PMID- 36315075
OWN - NLM
STAT- MEDLINE
DCOM- 20230708
LR  - 20240320
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Linking)
VI  - 62
IP  - 7
DP  - 2023 Jul 5
TI  - COVID-19 vaccination in autoimmune diseases (COVAD) study: vaccine safety and 
      tolerance in rheumatoid arthritis.
PG  - 2366-2376
LID - 10.1093/rheumatology/keac624 [doi]
AB  - OBJECTIVES: The COVID-19 vaccination in autoimmune diseases (COVAD) study aimed 
      to assess short-term COVID-19 vaccination-related adverse events (AEs) in RA 
      patients. METHODS: An online self-reported questionnaire (March-December 2021) 
      was used to capture data related to COVID-19 vaccination-related AEs in RA, other 
      autoimmune rheumatic diseases (AIRDs) (excluding RA and inflammatory myositis), 
      non-rheumatic autoimmune diseases (nrAIDs) and healthy controls (HCs). 
      Descriptive and multivariable regression analyses were performed. RESULTS: Of the 
      9462 complete respondents, 14.2% (n = 1347) had been diagnosed with RA; they had 
      a mean (s.d.) age of 50.7 (13.7) years, 74.2% were women and 49.3% were 
      Caucasian. In total, 76.9% and 4.2% of patients with RA reported minor and major 
      AEs, respectively. Patients with active and inactive RA had similar AE and 
      hospitalization frequencies. Overall, AEs were reported more frequently by 
      BNT162b2 and mRNA-1273 recipients and less frequently by BBV152 recipients 
      compared with the rest. Major AE and hospitalization frequencies were similar 
      across recipients of different vaccines. Patients receiving methotrexate and 
      hydroxychloroquine reported fewer minor AEs than those patients not on them. 
      Compared with HCs and patients with other AIRDs, patients with RA reported 
      similar total AEs, overall minor AEs, and hospitalizations. Compared with nrAIDs, 
      patients with RA reported lower frequencies of overall AEs, minor AEs (both odds 
      ratio [OR] = 0.7; 95% CI: 0.5, 0.9), and injection site pain (OR = 0.6; 95% CI: 
      0.5, 0.8) with similar major AE and hospitalization frequencies. CONCLUSION: 
      Despite the differences in AE frequency across different COVID-19 vaccines, all 
      were well tolerated in patients with RA and were comparable to HCs, providing 
      reassurance as to the safety of COVID-19 vaccination.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the 
      British Society for Rheumatology. All rights reserved. For permissions, please 
      email: journals.permissions@oup.com.
FAU - Naveen, R
AU  - Naveen R
AUID- ORCID: 0000-0003-2014-3925
AD  - Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate 
      Institute of Medical Sciences, Lucknow, India.
FAU - Parodis, Ioannis
AU  - Parodis I
AUID- ORCID: 0000-0002-4875-5395
AD  - Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and 
      Karolinska University Hospital, Stockholm, Sweden.
AD  - Department of Rheumatology, Faculty of Medicine and Health, Orebro University, 
      Orebro, Sweden.
FAU - Joshi, Mrudula
AU  - Joshi M
AUID- ORCID: 0000-0001-7312-351X
AD  - Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, 
      Pune, India.
FAU - Sen, Parikshit
AU  - Sen P
AUID- ORCID: 0000-0002-1630-6026
AD  - Maulana Azad Medical College, New Delhi, India.
FAU - Lindblom, Julius
AU  - Lindblom J
AD  - Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and 
      Karolinska University Hospital, Stockholm, Sweden.
FAU - Agarwal, Vishwesh
AU  - Agarwal V
AUID- ORCID: 0000-0002-0986-8354
AD  - Mahatma Gandhi Mission Medical College, Navi Mumbai, Maharashtra, India.
FAU - Lilleker, James B
AU  - Lilleker JB
AUID- ORCID: 0000-0002-9230-4137
AD  - Centre for Musculoskeletal Research, Division of Musculoskeletal and 
      Dermatological Sciences, School of Biological Sciences, Faculty of Biology, 
      Medicine and Health, Manchester Academic Health Science Centre, The University of 
      Manchester, Manchester, UK.
