PMID- 36313533
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221102
IS  - 2214-031X (Print)
IS  - 2214-0328 (Electronic)
IS  - 2214-031X (Linking)
VI  - 37
DP  - 2022 Nov
TI  - Therapeutic effect of human umbilical cord mesenchymal stem cells in early 
      traumatic osteonecrosis of the femoral head.
PG  - 126-142
LID - 10.1016/j.jot.2022.09.008 [doi]
AB  - BACKGROUND: Osteonecrosis of the femoral head (ONFH) is a refractory disease due 
      to its unclear pathomechanism. Therapies during the early stage of ONFH have not 
      achieved satisfactory results. Therefore, this study aims to explore the 
      available evidence for the therapeutic effect of human umbilical cord mesenchymal 
      stem cells (HUCMSCs) on early-stage traumatic ONFH. METHODS: Early-stage 
      traumatic ONFH was established. The femoral heads of rats were then locally 
      administered HUCMSCs. Four weeks and eight weeks after surgery, bone repair of 
      the necrotic area in the femoral head was analyzed to evaluate the therapeutic 
      effect of HUCMSCs using micro-CT, histopathological staining, immunofluorescence 
      staining, Luminex. RESULTS: HUCMSCs were still present in the femoral head four 
      weeks later, and the morphological, micro-CT and histopathological outcomes in 
      the 4-week HUCMSC-treated group were better than those in the model, NS and 
      8-week HUCMSC-treated groups. Local transplantation of HUCMSCs promoted bone 
      repair and prevented bone loss in the necrotic area of the femoral head. 
      CONCLUSIONS: HUCMSCs can survive and positively affect the femoral head through 
      local transplantation in early-stage traumatic ONFH. The conclusions of this 
      study can provide a treatment option for patients who have ONFH and can serve as 
      basic research on the advanced development of this disease. THE TRANSLATIONAL 
      POTENTIAL OF THIS ARTICLE: The study indicated that the positive effect of 
      exogenous HUCMSCs in the treatment of early-stage traumatic ONFH provides the 
      solid basis and guidance for the clinical application of HUCMSCs.
CI  - (c) 2022 The Authors.
FAU - Zhao, Jun
AU  - Zhao J
AD  - Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory 
      (No BZ0128), Beijing Key Lab of Regenerative Medicine in Orthopedics Key 
      Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing, 100853, China.
FAU - Meng, Haoye
AU  - Meng H
AD  - Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory 
      (No BZ0128), Beijing Key Lab of Regenerative Medicine in Orthopedics Key 
      Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing, 100853, China.
FAU - Liao, Sida
AU  - Liao S
AD  - Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory 
      (No BZ0128), Beijing Key Lab of Regenerative Medicine in Orthopedics Key 
      Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing, 100853, China.
FAU - Su, Yaoyu
AU  - Su Y
AD  - Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory 
      (No BZ0128), Beijing Key Lab of Regenerative Medicine in Orthopedics Key 
      Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing, 100853, China.
FAU - Guo, Li
AU  - Guo L
AD  - The Eight Medical Center of PLA General Hospital, China.
FAU - Wang, Aiyuan
AU  - Wang A
AD  - Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory 
      (No BZ0128), Beijing Key Lab of Regenerative Medicine in Orthopedics Key 
      Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing, 100853, China.
FAU - Xu, Wenjing
AU  - Xu W
AD  - Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory 
      (No BZ0128), Beijing Key Lab of Regenerative Medicine in Orthopedics Key 
      Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing, 100853, China.
FAU - Zhou, Hao
AU  - Zhou H
AD  - Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory 
      (No BZ0128), Beijing Key Lab of Regenerative Medicine in Orthopedics Key 
      Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing, 100853, China.
FAU - Peng, Jiang
AU  - Peng J
AD  - Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory 
      (No BZ0128), Beijing Key Lab of Regenerative Medicine in Orthopedics Key 
      Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing, 100853, China.
LA  - eng
PT  - Journal Article
DEP - 20221014
PL  - Singapore
TA  - J Orthop Translat
JT  - Journal of orthopaedic translation
JID - 101625127
PMC - PMC9582590
OTO - NOTNLM
OT  - HUCMSCs
OT  - Osteonecrosis of the femoral head
OT  - Therapeutic effect
COIS- Author Jun Zhao, Author Haoye Meng, Author Sida Liao, Author Yaoyu Su, Author Li 
      Guo, Author Aiyuan Wang, Author Wenjing Xu, Author Hao Zhou and Author Jiang Peng 
      declare that they have no conflicts of interest.
EDAT- 2022/11/01 06:00
MHDA- 2022/11/01 06:01
PMCR- 2022/10/14
CRDT- 2022/10/31 05:00
PHST- 2022/05/01 00:00 [received]
PHST- 2022/09/10 00:00 [revised]
PHST- 2022/09/13 00:00 [accepted]
PHST- 2022/10/31 05:00 [entrez]
PHST- 2022/11/01 06:00 [pubmed]
PHST- 2022/11/01 06:01 [medline]
PHST- 2022/10/14 00:00 [pmc-release]
AID - S2214-031X(22)00093-6 [pii]
AID - 10.1016/j.jot.2022.09.008 [doi]
PST - epublish
SO  - J Orthop Translat. 2022 Oct 14;37:126-142. doi: 10.1016/j.jot.2022.09.008. 
      eCollection 2022 Nov.