PMID- 36319811
OWN - NLM
STAT- MEDLINE
DCOM- 20221103
LR  - 20221229
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Nov 1
TI  - BMI variability and incident diabetes mellitus, Tehran Lipid and Glucose 
      Study (TLGS).
PG  - 18370
LID - 10.1038/s41598-022-22817-6 [doi]
LID - 18370
AB  - Previous epidemiologic studies debated the association of body mass index (BMI) 
      trends with cardiovascular disease and mortality. This study aimed to evaluate 
      the association of BMI variability and slope with the incidence of Type 2 
      diabetes mellitus (T2DM) in a sex-stratified 15.8-year follow-up in the 
      population-based Tehran Lipid and Glucose Study (TLGS). Of 10,911 individuals 
      aged 20-60 years, 4981 subjects were included and followed for 15.8-years. The 
      slope coefficient of BMI in the linear regression model represented individuals' 
      BMI trends up to the incidence of DM. The root mean squared error (RMSE) of the 
      BMI linear trend was selected to reflect BMI variability through six follow-ups. 
      Cox proportional hazards regression was used to investigate the association of 
      the baseline BMI, BMI slope and RMSE with the incidence of T2DM among men and 
      women. Multivariable-adjusted HRs of T2DM for each SD increment in BMI slope was 
      1.18 (95% CI: 0.94-1.48, p = 0.161) in normal weight men and 1.26 (95% CI: 
      1.10-1.44, p = 0.001) in overweight and obese men. However, in women, each SD 
      increment in BMI slope increased the risk of T2DM with a HR of 1.19 (95% CI: 
      1.01-1.40, p = 0.039) in normal weight, and 1.14 (95% CI: 1.08-1.19, p < 0.001) 
      in women with BMI >/= 25 kg/m(2). In men with a baseline BMI >/= 25 kg/m(2), BMI-RMSE 
      was associated with a decreased risk of T2DM (HR: 0.71, 95% CI: 0.53-0.93, 
      p = 0.015). Baseline BMI was not associated with the risk of diabetes in men and 
      women. Positive BMI slope is associated with the development of diabetes in both 
      sexes. The association of BMI variability with incident T2DM differs according to 
      sex and baseline BMI. BMI variability is associated with a lower risk of T2DM in 
      overweight and obese men. BMI variability in women and baseline BMI in both 
      gender are not related to the risk of T2DM.
CI  - (c) 2022. The Author(s).
FAU - Mehran, Ladan
AU  - Mehran L
AD  - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid 
      Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
FAU - Mousapour, Pouria
AU  - Mousapour P
AD  - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid 
      Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
FAU - Khalili, Davood
AU  - Khalili D
AD  - Prevention of Metabolic Disorders Research Center, Research Institute for 
      Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 
      Islamic Republic of Iran.
AD  - Department of Biostatistics and Epidemiology, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic 
      Republic of Iran.
FAU - Cheraghi, Leila
AU  - Cheraghi L
AD  - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid 
      Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
FAU - Honarvar, Mohammadjavad
AU  - Honarvar M
AD  - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid 
      Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
FAU - Amouzegar, Atieh
AU  - Amouzegar A
AD  - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid 
      Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. 
      amouzegar@endocrine.ac.ir.
FAU - Azizi, Fereidoun
AU  - Azizi F
AD  - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid 
      Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221101
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Lipids)
SB  - IM
MH  - Male
MH  - Female
MH  - Humans
MH  - Body Mass Index
MH  - *Overweight/epidemiology
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Glucose
MH  - Risk Factors
MH  - Iran
MH  - Obesity/complications
MH  - Incidence
MH  - Lipids
PMC - PMC9626493
COIS- The authors declare no competing interests.
EDAT- 2022/11/03 06:00
MHDA- 2022/11/04 06:00
PMCR- 2022/11/01
CRDT- 2022/11/02 00:33
PHST- 2022/06/08 00:00 [received]
PHST- 2022/10/19 00:00 [accepted]
PHST- 2022/11/02 00:33 [entrez]
PHST- 2022/11/03 06:00 [pubmed]
PHST- 2022/11/04 06:00 [medline]
PHST- 2022/11/01 00:00 [pmc-release]
AID - 10.1038/s41598-022-22817-6 [pii]
AID - 22817 [pii]
AID - 10.1038/s41598-022-22817-6 [doi]
PST - epublish
SO  - Sci Rep. 2022 Nov 1;12(1):18370. doi: 10.1038/s41598-022-22817-6.