PMID- 36322354
OWN - NLM
STAT- MEDLINE
DCOM- 20230224
LR  - 20230224
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 9
DP  - 2023 Feb
TI  - Associations of single and multiple organophosphate pesticide exposure with 
      female infertility in the USA: data from the 2015-2018 National Health and 
      Nutrition Examination Survey.
PG  - 23411-23421
LID - 10.1007/s11356-022-23624-2 [doi]
AB  - Substantial evidence has shown that organophosphate pesticide (OPP) exposure 
      altered the reproductive system functions, such as prolonged menstrual cycles, 
      sexual hormone imbalance, and changes in ovarian weight. However, the association 
      of OPP exposure with female infertility is unclear. We explored the relationships 
      of four single OPP metabolites and their mixed exposure with self-reported 
      infertility among women aged 20-50 in the USA using the data from two cycles 
      (2015-2016 and 2017-2018) of the National Health and Nutrition Examination Survey 
      (NHANES) by multiple logistic regression, Bayesian kernel machine regression 
      (BKMR), and quantile g-computation (QGC). Eventually, 659 females were included 
      in our study. Among these females, 77 participants were ever infertile. Multiple 
      logistic regression showed that the odds ratios (ORs) in the second and third 
      tertiles of dimethylphosphate (DMP) for female infertility were 2.53 (95% 
      confidence interval (95%CI): 1.20-5.32, P value = 0.016) and 2.96 (95%CI: 
      1.18-7.47, P value = 0.023) compared to the lowest tertile after adjusting for 
      all covariates (P for trend = 0.022). A significantly positive association 
      between the mixed OPP metabolites and infertility was observed in the BKMR model, 
      in which DMP had the highest posterior inclusion probability (PIP = 0.741). The 
      QGC model showed similar results, in which OPP metabolite mixtures increased the 
      risk of female infertility, with DMP as a significantly positive contributor to 
      the outcome. This study revealed the potential harm of OPP mixtures for female 
      infertility in the USA, and DMP played the most critical role in female 
      infertility risk among all OPP metabolites.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Wu, Yingying
AU  - Wu Y
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Weng, Xueqiong
AU  - Weng X
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Liu, Shan
AU  - Liu S
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Tan, Yuxuan
AU  - Tan Y
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Liang, Huanzhu
AU  - Liang H
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Li, Yexin
AU  - Li Y
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Wen, Lin
AU  - Wen L
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Chen, Qian
AU  - Chen Q
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China.
FAU - Jing, Chunxia
AU  - Jing C
AUID- ORCID: 0000-0001-7333-4181
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, 510632, Guangdong, China. 
      jcxphd@gmail.com.
AD  - Guangdong Key Laboratory of Environmental Exposure and Health, Jinan University, 
      Guangzhou, 510632, Guangdong, China. jcxphd@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20221102
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Pesticides)
RN  - 0 (Organophosphates)
SB  - IM
MH  - Humans
MH  - Female
MH  - United States
MH  - Nutrition Surveys
MH  - *Infertility, Female
MH  - Bayes Theorem
MH  - *Pesticides
MH  - Organophosphates
OTO - NOTNLM
OT  - Association
OT  - Bayesian kernel machine regression (BKMR)
OT  - Infertility
OT  - NHANES
OT  - Organophosphate pesticide
OT  - Quantile g-computation (QGC)
EDAT- 2022/11/03 06:00
MHDA- 2023/02/25 06:00
CRDT- 2022/11/02 12:21
PHST- 2022/07/07 00:00 [received]
PHST- 2022/10/10 00:00 [accepted]
PHST- 2022/11/03 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2022/11/02 12:21 [entrez]
AID - 10.1007/s11356-022-23624-2 [pii]
AID - 10.1007/s11356-022-23624-2 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Feb;30(9):23411-23421. doi: 
      10.1007/s11356-022-23624-2. Epub 2022 Nov 2.