PMID- 36313890
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221102
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 10
DP  - 2022
TI  - Comparing outcomes between culture-positive and culture-negative septic shock in 
      a PICU: A retrospective cohort study.
PG  - 1001565
LID - 10.3389/fped.2022.1001565 [doi]
LID - 1001565
AB  - BACKGROUND: We assessed the outcomes and characteristics of culture-negative 
      septic shock (CNSS) and culture-positive septic shock (CPSS) in pediatric 
      intensive care unit (PICU). METHODS: We performed a retrospective study on the 
      data of children admitted to the PICU due to septic shock between January 2018 
      and December 2021. The primary outcome was in-hospital mortality. The secondary 
      outcomes were the length of stay (LOS) of hospital, the need for mechanical 
      ventilation (MV) and continue renal replacement therapy (CRRT). RESULTS: Overall, 
      238 patients were enrolled. 114 patients (47.9%) had positive cultures (60 blood 
      samples, 41 sputum samples, 17 pus samples, and 19 others), 18 of whom were 
      cultured positive at two sites, 1 at three sites, and 3 had two different types 
      of bacteria at same site. The in-hospital mortality was 47.1%. There were no 
      significant differences in the in-hospital mortality (47.6% vs. 46.5%, 
      P = 0.866), PRISM-III score (10 vs. 12, P = 0.409), PIM-3 score (0.08 vs. 0.07, 
      P = 0.845), pSOFA score (10 vs. 10, P = 0.677) or the need for MV (64.5% vs. 
      68.4%, P = 0.524) and CRRT (29.8% vs. 34.2%, P = 0.470) between the CNSS group 
      and the CPSS group. The Procalcitonin (8.89 ng/ml vs. 28.39 ng/ml, P = 0.001) and 
      C-reactive protein (28 mg/L vs. 58 mg/L, P = 0.001) levels were significantly 
      lower in the CNSS group than in the CPSS group, while WBC count (9.03 x 10(9)/L 
      vs. 5.02 x 10(9)/L, P = 0.002) and serum sodium (137 mmol/L vs. 132 mmol/L, 
      P = 0.001) was significantly higher in CNSS. The LOS of hospital was 
      significantly longer (16 days vs. 11 days, P = 0.011) in the CPSS group than in 
      the CNSS group, while the LOS of PICU (5 days vs. 4 days, P = 0.094) stay was not 
      significantly different. CONCLUSION: Compared with children with CNSS, children 
      with CPSS had higher PCT and CRP levels, but lower WBC count. Children with CPSS 
      had longer LOS of hospital. However, positive or negative culture results were 
      not associated with in-hospital mortality, the LOS of PICU, the need for MV or 
      CRRT in children with septic shock.
CI  - (c) 2022 Huang, Chen, Dang, Liu and Fu.
FAU - Huang, Haixin
AU  - Huang H
AD  - Department of Critical Care Medicine, Children's Hospital of Chongqing Medical 
      University, National Clinical Research Center for Child Health and Disorders, 
      Ministry of Education Key Laboratory of Child Development and Disorders, 
      Chongqing Key Laboratory of Pediatrics, Chongqing, China.
FAU - Chen, Jian
AU  - Chen J
AD  - Department of Critical Care Medicine, Children's Hospital of Chongqing Medical 
      University, National Clinical Research Center for Child Health and Disorders, 
      Ministry of Education Key Laboratory of Child Development and Disorders, 
      Chongqing Key Laboratory of Pediatrics, Chongqing, China.
FAU - Dang, Hongxing
AU  - Dang H
AD  - Department of Critical Care Medicine, Children's Hospital of Chongqing Medical 
      University, National Clinical Research Center for Child Health and Disorders, 
      Ministry of Education Key Laboratory of Child Development and Disorders, 
      Chongqing Key Laboratory of Pediatrics, Chongqing, China.
FAU - Liu, Chengjun
AU  - Liu C
AD  - Department of Critical Care Medicine, Children's Hospital of Chongqing Medical 
      University, National Clinical Research Center for Child Health and Disorders, 
      Ministry of Education Key Laboratory of Child Development and Disorders, 
      Chongqing Key Laboratory of Pediatrics, Chongqing, China.
FAU - Fu, Yue-Qiang
AU  - Fu YQ
AD  - Department of Critical Care Medicine, Children's Hospital of Chongqing Medical 
      University, National Clinical Research Center for Child Health and Disorders, 
      Ministry of Education Key Laboratory of Child Development and Disorders, 
      Chongqing Key Laboratory of Pediatrics, Chongqing, China.
LA  - eng
PT  - Journal Article
DEP - 20221013
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC9608626
OTO - NOTNLM
OT  - children
OT  - culture negative
OT  - culture positive
OT  - mortality
OT  - septic shock
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/11/01 06:00
MHDA- 2022/11/01 06:01
PMCR- 2022/10/13
CRDT- 2022/10/31 05:07
PHST- 2022/07/23 00:00 [received]
PHST- 2022/09/26 00:00 [accepted]
PHST- 2022/10/31 05:07 [entrez]
PHST- 2022/11/01 06:00 [pubmed]
PHST- 2022/11/01 06:01 [medline]
PHST- 2022/10/13 00:00 [pmc-release]
AID - 10.3389/fped.2022.1001565 [doi]
PST - epublish
SO  - Front Pediatr. 2022 Oct 13;10:1001565. doi: 10.3389/fped.2022.1001565. 
      eCollection 2022.