PMID- 36323709
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221108
IS  - 2057-3995 (Electronic)
IS  - 2057-3995 (Linking)
VI  - 7
IP  - 1
DP  - 2022 Nov 3
TI  - ROS-responsive PPGF nanofiber membrane as a drug delivery system for long-term 
      drug release in attenuation of osteoarthritis.
PG  - 66
LID - 10.1038/s41536-022-00254-3 [doi]
LID - 66
AB  - Excessive reactive oxygen species (ROS) are one of the leading mechanisms in the 
      initiation and development of osteoarthritis (OA). However, conventional 
      injection of ROS-responsive drug delivery systems (DDSs) such as nanoparticles 
      and hydrogels usually cannot provide effective treatment due to rapid clearance 
      and degradation or low bioavailability. In this study, a ROS-responsive nanofiber 
      membrane named PLA/PEGDA-EDT@rGO-Fucoxanthin (PPGF) is fabricated by 
      electrospinning, wherein PEGDA-EDT served as the ROS-responsive motif, reduced 
      graphene oxide (rGO) as the drug carrier and fucoxanthin (Fx) as the 
      antioxidative and anti-inflammatory agent. The results demonstrated that the PPGF 
      nanofiber membrane exhibited sustained and long-term Fx release behavior (at 
      least 66 days) in response to hydrogen peroxide (H(2)O(2)) in vitro. With low 
      cytotoxicity and smart ROS responsiveness, PPGF showed excellent 
      anti-inflammatory and antioxidative effects on IL-1beta-induced chondrocytes by 
      potent ROS scavenging potential and upregulation of antioxidative enzymes. It 
      also demonstrated the attenuation of OA progression with the reduced 
      Osteoarthritis Research Society International (OARSI) score by 93.17% in 8 weeks. 
      The smart ROS-responsive, biodegradable and biocompatible nanofiber membranes 
      possess great potential for OA therapy under arthroscopy.
CI  - (c) 2022. The Author(s).
FAU - Wu, Jianjun
AU  - Wu J
AD  - Guangxi Engineering Center in Biomedical Materials for Tissue and Organ 
      Regeneration, The First Affiliated Hospital of Guangxi Medical University, 
      Nanning, 530021, P.R. China.
AD  - Guangxi Collaborative Innovation Center for Biomedicine, The First Affiliated 
      Hospital of Guangxi Medical University, Nanning, 530021, P.R. China.
FAU - Qin, Zainen
AU  - Qin Z
AD  - Guangxi Engineering Center in Biomedical Materials for Tissue and Organ 
      Regeneration, The First Affiliated Hospital of Guangxi Medical University, 
      Nanning, 530021, P.R. China.
AD  - Guangxi Collaborative Innovation Center for Biomedicine, The First Affiliated 
      Hospital of Guangxi Medical University, Nanning, 530021, P.R. China.
FAU - Jiang, Xianfang
AU  - Jiang X
AD  - Department of Oral Radiology, Guangxi Medical University College of Stomatology, 
      Nanning, 530021, P.R. China.
FAU - Fang, Depeng
AU  - Fang D
AD  - Guangxi Engineering Center in Biomedical Materials for Tissue and Organ 
      Regeneration, The First Affiliated Hospital of Guangxi Medical University, 
      Nanning, 530021, P.R. China.
AD  - Guangxi Collaborative Innovation Center for Biomedicine, The First Affiliated 
      Hospital of Guangxi Medical University, Nanning, 530021, P.R. China.
FAU - Lu, Zhenhui
AU  - Lu Z
AUID- ORCID: 0000-0001-8541-0700
AD  - Guangxi Engineering Center in Biomedical Materials for Tissue and Organ 
      Regeneration, The First Affiliated Hospital of Guangxi Medical University, 
      Nanning, 530021, P.R. China. Zhenhuilu1989@163.com.
AD  - Guangxi Collaborative Innovation Center for Biomedicine, The First Affiliated 
      Hospital of Guangxi Medical University, Nanning, 530021, P.R. China. 
      Zhenhuilu1989@163.com.
FAU - Zheng, Li
AU  - Zheng L
AD  - Guangxi Engineering Center in Biomedical Materials for Tissue and Organ 
      Regeneration, The First Affiliated Hospital of Guangxi Medical University, 
      Nanning, 530021, P.R. China. zhengli224@163.com.
AD  - Guangxi Collaborative Innovation Center for Biomedicine, The First Affiliated 
      Hospital of Guangxi Medical University, Nanning, 530021, P.R. China. 
      zhengli224@163.com.
FAU - Zhao, Jinmin
AU  - Zhao J
AD  - Guangxi Engineering Center in Biomedical Materials for Tissue and Organ 
      Regeneration, The First Affiliated Hospital of Guangxi Medical University, 
      Nanning, 530021, P.R. China. zhaojinmin@126.com.
AD  - Guangxi Collaborative Innovation Center for Biomedicine, The First Affiliated 
      Hospital of Guangxi Medical University, Nanning, 530021, P.R. China. 
      zhaojinmin@126.com.
AD  - Department of Orthopedics Trauma and Hand Surgery, The First Affiliated Hospital 
      of Guangxi Medical University, Nanning, 530021, P.R. China. zhaojinmin@126.com.
AD  - Guangxi Key Liboratory of Regenerative Medicine, The First Affiliated Hospital of 
      Guangxi Medical University, Nanning, 530021, China. zhaojinmin@126.com.
LA  - eng
PT  - Journal Article
DEP - 20221103
PL  - United States
TA  - NPJ Regen Med
JT  - NPJ Regenerative medicine
JID - 101699846
PMC - PMC9630282
COIS- The authors declare no competing interests.
EDAT- 2022/11/04 06:00
MHDA- 2022/11/04 06:01
PMCR- 2022/11/03
CRDT- 2022/11/03 00:21
PHST- 2022/02/19 00:00 [received]
PHST- 2022/09/12 00:00 [accepted]
PHST- 2022/11/03 00:21 [entrez]
PHST- 2022/11/04 06:00 [pubmed]
PHST- 2022/11/04 06:01 [medline]
PHST- 2022/11/03 00:00 [pmc-release]
AID - 10.1038/s41536-022-00254-3 [pii]
AID - 254 [pii]
AID - 10.1038/s41536-022-00254-3 [doi]
PST - epublish
SO  - NPJ Regen Med. 2022 Nov 3;7(1):66. doi: 10.1038/s41536-022-00254-3.