AD  - Neurology, Manchester Centre for Clinical Neurosciences, Northern Care Alliance 
      NHS Foundation Trust, Salford, UK.
FAU - Tan, Ai Lyn
AU  - Tan AL
AUID- ORCID: 0000-0002-9158-7243
AD  - NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK.
AD  - Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 
      Leeds, UK.
FAU - Nune, Arvind
AU  - Nune A
AUID- ORCID: 0000-0002-3849-614X
AD  - Southport and Ormskirk Hospital NHS Trust, Southport, UK.
FAU - Shinjo, Samuel Katsuyuki
AU  - Shinjo SK
AUID- ORCID: 0000-0002-3682-4517
AD  - Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, 
      Sao Paulo, Brazil.
FAU - Salim, Babur
AU  - Salim B
AUID- ORCID: 0000-0001-8430-9299
AD  - Rheumatology Department, Fauji Foundation Hospital, Rawalpindi, Pakistan.
FAU - Ziade, Nelly
AU  - Ziade N
AUID- ORCID: 0000-0002-4479-7678
AD  - Rheumatology Department, Saint-Joseph University, Beirut, Lebanon.
AD  - Rheumatology Department, Hotel-Dieu de France Hospital, Beirut, Lebanon.
FAU - Velikova, Tsvetelina
AU  - Velikova T
AUID- ORCID: 0000-0002-0593-1272
AD  - Department of Clinical Immunology, Medical Faculty, University Hospital 
      'Lozenetz', Sofia University St. Kliment Ohridski, Sofia, Bulgaria.
FAU - Edgar Gracia-Ramos, Abraham
AU  - Edgar Gracia-Ramos A
AUID- ORCID: 0000-0003-1842-2554
AD  - Department of Internal Medicine, General Hospital, National Medical Center 'La 
      Raza', Instituto Mexicano del Seguro Social, Mexico City, Mexico.
FAU - Saavedra, Miguel A
AU  - Saavedra MA
AUID- ORCID: 0000-0003-0687-9944
AD  - Departamento de Reumatologia Hospital de Especialidades Dr. Antonio Fraga Mouret, 
      Centro Medico Nacional La Raza, IMSS, Mexico City, Mexico.
FAU - Day, Jessica
AU  - Day J
AUID- ORCID: 0000-0001-8528-4361
AD  - Department of Rheumatology, Royal Melbourne Hospital, Parkville, VIC, Australia.
AD  - Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
AD  - Department of Medical Biology, University of Melbourne, Parkville, VIC, 
      Australia.
FAU - Makol, Ashima
AU  - Makol A
AUID- ORCID: 0000-0002-8748-898X
AD  - Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.
FAU - Distler, Oliver
AU  - Distler O
AUID- ORCID: 0000-0002-0546-8310
AD  - Department of Rheumatology, University Hospital Zurich, University of Zurich, 
      Zurich, Switzerland.
FAU - Chinoy, Hector
AU  - Chinoy H
AUID- ORCID: 0000-0001-6492-1288
AD  - Centre for Musculoskeletal Research, Division of Musculoskeletal and 
      Dermatological Sciences, School of Biological Sciences, Faculty of Biology, 
      Medicine and Health, Manchester Academic Health Science Centre, The University of 
      Manchester, Manchester, UK.
AD  - National Institute for Health Research Manchester Biomedical Research Centre, 
      Manchester University NHS Foundation Trust, The University of Manchester, 
      Manchester, UK.
AD  - Department of Rheumatology, Salford Royal Hospital, Northern Care Alliance NHS 
      Foundation Trust, Salford, UK.
FAU - Agarwal, Vikas
AU  - Agarwal V
AUID- ORCID: 0000-0002-2089-027X
AD  - Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate 
      Institute of Medical Sciences, Lucknow, India.
FAU - Aggarwal, Rohit
AU  - Aggarwal R
AUID- ORCID: 0000-0001-7531-8038
AD  - Division of Rheumatology and Clinical Immunology, University of Pittsburgh School 
      of Medicine, Pittsburgh, PA, USA.
