PMID- 36317119
OWN - NLM
STAT- MEDLINE
DCOM- 20230123
LR  - 20230123
IS  - 2167-8359 (Print)
IS  - 2167-8359 (Electronic)
IS  - 2167-8359 (Linking)
VI  - 10
DP  - 2022
TI  - A retrospective study of immunoglobulin E as a biomarker for the diagnosis of 
      acute ischemic stroke with carotid atherosclerotic plaques.
PG  - e14235
LID - 10.7717/peerj.14235 [doi]
LID - e14235
AB  - OBJECTIVE: In this study, serum markers of acute ischemic stroke (AICS) with 
      carotid artery plaque were retrospectively evaluated to establish a basis for 
      discovering serological indicators for early warning of acute ischemic stroke 
      (AICS). METHODS: A total of 248 patients with AICS were enrolled in Lanzhou 
      University Second Hospital from January 2019 to December 2020. The study 
      population included 136 males and 112 females, 64 +/- 11 years of age. Of these, 
      there were 90 patients with a transient ischemic attack (TIA), including 60 males 
      and 30 females, aged 64 +/- 8 years old. Patients with AICS were stratified by 
      carotid ultrasound into a plaque group (n = 154) and a non-plaque group (n = 94). 
      A total of 160 healthy subjects were selected as the control group. Serum 
      lipoprotein-associated phospholipase A2 (Lp-PLA2), amyloid A (SAA), 
      immunoglobulin E (IgE), D-dimer (D-D), total cholesterol (TC), triglyceride (TG), 
      and low-density lipoprotein cholesterol (LDL-C) were collected from all subjects. 
      Multivariate logistic regression was used to analyze the risk factors of AICS 
      with carotid plaque. ROC curve was used to analyze the diagnostic efficacy of 
      AICS with carotid plaque. RESULTS: The IgE, Lp-PLA2, SAA, LDL-C, TC, TG, and D-D 
      levels in the AICS group were higher than those in the TIA group and healthy 
      control group (P < 0.05). The IgE level was significantly higher than that in the 
      healthy control group and TIA group. The IgE level in the AICS plaque group was 
      significantly higher than that in the AICS non-plaque group (P < 0.01), and the 
      Lp-PLA2 level was also different (P < 0.05). The incidence of AICS was positively 
      correlated with Lp-PLA2, TC, IgE, TG, D-D, SAA and LDL-C (r = 0.611, 0.499, 
      0.478, 0.431, 0.386, 0.332, 0.280, all P < 0.05). The incidence of AICS with 
      plaque was only positively correlated with IgE and Lp-PLA2 (r = 0.588, 0.246, 
      P < 0.05). Logistic regression analysis showed that IgE and Lp-PLA2 were 
      independent risk factors for predicting the occurrence of AICS with carotid 
      plaque (P < 0.05). ROC curve analysis showed that the AUC of IgE (0.849) was 
      significantly higher than other indicators; its sensitivity and specificity were 
      also the highest, indicating that IgE can improve the diagnostic efficiency of 
      AICS with carotid plaque. CONCLUSION: IgE is a serum laboratory indicator used to 
      diagnose AICS disease with carotid plaque, which lays a foundation for further 
      research on potential early warning indicators of AICS disease.
CI  - (c)2022 Jiang et al.
FAU - Jiang, Wenwen
AU  - Jiang W
AD  - Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, Gansu 
      Province, China.
FAU - Niu, Jindou
AU  - Niu J
AD  - Department of Clinical Laboratory, Maternal and Child Health Hospital of Gansu 
      Province, Lanzhou, Gansu Province, China.
FAU - Gao, Hongwei
AU  - Gao H
AD  - Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, Gansu 
      Province, China.
FAU - Dang, Yingqiang
AU  - Dang Y
AD  - Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, Gansu 
      Province, China.
FAU - Qi, Meijiao
AU  - Qi M
AD  - Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, Gansu 
      Province, China.
FAU - Liu, Yumei
AU  - Liu Y
AD  - Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, Gansu 
      Province, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221026
PL  - United States
TA  - PeerJ
JT  - PeerJ
JID - 101603425
RN  - EC 3.1.1.47 (1-Alkyl-2-acetylglycerophosphocholine Esterase)
RN  - 0 (Cholesterol, LDL)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Biomarkers)
RN  - 0 (Serum Amyloid A Protein)
MH  - Male
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - *Plaque, Atherosclerotic/diagnosis
MH  - Retrospective Studies
MH  - *Atherosclerosis
MH  - 1-Alkyl-2-acetylglycerophosphocholine Esterase
MH  - *Ischemic Stroke/diagnosis
MH  - Cholesterol, LDL
MH  - Immunoglobulin E
MH  - *Ischemic Attack, Transient
MH  - Biomarkers
MH  - Serum Amyloid A Protein
PMC - PMC9617546
OTO - NOTNLM
OT  - Acute ischemic stroke
OT  - Carotid plaque
OT  - Diagnostic performance
OT  - Immunoglobulin E
OT  - Laboratory indicator
COIS- The authors declare there are no competing interests.
EDAT- 2022/11/02 06:00
MHDA- 2022/11/02 06:01
PMCR- 2022/10/26
CRDT- 2022/11/01 01:48
PHST- 2022/05/12 00:00 [received]
PHST- 2022/09/22 00:00 [accepted]
PHST- 2022/11/01 01:48 [entrez]
PHST- 2022/11/02 06:00 [pubmed]
PHST- 2022/11/02 06:01 [medline]
PHST- 2022/10/26 00:00 [pmc-release]
AID - 14235 [pii]
AID - 10.7717/peerj.14235 [doi]
PST - epublish
SO  - PeerJ. 2022 Oct 26;10:e14235. doi: 10.7717/peerj.14235. eCollection 2022.