 
      conversely, AI of MRI was significantly higher in CBS. PD patients exhibited an 
      asymmetric pattern of brainstem excitability, compared to CBS. Conversely, CBS 
      patients showed an asymmetric pattern of cortical atrophy. This opposite pattern 
      of neurophysiological and structural abnormalities involving cortical and 
      subcortical brain structures could highlight the different pathophysiological 
      mechanisms underlying these disorders.
CI  - (c) 2022. The Author(s).
FAU - Donzuso, Giulia
AU  - Donzuso G
AD  - Department of Medical, Surgical Sciences and Advanced Technologies "GF 
      Ingrassia", University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.
FAU - Sciacca, Giorgia
AU  - Sciacca G
AD  - Department of Medical, Surgical Sciences and Advanced Technologies "GF 
      Ingrassia", University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.
FAU - Luca, Antonina
AU  - Luca A
AD  - Department of Medical, Surgical Sciences and Advanced Technologies "GF 
      Ingrassia", University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.
FAU - Cicero, Calogero E
AU  - Cicero CE
AD  - Department of Medical, Surgical Sciences and Advanced Technologies "GF 
      Ingrassia", University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.
FAU - Mostile, Giovanni
AU  - Mostile G
AD  - Department of Medical, Surgical Sciences and Advanced Technologies "GF 
      Ingrassia", University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.
FAU - Nicoletti, Alessandra
AU  - Nicoletti A
AD  - Department of Medical, Surgical Sciences and Advanced Technologies "GF 
      Ingrassia", University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.
FAU - Zappia, Mario
AU  - Zappia M
AD  - Department of Medical, Surgical Sciences and Advanced Technologies "GF 
      Ingrassia", University of Catania, Via Santa Sofia 78, 95123, Catania, Italy. 
      m.zappia@unict.it.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221029
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
SB  - IM
MH  - Humans
MH  - *Parkinson Disease/diagnostic imaging
MH  - Blinking
MH  - *Corticobasal Degeneration
MH  - Magnetic Resonance Imaging
MH  - Early Diagnosis
PMC - PMC9649477
OTO - NOTNLM
OT  - Blink reflex
OT  - Corticobasal syndrome
OT  - Diagnosis
OT  - Magnetic resonance imaging
OT  - Parkinson's disease
COIS- The authors declare no financial or other conflicts of interest.
EDAT- 2022/10/30 06:00
MHDA- 2022/11/15 06:00
PMCR- 2022/10/29
CRDT- 2022/10/29 11:13
PHST- 2022/08/23 00:00 [received]
PHST- 2022/10/19 00:00 [accepted]
PHST- 2022/10/30 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/10/29 11:13 [entrez]
PHST- 2022/10/29 00:00 [pmc-release]
AID - 10.1007/s00702-022-02557-7 [pii]
AID - 2557 [pii]
AID - 10.1007/s00702-022-02557-7 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2022 Dec;129(12):1427-1433. doi: 
      10.1007/s00702-022-02557-7. Epub 2022 Oct 29.