FAU - Gupta, Latika
AU  - Gupta L
AUID- ORCID: 0000-0003-2753-2990
AD  - Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust, 
      Wolverhampton, UK.
AD  - Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate 
      Institute of Medical Sciences, Lucknow, India.
AD  - City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
AD  - Centre for Musculoskeletal Research, Division of Musculoskeletal and 
      Dermatological Sciences, School of Biological Sciences, Faculty of Biology, 
      Medicine and Health, Manchester Academic Health Science Centre, The University of 
      Manchester, Manchester, UK.
FAU - Nikiphorou, Elena
AU  - Nikiphorou E
AUID- ORCID: 0000-0001-6847-3726
AD  - Centre for Rheumatic Diseases, King's College London, London, UK.
AD  - Rheumatology Department, King's College Hospital, London, UK.
CN  - COVAD Study Group
LA  - eng
GR  - 21992/VAC_/Versus Arthritis/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
RN  - 76JZE5DSN6 (BBV152 COVID-19 vaccine)
RN  - 0 (BNT162 Vaccine)
RN  - 0 (COVID-19 Vaccines)
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Arthritis, Rheumatoid/drug therapy
MH  - *Autoimmune Diseases/epidemiology
MH  - BNT162 Vaccine
MH  - *COVID-19/prevention & control
MH  - *COVID-19 Vaccines/adverse effects
MH  - *Rheumatic Diseases
MH  - Vaccination/adverse effects
OTO - NOTNLM
OT  - Adverse effects
OT  - COVID-19
OT  - RA
OT  - autoimmune diseases
OT  - vaccination
FIR - Barman, Bhupen
IR  - Barman B
FIR - Singh, Yogesh Preet
IR  - Singh YP
FIR - Ranjan, Rajiv
IR  - Ranjan R
FIR - Jain, Avinash
IR  - Jain A
FIR - Pandya, Sapan C
IR  - Pandya SC
FIR - Pilania, Rakesh Kumar
IR  - Pilania RK
FIR - Sharma, Aman
IR  - Sharma A
FIR - M, Manoj
IR  - M M
FIR - Gupta, Vikas
IR  - Gupta V
FIR - Kavadichanda, Chengappa G
IR  - Kavadichanda CG
FIR - Patro, Pradeepta Sekhar
IR  - Patro PS
FIR - Ajmani, Sajal
IR  - Ajmani S
FIR - Phatak, Sanat
IR  - Phatak S
FIR - Goswami, Rudra Prosad
IR  - Goswami RP
FIR - Chowdhury, Abhra Chandra
IR  - Chowdhury AC
FIR - Mathew, Ashish Jacob
IR  - Mathew AJ
FIR - Shenoy, Padnamabha
IR  - Shenoy P
FIR - Asranna, Ajay
IR  - Asranna A
FIR - Bommakanti, Keerthi Talari
IR  - Bommakanti KT
FIR - Shukla, Anuj
IR  - Shukla A
FIR - Pandey, Arun Kumar R
IR  - Pandey AKR
FIR - Chandwar, Kunal
IR  - Chandwar K
FIR - Kardes, Sinan
IR  - Kardes S
FIR - Cansu, Dondu Uskudar
IR  - Cansu DU
FIR - Kim, Minchul
IR  - Kim M
FIR - Makol, Ashima
IR  - Makol A
FIR - Chatterjee, Tulika
IR  - Chatterjee T
FIR - Pauling, John D
IR  - Pauling JD
FIR - Wincup, Chris
IR  - Wincup C
FIR - Cavagna, Lorenzo
IR  - Cavagna L
FIR - Del Papa, Nicoletta
IR  - Del Papa N
FIR - Sambataro, Gianluca
