PMID- 36325161
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221104
IS  - 2667-1743 (Electronic)
IS  - 2667-1743 (Linking)
VI  - 2
IP  - 2
DP  - 2022 Apr
TI  - Structural Brain Volumes of Individuals at Clinical High Risk for Psychosis: A 
      Meta-analysis.
PG  - 147-152
LID - 10.1016/j.bpsgos.2021.09.002 [doi]
AB  - BACKGROUND: Structural magnetic resonance imaging studies in individuals at 
      clinical high risk (CHR) for psychosis have yielded conflicting results. METHODS: 
      The aims of this study were to compare intracranial and structural brain volumes 
      and variability of CHR individuals with those of healthy control (HC) subjects 
      and to investigate brain volume differences and variability in CHR subjects with 
      and without transition to psychosis. The PubMed and Embase databases were 
      searched for relevant studies published before June 1, 2020. RESULTS: A total of 
      34 studies were deemed eligible, which included baseline data of 2111 CHR and 
      1472 HC participants. In addition, data were included for 401 CHR subjects who 
      subsequently transitioned to psychosis and 1023 nontransitioned CHR participants. 
      Whole-brain and left, right, and bilateral hippocampal volume were significantly 
      smaller in CHR subjects than in HC subjects. Cerebrospinal fluid and lateral 
      ventricle volumes were significantly larger in CHR subjects than in HC subjects. 
      Variability was not significantly different in CHR subjects compared with HC 
      subjects. CHR individuals with and without subsequent transition to psychosis did 
      not show significant differences in any of the volumetric assessments or in 
      variability. CONCLUSIONS: This meta-analysis demonstrates reduced whole-brain and 
      hippocampal volumes and increased cerebrospinal fluid and lateral ventricle 
      volumes in CHR individuals. However, no significant differences were observed in 
      any of the volumetric assessments between CHR individuals with and without 
      subsequent transition to psychosis. These findings suggest that although 
      structural brain alterations are present before the onset of the disorder, they 
      may not significantly contribute to the identification of CHR individuals at the 
      highest risk for the development of psychosis.
CI  - (c) 2021 The Authors.
FAU - Vissink, Conrad E
AU  - Vissink CE
AD  - Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht 
      University, Utrecht, The Netherlands.
FAU - Winter-van Rossum, Inge
AU  - Winter-van Rossum I
AD  - Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht 
      University, Utrecht, The Netherlands.
FAU - Cannon, Tyrone D
AU  - Cannon TD
AD  - Departments of Psychology and Psychiatry, Yale University, New Haven, 
      Connecticut.
FAU - Fusar-Poli, Paolo
AU  - Fusar-Poli P
AD  - Early Psychosis: Interventions and Clinical-detection Laboratory, Department of 
      Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's 
      College London, London, United Kingdom.
AD  - OASIS Service, South London and Maudsley NHS Foundation Trust, London, United 
      Kingdom.
AD  - National Institute for Health Research, Maudsley Biomedical Research Centre, 
      South London and Maudsley NHS Foundation Trust, London, United Kingdom.
AD  - Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
FAU - Kahn, Rene S
AU  - Kahn RS
AD  - Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht 
      University, Utrecht, The Netherlands.
AD  - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New 
      York.
FAU - Bossong, Matthijs G
AU  - Bossong MG
AD  - Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht 
      University, Utrecht, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20210930
PL  - United States
TA  - Biol Psychiatry Glob Open Sci
JT  - Biological psychiatry global open science
JID - 9918227369306676
PMC - PMC9616363
OTO - NOTNLM
OT  - Brain volume
OT  - Clinical High Risk
OT  - Meta-analysis
OT  - Neuroimaging
OT  - Schizophrenia
OT  - Structural MRI
EDAT- 2021/09/30 00:00
MHDA- 2021/09/30 00:01
PMCR- 2021/09/30
CRDT- 2022/11/03 02:42
PHST- 2021/05/03 00:00 [received]
PHST- 2021/09/04 00:00 [revised]
PHST- 2021/09/10 00:00 [accepted]
PHST- 2022/11/03 02:42 [entrez]
PHST- 2021/09/30 00:00 [pubmed]
PHST- 2021/09/30 00:01 [medline]
PHST- 2021/09/30 00:00 [pmc-release]
AID - S2667-1743(21)00109-9 [pii]
AID - 10.1016/j.bpsgos.2021.09.002 [doi]
PST - epublish
SO  - Biol Psychiatry Glob Open Sci. 2021 Sep 30;2(2):147-152. doi: 
      10.1016/j.bpsgos.2021.09.002. eCollection 2022 Apr.