PMID- 36310091 OWN - NLM STAT- MEDLINE DCOM- 20230503 LR - 20230505 IS - 1460-2199 (Electronic) IS - 1047-3211 (Linking) VI - 33 IP - 9 DP - 2023 Apr 25 TI - Neurovascular decoupling measured with quantitative susceptibility mapping is associated with cognitive decline in patients with type 2 diabetes. PG - 5336-5346 LID - 10.1093/cercor/bhac422 [doi] AB - Disturbance of neurovascular coupling (NVC) is suggested to be one potential mechanism in type 2 diabetes mellitus (T2DM) associated mild cognitive impairment (MCI). However, NVC evidence derived from functional magnetic resonance imaging ignores the relationship of neuronal activity with vascular injury. Twenty-seven T2DM patients without MCI and thirty healthy controls were prospectively enrolled. Brain regions with changed susceptibility detected by quantitative susceptibility mapping (QSM) were used as seeds for functional connectivity (FC) analysis. NVC coefficients were estimated using combined degree centrality (DC) with susceptibility or cerebral blood flow (CBF). Partial correlations between neuroimaging indicators and cognitive decline were investigated. In T2DM group, higher susceptibility values in right hippocampal gyrus (R.PHG) were found and were negatively correlated with Naming Ability of Montreal Cognitive Assessment. FC increased remarkably between R.PHG and right middle temporal gyrus (R.MTG), right calcarine gyrus (R.CAL). Both NVC coefficients (DC-QSM and DC-CBF) reduced in R.PHG and increased in R.MTG and R.CAL. Both NVC coefficients in R.PHG and R.MTG increased with the improvement of cognitive ability, especially for executive function. These demonstrated that QSM and DC-QSM coefficients can be promising biomarkers for early evaluation of cognitive decline in T2DM patients and help to better understand the mechanism of NVC. CI - (c) The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. FAU - Ni, Min-Hua AU - Ni MH AD - Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an 710038, Shaanxi, China. AD - Faculty of Medical Technology, Shaanxi University of Chinese Medicine, 1 Middle Section of Shiji Road, Xian yang, Shaanxi 712046, China. FAU - Li, Ze-Yang AU - Li ZY AD - Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an 710038, Shaanxi, China. FAU - Sun, Qian AU - Sun Q AD - Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an 710038, Shaanxi, China. FAU - Yu, Ying AU - Yu Y AD - Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an 710038, Shaanxi, China. FAU - Yang, Yang AU - Yang Y AD - Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an 710038, Shaanxi, China. FAU - Hu, Bo AU - Hu B AD - Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an 710038, Shaanxi, China. FAU - Ma, Teng AU - Ma T AD - Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an 710038, Shaanxi, China. FAU - Xie, Hao AU - Xie H AD - Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an 710038, Shaanxi, China. FAU - Li, Si-Ning AU - Li SN AD - Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an 710038, Shaanxi, China. AD - Faculty of Medical Technology, Xi'an Medical University, 1 Xinwang Road, Xi'an, Shaanxi 710016, China. FAU - Tao, Lan-Qiu AU - Tao LQ AD - Student Brigade, Fourth Military Medical University, 169 Changle Road, Xi'an, Shaanxi 710032, China. FAU - Yuan, Ding-Xin AU - Yuan DX AD - Student Brigade, Fourth Military Medical University, 169 Changle Road, Xi'an, Shaanxi 710032, China. FAU - Zhu, Jun-Ling AU - Zhu JL AD - Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an 710038, Shaanxi, China. FAU - Yan, Lin-Feng AU - Yan LF AD - Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an 710038, Shaanxi, China. FAU - Cui, Guang-Bin AU - Cui GB AUID- ORCID: 0000-0002-7935-9803 AD - Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an 710038, Shaanxi, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Cereb Cortex JT - Cerebral cortex (New York, N.Y. : 1991) JID - 9110718 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/complications/pathology MH - Brain MH - *Cognitive Dysfunction/pathology MH - Cognition/physiology MH - Temporal Lobe MH - Magnetic Resonance Imaging/methods OTO - NOTNLM OT - cognitive decline OT - iron deposition OT - neurovascular coupling OT - quantitative susceptibility mapping OT - type 2 diabetes mellitus EDAT- 2022/10/31 06:00 MHDA- 2023/05/03 06:42 CRDT- 2022/10/30 22:42 PHST- 2022/08/11 00:00 [received] PHST- 2022/09/26 00:00 [revised] PHST- 2022/09/28 00:00 [accepted] PHST- 2023/05/03 06:42 [medline] PHST- 2022/10/31 06:00 [pubmed] PHST- 2022/10/30 22:42 [entrez] AID - 6779888 [pii] AID - 10.1093/cercor/bhac422 [doi] PST - ppublish SO - Cereb Cortex. 2023 Apr 25;33(9):5336-5346. doi: 10.1093/cercor/bhac422.