PMID- 36313061
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221102
IS  - 2287-1098 (Print)
IS  - 2287-8602 (Electronic)
IS  - 2287-1098 (Linking)
VI  - 27
IP  - 3
DP  - 2022 Sep 30
TI  - Effects of Fruit and Vegetable Polyphenols on the Glycemic Control and Metabolic 
      Parameters in Type 2 Diabetes Mellitus: A Review.
PG  - 257-264
LID - 10.3746/pnf.2022.27.3.257 [doi]
AB  - The high prevalence of diabetes in recent decades has been associated with 
      lifestyle changes and dietary habits correlated with economic development. Fruits 
      and vegetables are a vital source of nutraceuticals and components of the healthy 
      diet recommended in the medical nutrition therapy for type 2 diabetes mellitus 
      (T2DM) to prevent hyperglycemia and related complications. They are low in 
      calories and rich in dietary fiber, consist of many polyphenols, and are an 
      essential component of a healthy lifestyle. Recently, researchers have developed 
      a significant interest in understanding the effects of polyphenols (flavonoids 
      and non-flavonoids) on blood glucose levels. In this review, the authors 
      summarize the effects of polyphenols commonly found in the fruits and vegetables, 
      such as resveratrol and anthocyanins, on the glycemic control and metabolic 
      parameters, based on human clinical trials. Significant reductions in fasting 
      blood glucose, glycated hemoglobin, and low-density lipoprotein cholesterol 
      levels were reported after resveratrol, anthocyanin, and naringin were 
      administered to patients with prediabetes and diabetes. Decreased insulin levels 
      were observed after resveratrol intervention but not with the other types of 
      polyphenols. These effects of polyphenolic compounds on the glycemic and 
      metabolic parameters might be mediated by multiple pathophysiological mechanisms, 
      such as activating regulator proteins to increase insulin signaling and 
      eventually suppress insulin resistance. The benefits of certain polyphenols on 
      T2DM remain ambiguous; therefore, further studies, especially clinical trials, 
      are required to substantiate the available evidence.
CI  - Copyright (c) 2022 by The Korean Society of Food Science and Nutrition. All rights 
      Reserved.
FAU - Zin, Che Anis Jauharah Che Mohd
AU  - Zin CAJCM
AUID- ORCID: 0000-0002-0604-3365
AD  - Nutrition Program, School of Health Sciences, Universiti Sains Malaysia, Kubang 
      Kerian, Kelantan 16150, Malaysia.
FAU - Mohamed, Wan Mohd Izani Wan
AU  - Mohamed WMIW
AUID- ORCID: 0000-0001-9110-8380
AD  - Department of Internal Medicine, School of Medical Sciences, Universiti Sains 
      Malaysia, Kubang Kerian, Kelantan 16150, Malaysia.
FAU - Khan, Nurzalina Abdul Karim
AU  - Khan NAK
AUID- ORCID: 0000-0002-7806-6400
AD  - School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang 
      11800, Malaysia.
FAU - Ishak, Wan Rosli Wan
AU  - Ishak WRW
AUID- ORCID: 0000-0001-7650-0499
AD  - Nutrition Program, School of Health Sciences, Universiti Sains Malaysia, Kubang 
      Kerian, Kelantan 16150, Malaysia.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Korea (South)
TA  - Prev Nutr Food Sci
JT  - Preventive nutrition and food science
JID - 101586663
PMC - PMC9585403
OTO - NOTNLM
OT  - diabetes mellitus
OT  - glucose
OT  - intervention
OT  - polyphenol
OT  - vegetable
COIS- AUTHOR DISCLOSURE STATEMENT The authors declare no conflict of interest.
EDAT- 2022/11/01 06:00
MHDA- 2022/11/01 06:01
PMCR- 2022/09/30
CRDT- 2022/10/31 04:50
PHST- 2022/10/31 04:50 [entrez]
PHST- 2022/11/01 06:00 [pubmed]
PHST- 2022/11/01 06:01 [medline]
PHST- 2022/09/30 00:00 [pmc-release]
AID - pnfs-27-3-257 [pii]
AID - 10.3746/pnf.2022.27.3.257 [doi]
PST - ppublish
SO  - Prev Nutr Food Sci. 2022 Sep 30;27(3):257-264. doi: 10.3746/pnf.2022.27.3.257.