PMID- 36318919
OWN - NLM
STAT- MEDLINE
DCOM- 20230222
LR  - 20230222
IS  - 1836-7399 (Electronic)
IS  - 1448-7527 (Linking)
VI  - 29
IP  - 1
DP  - 2023 Feb
TI  - Partial meal replacement for people with type 2 diabetes: 2-year outcomes from an 
      Australian general practice.
PG  - 74-80
LID - 10.1071/PY22180 [doi]
AB  - BACKGROUND: This study aimed to determine weight loss and improvement in 
      glycaemia at 12 and 24months in patients with type 2 diabetes mellitus (T2DM), 
      following a 3-month partial meal replacement and subsequent reduced calorie diet. 
      METHODS: This was a retrospective cohort study of patients with T2DM attending a 
      solo general practice in Sydney, New South Wales, Australia. Participants were 
      advised to follow a 3-month partial meal replacement plan comprising of two meal 
      replacement shakes plus a healthy meal. Over the subsequent 21months, patients 
      were encouraged to follow a reduced calorie diet with a particular emphasis on 
      lowering carbohydrate intake. RESULTS: Of the 153 patients with T2DM, 51 (33.3%) 
      agreed to follow a 3-month partial meal replacement plan, which was completed by 
      66.7% (n =34/51). Compared to baseline, the average weight loss at 12 and 
      24months was 7.1+/-7.0kg (102.2+/-20.9kg vs 95.1+/-18.7kg, P <0.001) and 4.2+/-7.7kg 
      (102.2+/-20.9kg vs 98.0+/-18.2kg, P =0.003), respectively. Haemoglobin A1c (HbA1c) 
      was significantly reduced at 12months (6.9+/-1.5% vs 6.3+/-0.9%, P =0.003), but not 
      at 24months. The proportion of participants that met the criteria for diabetes 
      remission was similar at baseline (8.8%) and 12months (11.8%), but increased to 
      32.4% at 24months (P =0.016). CONCLUSIONS: Patients with T2DM who were able to 
      follow a partial meal replacement plan for 3months with advice from a general 
      practitioner achieved significant weight loss over 24months. A multicentre 
      randomised controlled trial to confirm these findings is required as this could 
      significantly change the management of T2DM in primary care.
FAU - Khoo, Chee L
AU  - Khoo CL
AD  - Healthfocus Family Practice, Ingleburn, NSW 2565, Australia; and School of 
      Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia.
FAU - Chimoriya, Ritesh
AU  - Chimoriya R
AD  - School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia.
FAU - Simmons, David
AU  - Simmons D
AD  - School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia; 
      and Macarthur Diabetes Endocrinology and Metabolism Service, Camden and 
      Campbelltown Hospitals, Campbelltown, NSW 2560, Australia.
FAU - Piya, Milan K
AU  - Piya MK
AD  - School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia; 
      and Macarthur Diabetes Endocrinology and Metabolism Service, Camden and 
      Campbelltown Hospitals, Campbelltown, NSW 2560, Australia.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust J Prim Health
JT  - Australian journal of primary health
JID - 101123037
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/therapy
MH  - Retrospective Studies
MH  - Australia
MH  - Weight Loss
MH  - Family Practice
EDAT- 2022/11/02 06:00
MHDA- 2023/02/22 06:00
CRDT- 2022/11/01 19:43
PHST- 2022/08/17 00:00 [received]
PHST- 2022/10/07 00:00 [accepted]
PHST- 2022/11/02 06:00 [pubmed]
PHST- 2023/02/22 06:00 [medline]
PHST- 2022/11/01 19:43 [entrez]
AID - PY22180 [pii]
AID - 10.1071/PY22180 [doi]
PST - ppublish
SO  - Aust J Prim Health. 2023 Feb;29(1):74-80. doi: 10.1071/PY22180.