PMID- 36330940
OWN - NLM
STAT- MEDLINE
DCOM- 20221206
LR  - 20221206
IS  - 1879-3363 (Electronic)
IS  - 0025-326X (Linking)
VI  - 185
IP  - Pt A
DP  - 2022 Dec
TI  - Assessing the size-dependent effects of microplastics on zebrafish larvae through 
      fish lateral line system and gut damage.
PG  - 114279
LID - S0025-326X(22)00961-4 [pii]
LID - 10.1016/j.marpolbul.2022.114279 [doi]
AB  - This study evaluated the size-dependent effects of high-density polyethylene 
      (HDPE) fragments in zebrafish. Larvae were exposed to HDPE microplastic (MP) in 
      three sizes, small (14.12 mum), medium (80.32 mum), and large (120.97 mum), at 
      20 mg/L. Size-dependent effects in terms of MP intake, subsequent gut damage, and 
      behavioral changes were observed. The results showed that HDPE exposure did not 
      affect the survivability of zebrafish larvae but caused two significant changes. 
      First, exposure to large MPs caused the most serious damage to hair cells and 
      mechanosensory receptors in the fish's lateral line system. Second, exposure to 
      MPs < 100 mum resulted in their ingestion by larvae, thereby causing morphological 
      changes in the gastrointestinal tract. All larvae exposed to MPs showed 
      behavioral pattern changes associated with size differences. This study improves 
      our understanding of the effects of MPs on aquatic organisms and highlights the 
      need to implement efficient strategies for plastic waste management.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Kim, Sang A
AU  - Kim SA
AD  - Department of Environmental Health Science, Konkuk University, 120 Neungdong-ro, 
      Gwangjin-gu, Seoul 05029, Republic of Korea.
FAU - Kim, Lia
AU  - Kim L
AD  - Department of Environmental Health Science, Konkuk University, 120 Neungdong-ro, 
      Gwangjin-gu, Seoul 05029, Republic of Korea.
FAU - Kim, Tae Hee
AU  - Kim TH
AD  - Advanced Textile R&D Department, Korea Institute of Industrial Technology, Ansan 
      426-171, Republic of Korea.
FAU - An, Youn-Joo
AU  - An YJ
AD  - Department of Environmental Health Science, Konkuk University, 120 Neungdong-ro, 
      Gwangjin-gu, Seoul 05029, Republic of Korea. Electronic address: 
      anyjoo@konkuk.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20221029
PL  - England
TA  - Mar Pollut Bull
JT  - Marine pollution bulletin
JID - 0260231
RN  - 0 (Microplastics)
RN  - 0 (Plastics)
RN  - 9002-88-4 (Polyethylene)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Animals
MH  - Microplastics
MH  - Plastics/toxicity
MH  - Zebrafish
MH  - Larva
MH  - Polyethylene/toxicity
MH  - *Lateral Line System/chemistry
MH  - *Water Pollutants, Chemical/toxicity/analysis
OTO - NOTNLM
OT  - Aquatic toxicity
OT  - HDPE
OT  - High-density polyethylene
OT  - Plastic
OT  - Swimming behavior
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/11/05 06:00
MHDA- 2022/12/07 06:00
CRDT- 2022/11/04 06:10
PHST- 2022/08/17 00:00 [received]
PHST- 2022/10/13 00:00 [revised]
PHST- 2022/10/17 00:00 [accepted]
PHST- 2022/11/05 06:00 [pubmed]
PHST- 2022/12/07 06:00 [medline]
PHST- 2022/11/04 06:10 [entrez]
AID - S0025-326X(22)00961-4 [pii]
AID - 10.1016/j.marpolbul.2022.114279 [doi]
PST - ppublish
SO  - Mar Pollut Bull. 2022 Dec;185(Pt A):114279. doi: 10.1016/j.marpolbul.2022.114279. 
      Epub 2022 Oct 29.