PMID- 36312626 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221102 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 14 IP - 9 DP - 2022 Sep TI - The Mediating Role of Resilience and Electronic Health Literacy in the Relationship Between Pandemic Fatigue and Adherence to Preventive Behaviours Against COVID-19. PG - e29553 LID - 10.7759/cureus.29553 [doi] LID - e29553 AB - INTRODUCTION: There is emerging literature on the decline in adherence to preventive measures against the COVID-19 pandemic, a phenomenon of pandemic fatigue (PF). However, academics and policymakers have debated its existence and consequences. We conducted this study to explore this phenomenon, its existence, determinants, and relation to adherence to COVID-19 preventive measures, and the mediating role of resilience, fear of COVID-19, and electronic health literacy about COVID-19 in this relationship. METHODS: This cross-sectional online study was conducted from April to June 2021 using a convenience sample of 650 Saudi adults from all regions of Saudi Arabia using a reliable questionnaire. A structural equation model (SEM) was used for mediation analysis. RESULTS: The results revealed a moderate level of PF among Saudi adults. Younger patients experienced more PF. Fear of COVID-19 had a non-significant (p=0.127) effect on PF. SEM analysis revealed that both resilience and electronic health literacy significantly (p=0.000) mediated the relationship between PF and adherence to preventive measures, and acted as protective factors. In conclusion, there is evidence that PF exists and negatively affects adherence to preventive measures. CONCLUSION: Policymakers should apply evidence-based programs to increase public resilience, particularly targeting young adults, as the results of the current study shed light on its protective mediating role against PF. Increasing electronic health literacy is an effective strategy for preventing PF through an increase in the perceived effectiveness of preventive measures. CI - Copyright (c) 2022, Hassanien et al. FAU - Hassanien, Noha S AU - Hassanien NS AD - Biostatistics, Alexandria University, Alexandria, EGY. FAU - Adawi, Abdu M AU - Adawi AM AD - Preventive Medicine, Ministry of Health Saudi Arabia, Riyadh, SAU. FAU - Alzahrani, Turki A AU - Alzahrani TA AD - Preventive Medicine, Ministry of Health Saudi Arabia, King Abdulaziz Hospital, Taif, SAU. FAU - Adawi, Essa A AU - Adawi EA AD - Surgery, Jazan University, Jazan, SAU. LA - eng PT - Journal Article DEP - 20220925 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC9595032 OTO - NOTNLM OT - covid-19 OT - health literacy OT - pandemic fatigue OT - resilience OT - structural equation model COIS- The authors have declared that no competing interests exist. EDAT- 2022/11/01 06:00 MHDA- 2022/11/01 06:01 PMCR- 2022/09/25 CRDT- 2022/10/31 04:42 PHST- 2022/09/25 00:00 [accepted] PHST- 2022/10/31 04:42 [entrez] PHST- 2022/11/01 06:00 [pubmed] PHST- 2022/11/01 06:01 [medline] PHST- 2022/09/25 00:00 [pmc-release] AID - 10.7759/cureus.29553 [doi] PST - epublish SO - Cureus. 2022 Sep 25;14(9):e29553. doi: 10.7759/cureus.29553. eCollection 2022 Sep.