PMID- 36308653 OWN - NLM STAT- MEDLINE DCOM- 20230224 LR - 20230224 IS - 1614-7499 (Electronic) IS - 0944-1344 (Linking) VI - 30 IP - 9 DP - 2023 Feb TI - Exploratory analysis of the association between organophosphate ester mixtures with high blood pressure of children and adolescents aged 8-17 years: cross-sectional findings from the National Health and Nutrition Examination Survey. PG - 22900-22912 LID - 10.1007/s11356-022-23740-z [doi] AB - Epidemiological studies on the effect of organophosphate esters (OPEs) on high blood pressure (BP) among children and adolescents are scant. Therefore, the main objective of the present study was to explore the effect of exposure to OPEs on high BP among children and adolescents. A total of 1340 participants were included in the current analyses. Multivariable logistic regression models were implemented to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs) to examine the association between OPE metabolites and high BP. We also assessed the modified effect of sex, age, and overweight/obesity on this association. Furthermore, quantile g-computation (Qgcomp) and Bayesian kernel machine regression (BKMR) were exhibited to analyze the association between multiple OPE metabolite mixtures and high BP. After adjusting for covariates, the highest (vs. lowest) tertiles of bis (1-choloro-2-propyl) phosphate (BCPP), bis-2-chloroethyl phosphate (BCEP), and di-n-butyl phosphate (DBUP) were associated with 1.23 (95% CI: 0.83, 1.83), 1.27 (95% CI: 0.85, 1.92), and 1.01 (95% CI: 0.67, 1.53) odds ratios for high BP, respectively. In the Qgcomp, a quartile increase in OPE metabolite mixtures was weakly associated with an elevated risk of high BP (adjusted OR: 1.06, 95CI%: 0.81, 1.37). The results from BKMR showed a positive trend of association between OPE metabolite mixture on the risk of high BP. In conclusion, our study demonstrated that higher levels of BCPP, BCEP, and DBUP were weakly associated with high BP among US children and adolescents. Moderate evidence suggested OPE metabolite mixtures had positive joint effects on high BP. Consequently, longitudinal studies with repeated measurements are warranted to examine the relationships between multiple OPE metabolites and high blood pressure among children and adolescents. CI - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Guo, Xianwei AU - Guo X AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, People's Republic of China. FAU - Ke, Yujie AU - Ke Y AD - Children's Hospital of Anhui Medical University, 39 Wangjiang East Road, Hefei, 230051, Anhui, People's Republic of China. FAU - Wu, Birong AU - Wu B AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, People's Republic of China. FAU - Song, Qiuxia AU - Song Q AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, People's Republic of China. FAU - Sun, Chenyu AU - Sun C AD - AMITA Health Saint Joseph Hospital Chicago, 2900 N. Lake Shore Drive, Chicago, IL, 60657, USA. FAU - Li, Yaru AU - Li Y AD - Internal Medicine, Swedish Hospital, 5140 N California Ave, Chicago, IL, 60625, USA. FAU - Wang, Hao AU - Wang H AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, People's Republic of China. FAU - Su, Wanying AU - Su W AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, People's Republic of China. FAU - Liang, Qiwei AU - Liang Q AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, People's Republic of China. AD - Children's Hospital of Anhui Medical University, 39 Wangjiang East Road, Hefei, 230051, Anhui, People's Republic of China. FAU - Lowe, Scott AU - Lowe S AD - College of Osteopathic Medicine, Kansas City University, 1750 Independence Ave, Kansas City, MO, 64106, USA. FAU - Bentley, Rachel AU - Bentley R AD - College of Osteopathic Medicine, Kansas City University, 1750 Independence Ave, Kansas City, MO, 64106, USA. FAU - Song, Evelyn J AU - Song EJ AD - Division of Hospital Medicine, Department of Medicine, University of California, San Francisco, CA, USA. FAU - King, Bethany AU - King B AD - Internal Medicine, MercyOne Des Moines Medical Center, 1111 6Th Avenue, Des Moines, IA, 50314, USA. FAU - Zhou, Qin AU - Zhou Q AD - Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. FAU - Xie, Ruijin AU - Xie R AD - School of Medicine, Jiangnan University, No. 1800, Lihu Avenue, Wuxi, 214122, People's Republic of China. FAU - Deng, Fang AU - Deng F AD - Children's Hospital of Anhui Medical University, 39 Wangjiang East Road, Hefei, 230051, Anhui, People's Republic of China. dengfang@ahmu.edu.cn. LA - eng PT - Journal Article DEP - 20221029 PL - Germany TA - Environ Sci Pollut Res Int JT - Environmental science and pollution research international JID - 9441769 RN - 0 (Esters) RN - 0 (Organophosphates) RN - 0 (Phosphates) RN - 0 (Flame Retardants) SB - IM MH - Humans MH - Child MH - Adolescent MH - Nutrition Surveys MH - Cross-Sectional Studies MH - Bayes Theorem MH - Esters MH - Organophosphates MH - Phosphates MH - *Hypertension MH - *Flame Retardants/metabolism OTO - NOTNLM OT - BKMR OT - Blood pressure OT - NHANES OT - Organophosphate esters OT - Qgcomp EDAT- 2022/10/30 06:00 MHDA- 2023/02/25 06:00 CRDT- 2022/10/29 11:20 PHST- 2022/06/17 00:00 [received] PHST- 2022/10/17 00:00 [accepted] PHST- 2022/10/30 06:00 [pubmed] PHST- 2023/02/25 06:00 [medline] PHST- 2022/10/29 11:20 [entrez] AID - 10.1007/s11356-022-23740-z [pii] AID - 10.1007/s11356-022-23740-z [doi] PST - ppublish SO - Environ Sci Pollut Res Int. 2023 Feb;30(9):22900-22912. doi: 10.1007/s11356-022-23740-z. Epub 2022 Oct 29.