PMID- 36313014
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221102
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 14
DP  - 2022
TI  - Altered functional association and couplings: Effective diagnostic neuromarkers 
      for Alzheimer's disease.
PG  - 1009632
LID - 10.3389/fnagi.2022.1009632 [doi]
LID - 1009632
AB  - Alzheimer's disease (AD) is a common neurodegenerative disorder causing dementia 
      in the elderly population. Functional disconnection of brain is considered to be 
      the main cause of AD. In this study, we applied a newly developed association 
      (Asso) mapping approach to directly quantify the functional disconnections and to 
      explore the diagnostic effects for AD with resting-state functional magnetic 
      resonance imaging data from 36 AD patients and 42 age-, gender-, and 
      education-matched healthy controls (HC). We found that AD patients showed 
      decreased Asso in left dorsoanterior insula (INS) while increased functional 
      connections of INS with right medial prefrontal cortex (MPFC) and left posterior 
      cingulate cortex (PCC). The changed Asso and functional connections were closely 
      associated with cognitive performances. In addition, the reduced Asso and 
      increased functional connections could serve as effective neuromarkers to 
      distinguish AD patients from HC. Our research provided new evidence for 
      functional disconnections in AD and demonstrated that functional disconnections 
      between cognition-memory networks may be potential early biomarkers for AD.
CI  - Copyright (c) 2022 Zhao, Chen, Ding, Liu and Wu.
FAU - Zhao, Chongyi
AU  - Zhao C
AD  - Faculty of Life Science and Technology, Kunming University of Science and 
      Technology, Kunming, China.
AD  - Department of Gynecology, The First People's Hospital of Yunnan Province, Kunming 
      University of Science and Technology, Kunming, China.
FAU - Chen, Meiling
AU  - Chen M
AD  - Department of Clinical Psychology, The First People's Hospital of Yunnan 
      Province, Kunming University of Science and Technology, Kunming, China.
FAU - Ding, Zhiyong
AU  - Ding Z
AD  - Department of Medical Imaging, Qujing Maternal and Child Health Care Hospital, 
      Kunming University of Science and Technology, Qujing, China.
FAU - Liu, Chunyan
AU  - Liu C
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Neuromodulation, Beijing, China.
FAU - Wu, Xiaomei
AU  - Wu X
AD  - Department of Gynecology, The First People's Hospital of Yunnan Province, Kunming 
      University of Science and Technology, Kunming, China.
LA  - eng
PT  - Journal Article
DEP - 20221013
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC9606803
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - association mapping
OT  - biomarker
OT  - disconnection
OT  - functional connectivity
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/01 06:00
MHDA- 2022/11/01 06:01
PMCR- 2022/01/01
CRDT- 2022/10/31 04:49
PHST- 2022/08/02 00:00 [received]
PHST- 2022/09/05 00:00 [accepted]
PHST- 2022/10/31 04:49 [entrez]
PHST- 2022/11/01 06:00 [pubmed]
PHST- 2022/11/01 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2022.1009632 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2022 Oct 13;14:1009632. doi: 10.3389/fnagi.2022.1009632. 
      eCollection 2022.