PMID- 36313749
OWN - NLM
STAT- MEDLINE
DCOM- 20221101
LR  - 20221102
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - Prolactin is associated with bone mineral density in subjects with type 2 
      diabetes mellitus.
PG  - 964808
LID - 10.3389/fendo.2022.964808 [doi]
LID - 964808
AB  - PURPOSE: Prolactin (PRL) exerts actions in the bone besides lactation and 
      reproduction. This study aimed to investigate whether PRL is related to bone 
      mineral density (BMD) in type 2 diabetes mellitus (T2DM). METHODS: A total of 642 
      patients with T2DM were divided into two groups with age and body mass index 
      (BMI) matched: mildly increased PRL (HP group, n = 101) or normal PRL (NP group, 
      n = 541). BMD was measured by dual-energy X-ray absorptiometry and compared. 
      RESULTS: 1) BMD, T score at lumbar spine L1-4, right hip and femur neck, and Z 
      score at the femur neck were significantly higher in the HP than in the NP group 
      (0.96 +/- 0.16 vs. 0.92 +/- 0.15g/cm(2), p = 0.019; 0.88 +/- 0.15vs. 0.84 +/- 0.14 
      g/cm(2), p = 0.007; 0.75 +/- 0.17 vs.0.70 +/- 0.13 g/cm(2), p = 0.001; -0.90 (-1.85, 
      -0.20) vs. -1.40 (-2.20, -0.40), p = 0.018; -0.80 (-1.50, -0.30) vs. -1.10 
      (-1.80, -0.53), p = 0.026; -1.30 (-2.00, -0.60) vs. -1.70 (-2.20, -1.00), p = 
      0.001; -0.20 (-0.70, 0.30) vs. -0.40 (-0.90, 0.10), p = 0.026). In men, T and Z 
      scores at the right hip and femur neck were significantly higher in the HP than 
      in the NP group (-0.70 (-1.32, 0.20) vs. -0.90 (-1.50, -0.40), p = 0.038; -0.20 
      (-0.80, 0.20) vs. -0.50 (-0.10, 0.10), p = 0.027; -0.30 (-0.60, -0.30) vs. -0.40 
      (-0.90, 0.20), p = 0.038) but not in women. Bone turnover markers have no 
      significant difference between groups (all p > 0.05). 2) BMD at the right hip and 
      Z score at the right hip and femur neck were significantly positively associated 
      with PRL (r = 0.087, p = 0.029; r = 0.089, p = 0.024; r = 0.087, p = 0.029). In 
      men, BMD at L1-4 and the right hip; T score at L1-4, the right hip, and the femur 
      neck; and Z score at the right hip and the femur neck were significantly 
      positively associated with PRL (r = 0.122, p = 0.007; r = 0.105, p = 0.041; r = 
      0.123, p = 0.016; r = 0.110, p = 0.032; r = 0.115, p = 0.025; r = 0.121, p = 
      0.018; r = 0.138, p = 0.007) but not significant in women. 3) In men divided into 
      two groups according to T score (T score at the right hip>-1 or T score at the 
      right hip</=-1) or the median BMD at L1-4, the right hip or the femur neck, PRL was 
      significantly higher in the higher BMD than in the lower BMD group (16.32 +/- 6.12 
      vs. 14.78 +/- 5.68 ng/ml, p = 0.012; 16.20 +/- 6.21 vs. 14.73 +/- 5.40 ng/ml, p = 
      0.014; 16.10 +/- 6.01 vs. 14.80 +/- 5.77 ng/ml, p = 0.032; 16.17 +/- 6.04 vs. 14.76 +/- 
      5.77 ng/ml, p = 0.02; 16.48 +/- 6.05 vs. 14.98 +/- 5.81 ng/ml, p = 0.020; 16.10 +/- 
      5.98 vs. 14.80 +/- 5.87 ng/ml, p = 0.035). CONCLUSION: Increased PRL was associated 
      with better BMD in patients with T2DM, especially in men. PRL within the 
      biologically normal range may play a protective role in the BMD of T2DM.
CI  - Copyright (c) 2022 Chen, Liu, Li and Deng.
FAU - Chen, Jia
AU  - Chen J
AD  - Department of Endocrinology, Beijing Jishuitan Hospital, Beijing, China.
FAU - Liu, Geng
AU  - Liu G
AD  - Department of Emergency, Beijing Jishuitan Hospital, Beijing, China.
FAU - Li, Quan
AU  - Li Q
AD  - Department of Endocrinology, Beijing Jishuitan Hospital, Beijing, China.
FAU - Deng, Wei
AU  - Deng W
AD  - Department of Endocrinology, Beijing Jishuitan Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221012
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 9002-62-4 (Prolactin)
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - *Bone Density
MH  - Prolactin
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Femur Neck/diagnostic imaging
MH  - Absorptiometry, Photon
PMC - PMC9596976
OTO - NOTNLM
OT  - bone mineral density
OT  - glucose
OT  - metabolism
OT  - prolactin
OT  - type 2 diabetes
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/01 06:00
MHDA- 2022/11/02 06:00
PMCR- 2022/01/01
CRDT- 2022/10/31 05:05
PHST- 2022/06/09 00:00 [received]
PHST- 2022/09/21 00:00 [accepted]
PHST- 2022/10/31 05:05 [entrez]
PHST- 2022/11/01 06:00 [pubmed]
PHST- 2022/11/02 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.964808 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Oct 12;13:964808. doi: 
      10.3389/fendo.2022.964808. eCollection 2022.