IR  - Sambataro G
FIR - Fabiola, Atzeni
IR  - Fabiola A
FIR - Govoni, Marcello
IR  - Govoni M
FIR - Parisi, Simone
IR  - Parisi S
FIR - Bocci, Elena Bartoloni
IR  - Bocci EB
FIR - Sebastiani, Gian Domenico
IR  - Sebastiani GD
FIR - Fusaro, Enrico
IR  - Fusaro E
FIR - Sebastiani, Marco
IR  - Sebastiani M
FIR - Quartuccio, Luca
IR  - Quartuccio L
FIR - Franceschini, Franco
IR  - Franceschini F
FIR - Sainaghi, Pier Paolo
IR  - Sainaghi PP
FIR - Orsolini, Giovanni
IR  - Orsolini G
FIR - De Angelis, Rossella
IR  - De Angelis R
FIR - Danielli, Maria Giovanna
IR  - Danielli MG
FIR - Venerito, Vincenzo
IR  - Venerito V
FIR - Milchert, Dr Marcin
IR  - Milchert DM
FIR - Traboco, Lisa S
IR  - Traboco LS
FIR - Wibowo, Suryo Anggoro Kusumo
IR  - Wibowo SAK
FIR - Tehozol, Erick Adrian Zamora
IR  - Tehozol EAZ
FIR - Serrano, Jorge Rojas
IR  - Serrano JR
FIR - De La Torre, Ignacio Garcia
IR  - De La Torre IG
FIR - Loarce-Martos, Jesus
IR  - Loarce-Martos J
FIR - Prieto-Gonzalez, Sergio
IR  - Prieto-Gonzalez S
FIR - Gil-Vila, Albert
IR  - Gil-Vila A
FIR - Gonzalez, Raquel Aranega
IR  - Gonzalez RA
FIR - Kuwana, Masataka
IR  - Kuwana M
FIR - Yoshida, Akira
IR  - Yoshida A
FIR - Nakashima, Ran
IR  - Nakashima R
FIR - Sato, Shinji
IR  - Sato S
FIR - Kimura, Naoki
IR  - Kimura N
FIR - Kaneko, Yuko
IR  - Kaneko Y
FIR - Knitza, Johannes
IR  - Knitza J
FIR - Tomaras, Stylianos
IR  - Tomaras S
FIR - Gromova, Margarita Aleksandrovna
IR  - Gromova MA
FIR - Aharonov, Or
IR  - Aharonov O
FIR - Gheita, Tamer A
IR  - Gheita TA
FIR - Hmamouchi, Ihsane
IR  - Hmamouchi I
FIR - Hoff, Leonardo Santos
IR  - Hoff LS
FIR - Giannini, Margherita
IR  - Giannini M
FIR - Maurier, Francois
IR  - Maurier F
FIR - Campagne, Julien
IR  - Campagne J
FIR - Meyer, Alain
IR  - Meyer A
FIR - Nagy-Vincze, Melinda
IR  - Nagy-Vincze M
FIR - Langguth, Daman
IR  - Langguth D
FIR - Limaye, Vidya
IR  - Limaye V
FIR - Needham, Merrilee
IR  - Needham M
FIR - Srivastav, Nilesh
IR  - Srivastav N
FIR - Hudson, Marie
IR  - Hudson M
FIR - Landon-Cardinal, Oceane
IR  - Landon-Cardinal O
FIR - Shaharir, Syahrul Sazliyana
IR  - Shaharir SS
FIR - Zuleta, Wilmer Gerardo Rojas
IR  - Zuleta WGR
FIR - Silva, Jose Antonio Pereira
IR  - Silva JAP
FIR - Fonseca, Joao Eurico
IR  - Fonseca JE
FIR - Zimba, Olena
IR  - Zimba O
EDAT- 2022/11/01 06:00
MHDA- 2023/07/07 06:42
CRDT- 2022/10/31 11:13
PHST- 2022/09/09 00:00 [received]
PHST- 2022/10/13 00:00 [accepted]
PHST- 2023/07/07 06:42 [medline]
PHST- 2022/11/01 06:00 [pubmed]
PHST- 2022/10/31 11:13 [entrez]
AID - 6782953 [pii]
AID - 10.1093/rheumatology/keac624 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2023 Jul 5;62(7):2366-2376. doi: 
      10.1093/rheumatology/keac624.