PMID- 36312666 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221102 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 14 IP - 9 DP - 2022 Sep TI - Durable Complete Remission With Combination of Stereotactic Body Radiation Therapy (SBRT) and Talimogene Laherparepvec (TVEC) Followed by Ipilimumab in Refractory Metastatic Melanoma. PG - e29573 LID - 10.7759/cureus.29573 [doi] LID - e29573 AB - Metastatic melanoma refractory to checkpoint inhibitors is a challenging clinical scenario. We present the case of a patient who was refractory to standard of care but was able to achieve a durable complete remission with the combination of stereotactic body radiation therapy (SBRT), talimogene laherparepvec (TVEC), and ipilimumab. CI - Copyright (c) 2022, Wolfe et al. FAU - Wolfe, Zachary AU - Wolfe Z AD - Hematology and Medical Oncology, Lehigh Valley Topper Cancer Institute, Allentown, USA. FAU - Blackham, Aaron AU - Blackham A AD - Surgical Oncology, Lehigh Valley Topper Cancer Institute, Allentown, USA. FAU - McIntosh, Alyson AU - McIntosh A AD - Radiation Oncology, Lehigh Valley Cancer Institute, Allentown, USA. FAU - Miller, Angela AU - Miller A AD - Hematology and Medical Oncology, Lehigh Valley Topper Cancer Institute, Allentown, USA. FAU - Sheikh, Hina AU - Sheikh H AD - Pathology, Health Network Laboratories, Allentown, USA. FAU - Nair, Suresh AU - Nair S AD - Hematology and Oncology, Lehigh Valley Cancer Institute, Allentown, USA. LA - eng PT - Case Reports DEP - 20220925 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC9596194 OTO - NOTNLM OT - immunotherapy OT - melanoma OT - oncolytic viruses OT - radiation therapy OT - targeted therapeutics COIS- The authors have declared that no competing interests exist. EDAT- 2022/11/01 06:00 MHDA- 2022/11/01 06:01 PMCR- 2022/09/25 CRDT- 2022/10/31 04:42 PHST- 2022/09/20 00:00 [accepted] PHST- 2022/10/31 04:42 [entrez] PHST- 2022/11/01 06:00 [pubmed] PHST- 2022/11/01 06:01 [medline] PHST- 2022/09/25 00:00 [pmc-release] AID - 10.7759/cureus.29573 [doi] PST - epublish SO - Cureus. 2022 Sep 25;14(9):e29573. doi: 10.7759/cureus.29573. eCollection 2022 Sep.