PMID- 36321694
OWN - NLM
STAT- MEDLINE
DCOM- 20230215
LR  - 20230215
IS  - 1522-7278 (Electronic)
IS  - 1520-4081 (Linking)
VI  - 38
IP  - 2
DP  - 2023 Feb
TI  - 1alpha,25-dihydroxyvitamin D(3) supplementation alleviates perfluorooctanesulfonate 
      acid-induced reproductive injury in male mice: Modulation of Nrf2 mediated 
      oxidative stress response.
PG  - 322-331
LID - 10.1002/tox.23685 [doi]
AB  - Perfluorooctanesulfonate acid (PFOS) is a typical persistent organic pollutant 
      that widely exists in the environment. To clarify the toxic effects and 
      mechanisms of PFOS and to find effective intervention strategies have been 
      attracted global attention. Here, we investigated the effects of PFOS on the male 
      reproductive system and explored the potential protective role of 
      1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2) D(3) ). Our results showed that 
      1alpha,25(OH)(2) D(3) intervention significantly improved PFOS-induced sperm quality 
      decline and testicular damage. Moreover, 1alpha,25(OH)(2) D(3) aggrandized the total 
      antioxidant capacity. Furthermore, after PFOS exposure, the transcription factor 
      nuclear factor erythroid-related factor 2 (Nrf2) was adaptively increased 
      together with its target genes, such as HO-1, NQO1, and SOD2. Meanwhile, 
      1alpha,25(OH)(2) D(3) ameliorated PFOS-induced augment of Nrf2 and target genes. 
      These findings indicated that 1alpha,25(OH)(2) D(3) might attenuate PFOS-induced 
      reproductive injury in male mice via Nrf2-mediated oxidative stress.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Liang, Yongchao
AU  - Liang Y
AUID- ORCID: 0000-0002-8116-3383
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Medical College of Soochow University, Suzhou, China.
FAU - Lu, Jingjing
AU  - Lu J
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Medical College of Soochow University, Suzhou, China.
FAU - Yi, Wenjie
AU  - Yi W
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Medical College of Soochow University, Suzhou, China.
FAU - Cai, Ming
AU  - Cai M
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Medical College of Soochow University, Suzhou, China.
FAU - Shi, Weiqiang
AU  - Shi W
AD  - Department of Pathology, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Li, Bingyan
AU  - Li B
AD  - Department of Nutrition and Food Hygiene, Medical College of Soochow University, 
      Suzhou, China.
FAU - Zhang, Zengli
AU  - Zhang Z
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Medical College of Soochow University, Suzhou, China.
FAU - Jiang, Fei
AU  - Jiang F
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Medical College of Soochow University, Suzhou, China.
LA  - eng
GR  - KYCX21_2984/Jiangsu Province Graduate Scientific Research Innovation Project/
GR  - SJCX21_1355/Jiangsu Province Graduate Student Practice Innovation Project/
GR  - 81703209/National Natural Science Foundation of China/
GR  - Priority Academic Program Development to Jiangsu Higher Education Institutions 
      (PAPD)/
PT  - Journal Article
DEP - 20221102
PL  - United States
TA  - Environ Toxicol
JT  - Environmental toxicology
JID - 100885357
RN  - 66772-14-3 (1,25-dihydroxyvitamin D)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
RN  - 1406-16-2 (Vitamin D)
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Animals
MH  - Male
MH  - Mice
MH  - Dietary Supplements
MH  - *NF-E2-Related Factor 2/metabolism
MH  - *Oxidative Stress
MH  - Semen/metabolism
MH  - *Vitamin D/pharmacology
MH  - *Testis/pathology
MH  - Alkanesulfonic Acids/toxicity
MH  - Fluorocarbons/toxicity
OTO - NOTNLM
OT  - 1alpha,25(OH)2D3
OT  - Nrf2
OT  - oxidative stress
OT  - perfluorooctanesulfonate acid
OT  - reproductive toxicity
EDAT- 2022/11/03 06:00
MHDA- 2023/01/18 06:00
CRDT- 2022/11/02 07:53
PHST- 2022/09/30 00:00 [revised]
PHST- 2022/03/25 00:00 [received]
PHST- 2022/10/13 00:00 [accepted]
PHST- 2022/11/03 06:00 [pubmed]
PHST- 2023/01/18 06:00 [medline]
PHST- 2022/11/02 07:53 [entrez]
AID - 10.1002/tox.23685 [doi]
PST - ppublish
SO  - Environ Toxicol. 2023 Feb;38(2):322-331. doi: 10.1002/tox.23685. Epub 2022 Nov 2.