PMID- 36309775
OWN - NLM
STAT- MEDLINE
DCOM- 20221101
LR  - 20221212
IS  - 1614-0575 (Electronic)
IS  - 1613-6071 (Print)
IS  - 1613-6071 (Linking)
VI  - 18
IP  - 3
DP  - 2022 Sep 28
TI  - Prevalence and Specific Manifestations of Non-alcoholic Fatty Liver Disease 
      (NAFLD) and Diabetes Mellitus Type 2 Association in a Moroccan Population: A 
      Cross-sectional Study.
PG  - 140-145
LID - 10.1900/RDS.2022.18.140 [doi]
AB  - OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is recognized as a common 
      cause of chronic liver disease worldwide. Its association with type 2 diabetes 
      mellitus (T2DM) is known to increase the risk of degenerative complications of 
      diabetes and the likelihood of developing severe hepatic injuries. The objective 
      of this study was to assess the prevalence of NAFLD and to describe the 
      characteristics of its association with T2DM. METHODS: This was a descriptive 
      analytical study, involving patients with T2DM with no history of alcohol 
      consumption, viral hepatitis, hepatotoxic medications, or other chronic liver 
      diseases. The patients underwent an investigation of NAFLD including abdominal 
      ultrasound, non-invasive biomarkers of liver fibrosis, elastography and 
      ultrasound-guided liver biopsy. RESULTS: We collected data from 180 patients with 
      a mean age of 59.3 +/- 10.9 years with strong female predominance. The mean 
      duration of diabetes progression was 9.2 +/- 7.3 years. Hepatic sonography showed 
      signs of NAFLD in 45.6% of cases. Non-invasive hepatic biomarkers indicated 
      significant fibrosis in 18.3% of cases. Overall, 21% of patients underwent an 
      elastography evaluation, revealing severe fibrosis or cirrhosis in 15.4% of 
      patients. The diagnosis of NASH (Non-alcoholic steatohepatitis) was confirmed 
      histologically in 3 patients. The overall prevalence of NAFLD was 45.6%. Patients 
      with NAFLD had a statistically significant incidence of obesity, metabolic 
      syndrome, hypertension, dyslipidemia, macrovascular complications, and 
      hypertriglyceridemia (p < 0.05). CONCLUSIONS: The combination of NAFLD and T2DM 
      is often found in patients with obesity or metabolic syndrome. The presence of 
      NAFLD can be responsible for increased morbidity and important cardiovascular 
      risks in patients with T2DM.
FAU - Assarrar, Imane
AU  - Assarrar I
AD  - Department of Endocrinology-Diabetology and Nutrition, Mohammed Vi University 
      Hospital Center, Faculty of Medicine and Pharmacy, University of Mohammed First, 
      Oujda, Morocco.
FAU - Messaoudi, Najoua
AU  - Messaoudi N
AD  - Department of Endocrinology-Diabetology and Nutrition, Mohammed Vi University 
      Hospital Center, Faculty of Medicine and Pharmacy, University of Mohammed First, 
      Oujda, Morocco.
FAU - Ongoth, Farel Elilie Mawa
AU  - Ongoth FEM
AD  - Department of Endocrinology-Diabetology and Nutrition, Mohammed Vi University 
      Hospital Center, Faculty of Medicine and Pharmacy, University of Mohammed First, 
      Oujda, Morocco.
FAU - Abdellaoui, Wahiba
AU  - Abdellaoui W
AD  - Department of Endocrinology-Diabetology and Nutrition, Mohammed Vi University 
      Hospital Center, Faculty of Medicine and Pharmacy, University of Mohammed First, 
      Oujda, Morocco.
FAU - Malki, Abdessamad
AU  - Malki A
AD  - Department of Endocrinology-Diabetology and Nutrition, Mohammed Vi University 
      Hospital Center, Faculty of Medicine and Pharmacy, University of Mohammed First, 
      Oujda, Morocco.
FAU - Rouf, Siham
AU  - Rouf S
AD  - Laboratory of Epidemiology, Clinical Research and Public Health, Faculty of 
      Medicine and Pharmacy, University of Mohammed First, Oujda, Morocco.
FAU - Abda, Naima
AU  - Abda N
AD  - Laboratory of Epidemiology, Clinical Research and Public Health, Faculty of 
      Medicine and Pharmacy, University of Mohammed First, Oujda, Morocco.
FAU - Ismaili, Zahi
AU  - Ismaili Z
AD  - Department of Hepatology and Gastroentorology, Mohammed Vi University Hospital 
      Center, Faculty of Medicine and Pharmacy, University of Mohammed First, Oujda, 
      Morocco.
FAU - Latrech, Hanane
AU  - Latrech H
AD  - Department of Endocrinology-Diabetology and Nutrition, Mohammed Vi University 
      Hospital Center, Faculty of Medicine and Pharmacy, University of Mohammed First, 
      Oujda, Morocco.
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - Rev Diabet Stud
JT  - The review of diabetic studies : RDS
JID - 101227575
SB  - IM
MH  - Humans
MH  - Female
MH  - Middle Aged
MH  - Aged
MH  - Male
MH  - *Non-alcoholic Fatty Liver Disease/complications/epidemiology
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Cross-Sectional Studies
MH  - *Metabolic Syndrome/complications
MH  - Prevalence
MH  - Risk Factors
MH  - Liver Cirrhosis/complications/epidemiology
MH  - Obesity/complications
PMC - PMC9652707
COIS- The authors declare no conflicts of interest.
EDAT- 2022/10/31 06:00
MHDA- 2022/11/02 06:00
PMCR- 2022/09/30
CRDT- 2022/10/30 01:12
PHST- 2022/10/30 01:12 [entrez]
PHST- 2022/10/31 06:00 [pubmed]
PHST- 2022/11/02 06:00 [medline]
PHST- 2022/09/30 00:00 [pmc-release]
AID - RDS-18-140 [pii]
AID - 10.1900/RDS.2022.18.140 [doi]
PST - ppublish
SO  - Rev Diabet Stud. 2022 Sep 28;18(3):140-145. doi: 10.1900/RDS.2022.18.140.