PMID- 36329300
OWN - NLM
STAT- MEDLINE
DCOM- 20221107
LR  - 20221228
IS  - 1573-3890 (Electronic)
IS  - 1573-3882 (Print)
IS  - 1573-3882 (Linking)
VI  - 18
IP  - 11
DP  - 2022 Nov 3
TI  - Exposure to persistent organic pollutants alters the serum metabolome in 
      non-obese diabetic mice.
PG  - 87
LID - 10.1007/s11306-022-01945-0 [doi]
LID - 87
AB  - INTRODUCTION: Autoimmune disorders such as type 1 diabetes (T1D) are believed to 
      be caused by the interplay between several genetic and environmental factors. 
      Elucidation of the role of environmental factors in metabolic and immune 
      dysfunction leading to autoimmune disease is not yet well characterized. 
      OBJECTIVES: Here we investigated the impact of exposure to a mixture of 
      persistent organic pollutants (POPs) on the metabolome in non-obese diabetic 
      (NOD) mice, an experimental model of T1D. The mixture contained organochlorides, 
      organobromides, and per- and polyfluoroalkyl substances (PFAS). METHODS: Analysis 
      of molecular lipids (lipidomics) and bile acids in serum samples was performed by 
      UPLC-Q-TOF/MS, while polar metabolites were analyzed by GC-Q-TOF/MS. RESULTS: 
      Experimental exposure to the POP mixture in these mice led to several metabolic 
      changes, which were similar to those previously reported as associated with PFAS 
      exposure, as well as risk of T1D in human studies. This included an increase in 
      the levels of sugar derivatives, triacylglycerols and lithocholic acid, and a 
      decrease in long chain fatty acids and several lipid classes, including 
      phosphatidylcholines, lysophosphatidylcholines and sphingomyelins. CONCLUSION: 
      Taken together, our study demonstrates that exposure to POPs results in an 
      altered metabolic signature previously associated with autoimmunity.
CI  - (c) 2022. The Author(s).
FAU - Sinioja, Tim
AU  - Sinioja T
AD  - School of Science and Technology, Orebro University, 702 81, Orebro, Sweden.
FAU - Bodin, Johanna
AU  - Bodin J
AD  - Division of Infection Control and Environmental Health, Norwegian Institute of 
      Public Health, 0456, Oslo, Norway.
FAU - Duberg, Daniel
AU  - Duberg D
AD  - School of Science and Technology, Orebro University, 702 81, Orebro, Sweden.
FAU - Dirven, Hubert
AU  - Dirven H
AD  - Division of Infection Control and Environmental Health, Norwegian Institute of 
      Public Health, 0456, Oslo, Norway.
FAU - Berntsen, Hanne Friis
AU  - Berntsen HF
AD  - Norwegian University of Life Sciences, 1432, As, Norway.
AD  - National Institute of Occupational Health, 0363, Oslo, Norway.
FAU - Zimmer, Karin
AU  - Zimmer K
AD  - Norwegian University of Life Sciences, 1432, As, Norway.
FAU - Nygaard, Unni C
AU  - Nygaard UC
AD  - Division of Infection Control and Environmental Health, Norwegian Institute of 
      Public Health, 0456, Oslo, Norway.
FAU - Oresic, Matej
AU  - Oresic M
AD  - School of Medical Sciences, Orebro University, 702 81, Orebro, Sweden.
AD  - Turku Bioscience Centre, University of Turku and Abo Akademi University, 20520, 
      Turku, Finland.
FAU - Hyotylainen, Tuulia
AU  - Hyotylainen T
AD  - School of Science and Technology, Orebro University, 702 81, Orebro, Sweden. 
      tuulia.hyotylainen@oru.se.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221103
PL  - United States
TA  - Metabolomics
JT  - Metabolomics : Official journal of the Metabolomic Society
JID - 101274889
RN  - 0 (Persistent Organic Pollutants)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Humans
MH  - Mice
MH  - Animals
MH  - Persistent Organic Pollutants
MH  - Mice, Inbred NOD
MH  - *Diabetes Mellitus, Type 1/chemically induced
MH  - *Fluorocarbons
MH  - *Diabetes Mellitus, Experimental
MH  - Metabolomics
MH  - Metabolome
PMC - PMC9633531
OTO - NOTNLM
OT  - Environmental exposure
OT  - Exposomics
OT  - Metabolomics
OT  - Perfluorinated alkyl substances
OT  - Persistent organic pollutants
OT  - Type 1 diabetes
COIS- The authors declare no competing interests.
EDAT- 2022/11/05 06:00
MHDA- 2022/11/08 06:00
PMCR- 2022/11/03
CRDT- 2022/11/04 00:40
PHST- 2022/03/09 00:00 [received]
PHST- 2022/10/11 00:00 [accepted]
PHST- 2022/11/04 00:40 [entrez]
PHST- 2022/11/05 06:00 [pubmed]
PHST- 2022/11/08 06:00 [medline]
PHST- 2022/11/03 00:00 [pmc-release]
AID - 10.1007/s11306-022-01945-0 [pii]
AID - 1945 [pii]
AID - 10.1007/s11306-022-01945-0 [doi]
PST - epublish
SO  - Metabolomics. 2022 Nov 3;18(11):87. doi: 10.1007/s11306-022-01945-0.