PMID- 36318486
OWN - NLM
STAT- MEDLINE
DCOM- 20221222
LR  - 20221229
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Linking)
VI  - 20
IP  - 10
DP  - 2022 Dec
TI  - Effect of Fiber Supplementation on Systemic Inflammation and Liver Steatosis in 
      Mice Fed with High-Carbohydrate Diets.
PG  - 558-566
LID - 10.1089/met.2022.0047 [doi]
AB  - Background: High consumption of carbohydrates can trigger metabolic and 
      inflammatory disorders in the body. Thus, the aim of this study was to evaluate 
      the effect of fiber supplementation on inflammation and hepatic steatosis in mice 
      fed high-carbohydrate diets. Methods: Swiss male mice were distributed into two 
      control groups and two experimental groups that received isocaloric diet rich in 
      starch (55%) or rich in fructose (55%). In the last 4 weeks of the experiment, 
      the animals received 5% fructo-oligosaccharide (FOS) supplementation via gavage, 
      or water in the control groups. After 16 weeks, biochemical analyses, 
      inflammatory cytokines, and histology of the liver of the animals were performed. 
      Results: The animals that received fructose had higher weight at the end of the 
      experiment as well as liver weight, consumed more feed, had higher levels of 
      tumor necrosis factor (TNF) and monocyte chemoattractant protein-1 (MCP-1), and a 
      higher degree of hepatic steatosis when compared with the animals that received 
      starch. However, the animals that received starch showed a higher inflammatory 
      process. FOS supplementation was efficient in reducing liver weight and hepatic 
      steatosis degree in animals fed with fructose diet but showed more degeneration 
      of liver tissue and high levels of inflammatory cytokines. FOS reduced the levels 
      of urea and total cholesterol in the starch-fed animals. Conclusions: Diets rich 
      in carbohydrates such as starch and fructose cause deleterious effects in 
      animals, and fiber supplementation can bring beneficial effects.
FAU - Hildebrand Budke, Cacilda Rocha
AU  - Hildebrand Budke CR
AUID- ORCID: 0000-0002-5319-8343
AD  - Faculdade de Medicina (FAMED), Universidade Federal de Mato Grosso do Sul/UFMS, 
      Campo Grande, Brazil.
FAU - Thomaz, Debora Marchetti Chaves
AU  - Thomaz DMC
AD  - Faculdade de Medicina (FAMED), Universidade Federal de Mato Grosso do Sul/UFMS, 
      Campo Grande, Brazil.
FAU - Oliveira, Rodrigo Juliano de
AU  - Oliveira RJ
AD  - Faculdade de Medicina (FAMED), Universidade Federal de Mato Grosso do Sul/UFMS, 
      Campo Grande, Brazil.
FAU - Guimaraes, Rita de Cassia Avellaneda
AU  - Guimaraes RCA
AD  - Faculdade de Medicina (FAMED), Universidade Federal de Mato Grosso do Sul/UFMS, 
      Campo Grande, Brazil.
FAU - Ramires, Amariles Diniz
AU  - Ramires AD
AD  - Faculdade de Medicina (FAMED), Universidade Federal de Mato Grosso do Sul/UFMS, 
      Campo Grande, Brazil.
FAU - Dourado, Doroty Mesquita
AU  - Dourado DM
AD  - Histologia, Universidade para o Desenvolvimento do Estado e Regiao do 
      Pantanal/Uniderp, Campo Grande, Brazil.
FAU - Santos, Elisvania Freitas Dos
AU  - Santos EFD
AD  - Faculdade de Medicina (FAMED), Universidade Federal de Mato Grosso do Sul/UFMS, 
      Campo Grande, Brazil.
FAU - Menezes, Adriana Conceicon Guercio
AU  - Menezes ACG
AD  - Faculdade de Medicina (FAMED), Universidade Federal de Mato Grosso do Sul/UFMS, 
      Campo Grande, Brazil.
FAU - Antoniolli-Silva, Andreia Conceicao Milan Brochado
AU  - Antoniolli-Silva ACMB
AD  - Faculdade de Medicina (FAMED), Universidade Federal de Mato Grosso do Sul/UFMS, 
      Campo Grande, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20221031
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
RN  - 0 (Dietary Carbohydrates)
RN  - 9005-25-8 (Starch)
RN  - 30237-26-4 (Fructose)
SB  - IM
MH  - Mice
MH  - Male
MH  - Animals
MH  - *Dietary Carbohydrates/adverse effects
MH  - *Fatty Liver/prevention & control
MH  - Liver/metabolism
MH  - Inflammation/complications
MH  - Starch/metabolism
MH  - Diet
MH  - Dietary Supplements
MH  - Fructose/adverse effects/metabolism
OTO - NOTNLM
OT  - fructo-oligosaccharide
OT  - fructose
OT  - inflammatory cytokines
OT  - prebiotics
OT  - starch
EDAT- 2022/11/02 06:00
MHDA- 2022/12/23 06:00
CRDT- 2022/11/01 13:02
PHST- 2022/11/02 06:00 [pubmed]
PHST- 2022/12/23 06:00 [medline]
PHST- 2022/11/01 13:02 [entrez]
AID - 10.1089/met.2022.0047 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2022 Dec;20(10):558-566. doi: 10.1089/met.2022.0047. 
      Epub 2022 Oct 31.